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Keywords: Human
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Journal Articles
Journal: Development
Development (2024) 151 (4): dev199797.
Published: 16 February 2024
... stem cell type, the basal (or outer) radial glia. Next, we concentrate on primate-specific and human-specific genes, expressed in OSVZ-progenitors, the ability of which to amplify these progenitors by targeting the regulation of the cell cycle ultimately underlies the evolutionary increase in upper...
Journal Articles
In collection:
Human development
Journal: Development
Development (2024) 151 (3): dev202098.
Published: 12 February 2024
... induction of NMPs from human embryonic stem cells (hESCs) relies on Notch signalling. Using hESC-derived NMPs and chick embryo grafting, we demonstrate that Notch directs a pro-mesodermal character at the expense of neural fate. We show that Notch also contributes to activation of HOX gene expression...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (16): dev201896.
Published: 22 August 2023
... is common across evolution. Functions of such polyploidy are essentially unknown. Here, in both Drosophila larvae and human organ donors, we reveal distinct polyploidy levels in cardiac organ chambers. In Drosophila , differential growth and cell cycle signal sensitivity leads the heart chamber to reach...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (14): dev201515.
Published: 18 July 2023
... of the mitotic spindle in vitro in human cells and in vivo in Xenopus . Investigation of CHD2 provides evidence that mutations present in individuals with ASD cause a range of microtubule-related phenotypes, including disrupted localization of the protein at mitotic spindles, cell cycle stalling, DNA damage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (14): dev201509.
Published: 13 July 2023
...Olga G. Jaime; Jessica Arias; Shreya Pavani; April D. Pyle; Michael R. Hicks ABSTRACT The earliest skeletal muscle progenitor cells (SMPCs) derived from human pluripotent stem cells (hPSCs) are often identified by factors expressed by a diverse number of progenitors. An early transcriptional...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Human development
Journal: Development
Development (2023) 150 (12): dev201071.
Published: 29 June 2023
... underlying the diversification of these cell lineages remain unclear. To determine the transcriptional trajectory of prosensory cells, we established a SOX2 -2A-ntdTomato human embryonic stem cell line using CRISPR/Cas9, and performed single-cell RNA-sequencing analyses with SOX2 -positive cells isolated...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (10): dev201430.
Published: 24 May 2023
.... To investigate this, we analyzed the expression profile of spermatogonial markers during the seminiferous epithelial cycle in cynomolgus monkeys and compared the results with human data. We found that in cynomolgus monkeys, as in humans, undifferentiated spermatogonia are largely quiescent, and the few engaged...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (4): dev201313.
Published: 13 February 2023
... formation, productivity and function in the context of reproductive success in mammalian systems, primarily mouse and human. Although much is known about the specific genes and proteins required for meiotic processes and sperm function, we know relatively little about other gametic determinants of overall...
Journal Articles
Journal: Development
Development (2023) 150 (2): dev200399.
Published: 30 January 2023
... in this morphogenetic process. In this Review, we summarize the resulting scenarios and proposed models that include common and species-specific events. We further discuss how these studies and those in environmentally adapted blind species may shed light on human inborn eye malformations that result from failures...
Journal Articles
Journal: Development
Development (2022) 149 (19): dev200717.
Published: 4 October 2022
... endothelial-fibronectin interactions in FGR are a key mechanism underlying impaired FGR endothelial migration. Using human fetoplacental endothelial cells isolated from uncomplicated term control and FGR pregnancies, we assessed integrin α5β1 and αvβ3 regulation during cell migration. We show that endothelial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (16): dev200765.
Published: 18 August 2022
... by The Company of Biologists Ltd 2022 Summary: This Review presents the intrinsic and extrinsic mechanical forces acting on the embryonic gut and their determining role in structuring the development of this organ. Biomechanics Intestine Embryo Mouse Chicken Human Université de Paris...
Journal Articles
In collection:
Human development
Journal: Development
Development (2022) 149 (13): dev200432.
Published: 29 June 2022
...Xiaodun Yang; Jeffrey C. Raum; Junil Kim; Reynold Yu; Juxiang Yang; Gabriella Rice; Changhong Li; Kyoung-Jae Won; Diana E. Stanescu; Doris A. Stoffers ABSTRACT Pancreatic and duodenal homeobox 1 (PDX1) is crucial for pancreas organogenesis, yet the dynamic changes in PDX1 binding in human or mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (20): dev199723.
Published: 24 June 2022
... therapies for leukodystrophies. However, caveats to oligodendrocyte differentiation protocols ( Ehrlich et al., 2017 ; Wang et al., 2013 ; Douvaras and Fossati, 2015 ) from human embryonic stem and induced pluripotent stem cells (iPSCs), which include slow and inefficient differentiation, and tumorigenic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (3): dev200195.
Published: 1 February 2022
... that this is conserved in humans. Overall, we demonstrate that functional vascular patterning in the zebrafish trunk is established through differential cell migration regulated by junctional actin, and that interruption of differential migration may represent a pathomechanism in vascular malformations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199840.
Published: 12 January 2022
... is known about the processes controlling human CTB progenitor maintenance and differentiation. To address this, we established a single cell RNA sequencing (scRNA-seq) dataset from first trimester placentas to identify cell states important in trophoblast progenitor establishment, renewal...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2022) 149 (8): dev199781.
Published: 26 October 2021
...René Reitermaier; Tanya Ayub; Julia Staller; Philip Kienzl; Nikolaus Fortelny; Pablo Augusto Vieyra-Garcia; Christof Worda; Christian Fiala; Clement Staud; Wolfgang Eppel; Anke Scharrer; Thomas Krausgruber; Adelheid Elbe-Bürger ABSTRACT The adult human skin contains a vast number of T cells...
Includes: Supplementary data