..., Yorkie forms complexes with several tissue-specific DNA-binding partners, which help to define the tissue-specific target genes of Yorkie. In the progenitor cells of the eye imaginal disc, the DNA-binding transcription factor Homothorax is required for Yorkie-promoted proliferation and survival through...

... on Hedgehog (Hh) signaling, which is delivered by the incoming photoreceptor axons, and occurs in a wave-like fashion. Despite the primary role of lamina neurons in visual perception, it is still unclear how these neurons are specified from neuroepithelial (NE) progenitors. Here we show that a homothorax...

... acts independently of the transcription factor Homothorax, which was previously shown to promote head cuticle development in the same region. Chip and its vertebrate CLIM homologues have been shown to form complexes with LIM-homeodomain transcription factors, and the domain of Chip that mediates...

... Eye disc Eye determination Teashirt Wingless Decapentaplegic Eyes absent Homothorax Atonal During development, groups of cells become singled out as organ primordia through the combined action of organ-specific selector genes and a limited number of signaling pathways (reviewed by Mann...

... and level of these signals and other factors present at the time of signal transduction. Two such factors, teashirt ( tsh ) and homothorax ( hth ), are initially co-expressed throughout the entire wing disc, but are later repressed in distal cells, permitting the subsequent elaboration of distal fates...

..., Spain 28 10 2003 © 2004. 2004 Homothorax Distal-less Nubbin Limb development Imaginal disc The progenitors of the adult body regions in Drosophila are set aside in the embryonic ectoderm as discrete groups of cells known as imaginal discs. The disc primordia contain...

... to differentiation of antenna-specific characteristics. Antenna-specific expression of dan and danr depends on a regulatory hierarchy involving homothorax and Distal-less , as well as cut and spineless . We propose that dan and danr are effector genes that act downstream of these genes to control differentiation...

... and distal cells. Distal-less Dlx extradenticle homothorax Meis Msx Pbx Antenna Audition Brain Branchial arch Dentition Ear Hematopoiesis Interneuron Leg Limb Neural crest Neural tube Olfaction Placode Telencephalon Tooth Tricho-dento-osseous syndrome (TDO...

... territory and by repression of the homeodomain protein Homothorax. We report that repression of the zinc-finger transcription factor Teashirt (Tsh) is the earliest event in wing specification. Repression of Tsh by the combined action of Wingless and Decapentaplegic is required for wing pouch formation...

... for antenna development. The nuclear factors, Homothorax, Distal-less and Spineless, are each required for particular aspects of antennal fate. Coexpression of Homothorax, necessary for nuclear localization of its ubiquitously expressed partner Extradenticle, with Distal-less is required to establish antenna...

...-specifying gene, homothorax , in conjunction with dachshund and spalt , and there is much less overlap between the bric a brac and the dachshund domains. Thus tissue-specific expression of other patterning genes that differentially repress bric a brac accounts for antenna-leg differences in bric a brac...

... arise. I further demonstrate that the proximal-distal patterning genes homothorax and dachshund are positively required, while Distal-less is unexpectedly negatively required, to establish the segmental pattern of Notch ligand and fringe expression. Two Serrate enhancers that respond to regulation...

...Adi Inbal; Naomi Halachmi; Charna Dibner; Dale Frank; Adi Salzberg Homothorax (HTH) is a homeobox-containing protein, which plays multiple roles in the development of the embryo and the adult fly. HTH binds to the homeotic cofactor Extradenticle (EXD) and translocates it to the nucleus. Its...

..., R. (1935) Book Principles of Insect Morphology . New York: McGraw-Hill). To gain insight into how variations between the antenna and the leg may have arisen, we have compared the epistatic relationships among three major proximodistal patterning genes, Distal-less , dachshund and homothorax...

...Natalia Azpiazu; Ginés Morata ABSTRACT The gene homothorax (hth) is originally expressed uniformly in the wing imaginai disc but, during development, its activity is restricted to the cells that form the thorax and the hinge, where the wing blade attaches to the thorax, and eliminated in the wing...

... target genes are activated by wg to generate hinge structures. Here we show that wg activates the gene homothorax ( hth ) in the hinge and that hth is necessary for hinge development. Further, we demonstrate that hth also limits where along the D/V compartment boundary wing blade development can initiate...

...-specifying activity of Distal-less is genetically separable from the proximodistal patterning function in that certain Distal-less allelic combinations exhibit antenna-to-leg transformations without proximodistal truncations. Here, we show that Distal-less acts in parallel with homothorax , a previously...

... localization requires a third homeodomain protein, Homothorax (HTH). Here we show that a conserved N-terminal domain of HTH directly binds to EXD in vitro, and is sufficient to induce the nuclear localization of EXD in vivo. However, mutating a key DNA binding residue in the HTH homeodomain abolishes many...

...Satoshi Goto; Shigeo Hayashi Proximodistal patterning in the Drosophila leg is elaborated from the circular arrangement of the proximal domain expressing escargot and homothorax , and the distal domain expressing Distal-less that are allocated during embryogenesis. The distal domain differentiates...

...Jun Wu; Stephen M. Cohen The developing legs of Drosophila are subdivided into proximal and distal domains by the activity of the homeodomain proteins Homothorax (Hth) and Distal-less (Dll). The expression domains of Dll and Hth are initially reciprocal. Wingless and Dpp define both domains...