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Keywords: Hox
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Journal Articles
Journal: Development
Development (2020) 147 (22): dev194761.
Published: 23 November 2020
...Milica Bulajić; Divyanshi Srivastava; Jeremy S. Dasen; Hynek Wichterle; Shaun Mahony; Esteban O. Mazzoni ABSTRACT Although Hox genes encode for conserved transcription factors (TFs), they are further divided into anterior, central and posterior groups based on their DNA-binding domain similarity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev167882.
Published: 26 July 2019
... Article: The development of protrusions, such as eminences and condyles, along long bones in mice is coordinated by a patterning mechanism involving global and regional genetic regulation. Cartilage Patterning Morphology Superstructure Sox9 Scleraxis Modularity Gli3 Pbx Hox Mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (1): dev168161.
Published: 02 January 2019
... progenitors; NMPs, LPMPs and NotoPs). Both NMP and LPMP transcriptomes change extensively over time. In particular, NMPs upregulate Wnt, Fgf and Notch signalling components, and many Hox genes as progenitors transit from production of the trunk to the tail and expand in number. In contrast, the transcriptome...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev161133.
Published: 16 October 2018
...Richard Kaschula; Sofia Pinho; Claudio R. Alonso ABSTRACT Disruptions of normal Hox gene expression can lead to severe morphological defects, revealing a link between the regulation of Hox expression and pattern formation. Here, we explore these links, focusing on the impact of microRNA regulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4645–4657.
Published: 15 December 2017
..., but revealed the role of Foxp1 in conferring LMC identity on the cervical MNs. Furthermore, ectopic expression of Hox genes that are normally expressed in the brachial region prevented apoptosis, and directed Foxp1 + MNs to LMC neurons at the cervical level. These results indicate that apoptosis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (9): 1629–1634.
Published: 01 May 2017
...Keita Yoshida; Azusa Nakahata; Nicholas Treen; Tetsushi Sakuma; Takashi Yamamoto; Yasunori Sasakura The chordate pharynx, possessing gill slits and the endostyle, is a complex of multiple tissues that are highly organized along the anterior-posterior (AP) axis. Although Hox genes show AP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (7): 1212–1227.
Published: 01 April 2015
...René Rezsohazy; Andrew J. Saurin; Corinne Maurel-Zaffran; Yacine Graba Hox genes encode homeodomain transcription factors that control morphogenesis and have established functions in development and evolution. Hox proteins have remained enigmatic with regard to the molecular mechanisms that endow...
Journal Articles
Journal: Development
Development (2015) 142 (1): 185–195.
Published: 01 January 2015
... identified several input pathways: Hox paralogous 1 (PG1) factors, which both directly activate krox20 and indirectly repress it via Nlz factors, and the molecular components of an Fgf-dependent effector pathway. These different inputs are channelled through a single initiator enhancer element to shape...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (10): 2046–2056.
Published: 15 May 2014
...Ana Rogulja-Ortmann; Joao Picao-Osorio; Casandra Villava; Pedro Patraquim; Elvira Lafuente; Julie Aspden; Stefan Thomsen; Gerhard M. Technau; Claudio R. Alonso The regulated head-to-tail expression of Hox genes provides a coordinate system for the activation of specific programmes of cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (7): 1492–1502.
Published: 01 April 2014
...Fabrice Prin; Patricia Serpente; Nobue Itasaki; Alex P. Gould Hox genes encode a conserved family of homeodomain transcription factors regulating development along the major body axis. During embryogenesis, Hox proteins are expressed in segment-specific patterns and control numerous different...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (7): 1534–1543.
Published: 01 April 2014
... no competing financial interests. 5 12 2013 2 2 2014 © 2014. Published by The Company of Biologists Ltd 2014 Vertebrate limb Patterning Proximo-distal Meis Hox Epigenetics Retinoic acid FGF Chick Mouse Development of the main axis of vertebrate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (21): 4386–4397.
Published: 01 November 2013
... ) Competing interests statement The authors declare no competing financial interests. 19 8 2013 © 2013. Published by The Company of Biologists Ltd 2013 Hox BMP Craniofacial development External auditory canal Neural crest Pharyngeal arch Pinna Auricle External...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (17): 3180–3188.
Published: 01 September 2012
... that different combinations of Hox proteins expressed in different rostral and caudal domains of the lateral plate mesoderm, where limb induction occurs, might be involved in regulating the limb type-restricted expression of Tbx4 and Tbx5 and in the later determination of limb type-specific morphologies. Here...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (21): 4649–4660.
Published: 01 November 2011
...Mark W. Pellegrino; Sarfarazhussain Farooqui; Erika Fröhli; Hubert Rehrauer; Stéphanie Kaeser-Pebernard; Fritz Müller; Robin B. Gasser; Alex Hajnal Morphogenesis represents a phase of development during which cell fates are executed. The conserved hox genes are key cell fate determinants during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (17): 3759–3767.
Published: 01 September 2011
... and proximodistal segment elongation. Ezh2 maintains the late phase of Hox gene expression and cell transposition experiments suggest that it regulates the plasticity with which cells respond to instructive positional cues. * Author for correspondence ( sevan.hopyan@sickkids.ca ) Mouse embryos were...
Journal Articles
Journal: Development
Development (2011) 138 (6): 1033–1043.
Published: 15 March 2011
... fate, over a differentiated striated bodywall muscle fate. A number of factors control the specific expression of sem-2 in the sex myoblast precursors and their descendants. This includes direct control of sem-2 expression by a Hox-PBC complex. The crucial nature of the HOX/PBC factors in directly...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (1): 107–116.
Published: 01 January 2011
... Hox gene Ultrabithorax ( Ubx ). Ubx produces a family of six protein isoforms through alternative splicing. To investigate the functional specificity of the Ubx isoforms, we studied their role during the formation of the Drosophila halteres, small dorsal appendages that are essential for normal flight...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (17): 2951–2960.
Published: 01 September 2010
...Stefan Thomsen; Ghows Azzam; Richard Kaschula; Lucy S. Williams; Claudio R. Alonso The Drosophila Hox gene Ultrabithorax ( Ubx ) controls the development of thoracic and abdominal segments, allocating segment-specific features to different cell lineages. Recent studies have shown that Ubx...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (15): 2559–2569.
Published: 01 August 2010
... of Hox gene spatial distribution and Shh expression . Development 133 , 2263 - 2273 . Capellini T. D. , Zewdu R. , Di Giacomo G. , Asciutti S. , Kugler J. E. , Di Gregorio A. , Selleri L. ( 2008 ). Pbx1/Pbx2 govern axial skeletal development by controlling...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (9): 1505–1513.
Published: 01 May 2010
...Tetsuro Ikuta; Nori Satoh; Hidetoshi Saiga In animals, region specific morphological characters along the anteroposterior axis are controlled by a number of developmental genes, including Hox genes encoding homeodomain transcription factors. Although Hox genes have been regarded to play a key role...
Includes: Supplementary data