..., we describe the use of a novel recombineering strategy to introduce simultaneous frameshift mutations into the flanking Hoxa9, Hoxa10 and Hoxa11 genes, as well as their paralogs on the HoxD cluster. The resulting Hoxa9,10,11 mutant mice displayed dramatic synergistic homeotic transformations...

... downregulation of WNT3A and FGF8 signaling pathways by eliminating ectopic RA in gastrulating tail bud mesoderm. * Author for correspondence (e-mail: [email protected] ) 16 12 2002 © 2003. 2003 Gastrulation Tail bud Cytochrome P450 Homeotic transformations Mouse mutant...

... atavisms mouse homeotic transformations eye skull limb It has long been known that retinol (vitamin A) is crucial for normal growth, vision, reproduction, maintenance of numerous tissues and overall survival ( Wolbach and Howe, 1925 ; see Sporn et al., 1994 and Blomhoff, 1994 , for reviews...

... of the bithorax complex of Drosophila. abdomi - nal-A mutant embryos display strong homeotic transformations of the anterior abdomen (parasegments 7-9) to PS6, whereas developmental commitments in the posterior abdomen depend primarily on Abdominal-B . In beetle embryos lacking Abdominal function, paraseg-ments...