... expression coincide with distinct anatomical vertebrae. However, because functional analyses have been limited to mice, it remains unclear which Hox genes actually function in vertebral patterning in other vertebrates. In this study, various zebrafish Hox mutants were generated for loss-of-function...

... segments. This homeotic transformation is caused by loss of abdominal Hox gene expression, likely due to expanded Tc-Krüppel expression. Our findings support the theory that the neuroblast timer series was co-opted for use in insect segment patterning, and contribute to our growing understanding...

... Hox gene Japan Society for the Promotion of Science 10.13039/501100001691 25251041 14J02703 17J06879 Ministry of Education, Culture, Sports, Science and Technology 10.13039/501100001700 National Institute for Basic Biology 10.13039/501100006324...

...Simon G. Sprecher; Rolf Urbach; Gerhard M. Technau; Filippo M. Rijli; Heinrich Reichert; Frank Hirth In Drosophila , evolutionarily conserved transcription factors are required for the specification of neural lineages along the anteroposterior and dorsoventral axes, such as Hox genes...

... has led to a model in which each regulatory region is important in specifying homeotic gene expression in one parasegment. For example, iab-5 is thought to control the expression of Abd-B in PS10/A5, while iab-6 is thought to control expression of Abd-B in PS11/A6. Bithorax Hox gene...

.... Whereas previous syntheses have tended to focus on the roles of genes from a single gene family, most notably Hox genes, we emphasize the importance of considering the interactions among multiple genes from different gene families for understanding the evolution of complex developmental systems. Our...

... crest Hox gene Pax gene Fgf Embryo culture Mouse Pharyngeal arches (PA) are transient bulges of the embryonic surface that develop in a cranial to caudal sequence between the head and the heart and are separated by evaginations of the pharyngeal endoderm, the pharyngeal pouches. Adult...

... with a temperature-sensitive type II receptor mutant, as well as heat-shock induction experiments, show that the DBL-1 pathway acts during an interval that extends from two to one cell generation before ray neurons are born and begin to differentiate. In a mutant of the AbdominalB class Hox gene egl-5 , rays...

...Stefan Jungbluth; Esther Bell; Andrew Lumsden ABSTRACT Hox genes have been implicated in specifying positional values along the anteroposterior axis of the caudal central nervous system, but their nested and overlapping expression has complicated the understanding of how they confer specific neural...

...Karin Brunschwig; Claudia Wittmann; Ralf Schnabel; Thomas R. Bürglin; Heinz Tobler; Fritz Müller The Caenorhabditis elegans lin-39, mab-5 and egl-5 Hox genes specify cell fates along the anterior-posterior body axis of the nematode during postembryonic development, but little is known about Hox...

...Craig P. Hunter; Jeanne M. Harris; Julin N. Maloof; Cynthia Kenyon In Caenorhabditis elegans males, a row of epidermal precursor cells called seam cells generates a pattern of cuticular alae in anterior body regions and neural sensilla called rays in the posterior. The Hox gene mab-5 is required...

...Miguel Manzanares,; Sabine Cordes,; Linda Ariza-McNaughton,; Virginia Sadl,; Kamala Maruthainar,; Greg Barsh; Robb Krumlauf During anteroposterior patterning of the developing hindbrain, the anterior expression of 3′ Hox genes maps to distinct rhombomeric boundaries and, in many cases...

...Julin N. Maloof; Jennifer Whangbo; Jeanne M. Harris; Gregg D. Jongeward; Cynthia Kenyon ABSTRACT The specification of body pattern along the anteroposterior (A/P) body axis is achieved largely by the actions of conserved clusters of Hox genes. Limiting expression of these genes to localized...

...Alastair Morrison; Linda Ariza-McNaughton; Alex Gould; Mark Featherstone; Robb Krumlauf ABSTRACT From an evolutionary perspective, it is important to understand the degree of conservation of cis -regulatory mechanisms between paralogous Hox genes. In this study, we have used transgenic analysis...

...Jeanne Harris; Lee Honigberg; Naomi Robinson; Cynthia Kenyon ABSTRACT In C. elegans , the Hox gene mab-5 , which specifies the fates of cells in the posterior body region, has been shown to direct the migrations of certain cells within its domain of function. mab-5 expression switches...

... by Company of Biologists 1996 quail-chick chimaera fate map hox gene rhombomere hindbrain The hindbrain undergoes a fundamental change in its organisation during development. The early embryonic hindbrain (at E2-E5) is characterised by transient segmental swellings ( Vaage, 1969...

...Stephen J. Salser; Cynthia Kenyon ABSTRACT Hox genes establish body pattern throughout the animal kingdom, but the role these genes play at the cellular level to modify and shape parts of the body remains a mystery. We find that the C. elegans Antennapedia homolog, mab-5 , sequentially programs...

... is maintained in both migrating neural crest cells and those positioned within the second branchial arch and associated ganglia. These results suggest that Hoxa3 expression is cellautonomous in r6 and its associated neural crest. Our results suggest that neural crest cells expressing the same Hox gene...

.... Here, we investigated expression of the ascidian labial group Hox gene HrHox-1 in the development of Halo-cynthia roretzi. HrHox-1 showed a spatially restricted expression pattern along the anterior-posterior axis, which is remarkably similar to that of the vertebrate gene, Hoxb-1 . The expression...

... genes may be different in these early and late roles. The combined action of many Hox genes on distinct developmental processes contribute to pattern asymmetry along the A-P axis. © 1994 by Company of Biologists 1994 Hox gene limb bud morphogenesis axis specification anteroposterior...