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Keywords: Human
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Journal Articles
Journal: Development
Development (2022) 149 (3): dev200195.
Published: 1 February 2022
... that this is conserved in humans. Overall, we demonstrate that functional vascular patterning in the zebrafish trunk is established through differential cell migration regulated by junctional actin, and that interruption of differential migration may represent a pathomechanism in vascular malformations. Competing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199840.
Published: 12 January 2022
... is known about the processes controlling human CTB progenitor maintenance and differentiation. To address this, we established a single cell RNA sequencing (scRNA-seq) dataset from first trimester placentas to identify cell states important in trophoblast progenitor establishment, renewal...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2022) 149 (8): dev199781.
Published: 26 October 2021
...René Reitermaier; Tanya Ayub; Julia Staller; Philip Kienzl; Nikolaus Fortelny; Pablo Augusto Vieyra-Garcia; Christof Worda; Christian Fiala; Clement Staud; Wolfgang Eppel; Anke Scharrer; Thomas Krausgruber; Adelheid Elbe-Bürger ABSTRACT The adult human skin contains a vast number of T cells...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2021) 148 (20): dev199626.
Published: 19 October 2021
...Matthew Gormley; Oliver Oliverio; Mirhan Kapidzic; Katherine Ona; Steven Hall; Susan J. Fisher ABSTRACT Human placental architecture is complex. Its surface epithelium, specialized for transport, forms by fusion of cytotrophoblast progenitors into multinucleated syncytiotrophoblasts. Near...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2021) 148 (15): dev199711.
Published: 5 August 2021
... neuronal subtypes generated in a characteristic spatiotemporal arrangement from progenitors in the embryonic neural tube. To gain insight into the diversity and complexity of cells in the developing human neural tube, we used single-cell mRNA sequencing to profile cervical and thoracic regions in four...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (15): dev196477.
Published: 3 August 2021
...-coding and repetitive DNA. We therefore analyzed the genome-wide distribution of the heterochromatic marker H4K20me3 in human sperm and somatic (K562) cells. To specify the function of sperm histones, we compared all H4K20me3-containing and -free loci in the sperm genome. Sperm and somatic cells...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (13): dev199561.
Published: 1 July 2021
...Hao Chen; Katherine E. Williams; Elaine Y. Kwan; Mirhan Kapidzic; Kenisha A. Puckett; Rayyan K. Aburajab; Joshua F. Robinson; Susan J. Fisher ABSTRACT During human pregnancy, cytotrophoblasts (CTBs) from the placenta differentiate into specialized subpopulations that play crucial roles in proper...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2021) 148 (6): dev194514.
Published: 29 March 2021
... remains unclear. Here, we studied HOX clock pacing in human pluripotent stem cell-derived axial progenitors differentiating into diverse spinal cord motor neuron subtypes. We show that the progressive activation of caudal HOX genes is controlled by a dynamic increase in FGF signaling. Blocking the FGF...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev191213.
Published: 21 September 2020
... contributions of data on craniofacial and dental development in humans, model organisms and cell lines. Collectively, the FaceBase Consortium, along with other NIH-supported data resources, provide a continuously growing, dynamic and current resource for the scientific community while improving data...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev187013.
Published: 8 September 2020
.../fetus and the mother. We isolated EVs from second trimester human cytotrophoblasts (CTBs) by differential ultracentrifugation and characterized them using transmission electron microscopy, immunoblotting and mass spectrometry. The 100,000 g pellet was enriched for vesicles with a cup-like morphology...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (9): dev184481.
Published: 12 May 2020
... ( Untergasser et al., 2012 ). The final distribution of endogenous CRISPR/Cas9 arrays over the genomes when searching for arrays with more than eight CRISPR/Cas9 target sites per window is shown in Fig. 2 A-C for zebrafish, mouse and human, respectively. As can be seen, potential CRISPR/Cas9 arrays exist...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (2): dev181263.
Published: 23 January 2020
... findings have obscured the role of oxygen in regulating invasive trophoblast differentiation. In this study, the effect of hypoxic, normoxic and atmospheric oxygen on invasive extravillous pathway progression was examined using a human placental explant model. Here, we show that exposure to low oxygen...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (1): dev183095.
Published: 3 January 2020
... regulation and a paradigm for epigenetic processes. Although XCI has been substantially deciphered in the mouse model, how this process is initiated in humans has long remained unexplored. However, recent advances in the experimental capacity to access human embryonic-derived material and in the laws...
Journal Articles
Journal: Development
Development (2019) 146 (24): dev180620.
Published: 16 December 2019
... primitive endoderm (PrE), the blastocyst-stage progenitor of the extra-embryonic endoderm. Here, we apply this context dependency to human ESCs, showing that activation of Nodal and Wnt signalling drives the differentiation of naïve pluripotent cells toward extra-embryonic PrE, or hypoblast, and these can...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev180349.
Published: 1 October 2019
...Rui Diogo; Natalia Siomava; Yorick Gitton ABSTRACT We provide the first detailed ontogenetic analysis of human limb muscles using whole-mount immunostaining. We compare our observations with the few earlier studies that have focused on the development of these muscles, and with data available...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev179564.
Published: 12 September 2019
...Iain Martyn; Eric D. Siggia; Ali H. Brivanlou ABSTRACT Although fate maps of early embryos exist for nearly all model organisms, a fate map of the gastrulating human embryo remains elusive. Here, we use human gastruloids to piece together a rudimentary fate map for the human primitive streak (PS...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev176354.
Published: 9 August 2019
... of elastogenic genes, including members of the Lox, Fbn and Fbln families. Expression of EGF family members increased when Tgfb1 was repressed in mouse. Similar, but not identical, results were found in human BPD lung samples. In vitro , blocking PDGF signaling decreased elastogenic gene expression associated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174615.
Published: 28 June 2019
.... Finally, it is also required for EGFR membrane targeting, recycling and signaling in human cells. Therefore, this study reveals a novel function of the exocyst in niche cells to promote stem cell progeny differentiation by directly controlling EGFR membrane trafficking and signaling in vivo , and also...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev167833.
Published: 9 November 2018
... profiling allow detailed analysis of embryogenesis in other eutherian species, including human, to distinguish conserved from divergent regulatory programs and signalling pathways in the rodent paradigm. Here, we identify and compare transcriptional features of human, marmoset and mouse embryos by single...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2018) 145 (16): dev164038.
Published: 30 August 2018
... to give rise to the entire collecting system and the nephrons. Most of our knowledge of the developmental regulators driving this process arises from the study of gene expression and functional genetics in mice and other animal models. In order to shed light on human kidney development, we have used...
Includes: Supplementary data