1-20 of 77
Keywords: Human
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
In collection:
Human development
Journal: Development
Development (2021) 148 (6): dev194514.
Published: 29 March 2021
... extrinsic cues remains unclear. Here, we studied HOX clock pacing in human pluripotent stem cell-derived axial progenitors differentiating into diverse spinal cord motor neuron subtypes. We show that the progressive activation of caudal HOX genes is controlled by a dynamic increase in FGF signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev191213.
Published: 21 September 2020
... contributions of data on craniofacial and dental development in humans, model organisms and cell lines. Collectively, the FaceBase Consortium, along with other NIH-supported data resources, provide a continuously growing, dynamic and current resource for the scientific community while improving data...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev187013.
Published: 08 September 2020
.../fetus and the mother. We isolated EVs from second trimester human cytotrophoblasts (CTBs) by differential ultracentrifugation and characterized them using transmission electron microscopy, immunoblotting and mass spectrometry. The 100,000 g pellet was enriched for vesicles with a cup-like morphology...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (9): dev184481.
Published: 12 May 2020
... feasible in non-model species for which it is hard to generate transgenic animals. CRISPR Human Lineage Tracing Mouse Zebrafish Handling Editor: James Briscoe Competing interests The authors declare no competing or financial interests. Finally, we attempted to use our M7...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (2): dev181263.
Published: 23 January 2020
... findings have obscured the role of oxygen in regulating invasive trophoblast differentiation. In this study, the effect of hypoxic, normoxic and atmospheric oxygen on invasive extravillous pathway progression was examined using a human placental explant model. Here, we show that exposure to low oxygen...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (1): dev183095.
Published: 03 January 2020
... regulation and a paradigm for epigenetic processes. Although XCI has been substantially deciphered in the mouse model, how this process is initiated in humans has long remained unexplored. However, recent advances in the experimental capacity to access human embryonic-derived material and in the laws...
Journal Articles
Journal: Development
Development (2019) 146 (24): dev180620.
Published: 16 December 2019
... primitive endoderm (PrE), the blastocyst-stage progenitor of the extra-embryonic endoderm. Here, we apply this context dependency to human ESCs, showing that activation of Nodal and Wnt signalling drives the differentiation of naïve pluripotent cells toward extra-embryonic PrE, or hypoblast, and these can...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev180349.
Published: 01 October 2019
...Rui Diogo; Natalia Siomava; Yorick Gitton ABSTRACT We provide the first detailed ontogenetic analysis of human limb muscles using whole-mount immunostaining. We compare our observations with the few earlier studies that have focused on the development of these muscles, and with data available on...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev179564.
Published: 12 September 2019
...Iain Martyn; Eric D. Siggia; Ali H. Brivanlou ABSTRACT Although fate maps of early embryos exist for nearly all model organisms, a fate map of the gastrulating human embryo remains elusive. Here, we use human gastruloids to piece together a rudimentary fate map for the human primitive streak (PS...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev176354.
Published: 09 August 2019
... elastogenic genes, including members of the Lox, Fbn and Fbln families. Expression of EGF family members increased when Tgfb1 was repressed in mouse. Similar, but not identical, results were found in human BPD lung samples. In vitro , blocking PDGF signaling decreased elastogenic gene expression associated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174615.
Published: 28 June 2019
.... Finally, it is also required for EGFR membrane targeting, recycling and signaling in human cells. Therefore, this study reveals a novel function of the exocyst in niche cells to promote stem cell progeny differentiation by directly controlling EGFR membrane trafficking and signaling in vivo , and also...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev167833.
Published: 09 November 2018
... profiling allow detailed analysis of embryogenesis in other eutherian species, including human, to distinguish conserved from divergent regulatory programs and signalling pathways in the rodent paradigm. Here, we identify and compare transcriptional features of human, marmoset and mouse embryos by single...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2018) 145 (16): dev164038.
Published: 30 August 2018
... to give rise to the entire collecting system and the nephrons. Most of our knowledge of the developmental regulators driving this process arises from the study of gene expression and functional genetics in mice and other animal models. In order to shed light on human kidney development, we have used...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2018) 145 (16): dev165480.
Published: 15 August 2018
... cells present in the human fetal pancreas and their lineage relationships, we developed strategies to isolate pancreatic progenitors, endocrine progenitors and endocrine cells. Transcriptome analysis of the individual populations revealed a large degree of conservation among vertebrates in the drivers...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2018) 145 (16): dev165597.
Published: 13 August 2018
... humans, and their impact on Notch1 activation during T-lymphopoiesis remains undefined. Based on immunohistochemistry and quantitative confocal microscopy of fetal, postnatal and adult human and mouse thymus samples, we show that spatial regulation of Notch ligand expression defines discrete Notch...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (3): dev158501.
Published: 07 February 2018
...Giuliano G. Stirparo; Thorsten Boroviak; Ge Guo; Jennifer Nichols; Austin Smith; Paul Bertone ABSTRACT Single-cell profiling techniques create opportunities to delineate cell fate progression in mammalian development. Recent studies have provided transcriptome data from human pre-implantation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4588–4603.
Published: 15 December 2017
... Nrf2 regulation. Consistent with this, we revealed that Nrf2 associates with the actin cytoskeleton in cells and binds to filamentous actin in vitro . Finally, we discovered that Arpc4 is downregulated in both human and mouse psoriatic epidermis. Thus, the Arp2/3 complex affects keratinocyte shape and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3698–3705.
Published: 15 October 2017
... presenting new therapeutic promise for retinal degenerative diseases. From a translational perspective, organoid systems provide exciting new prospects for drug discovery, offering the possibility to perform compound screening in a three-dimensional (3D) human tissue context that resembles the native...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3744–3754.
Published: 15 October 2017
.... Islet Chemoattractant Radial migration Nrp2 Sema3a Neural development Cortex Mouse Human Pancreatic β cell distribution was strongly shifted toward beads soaked in Sema3a ( P= 0.01 relative to PBS control beads, Fig. 1 B,C,E,F). We also observed clustering of glucagon + α cells adjacent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3659–3673.
Published: 15 October 2017
... chromatin condensation. Although studied in mice, the molecular control of human spermatogenesis is largely unknown. Here, we developed a protocol that enables next-generation sequencing of RNA obtained from pools of 500 individually laser-capture microdissected cells of specific germ cell subtypes from...
Includes: Supplementary data