... activity remains unknown. Here, we study the role of Meis in axial skeleton formation and its relationship to the RA pathway in mice. Meis elimination in the paraxial mesoderm produces anterior homeotic transformations and rib mis-patterning associated to alterations of the hypaxial myotome. Although...

... for correspondence( stephen.gaunt@bbsrc.ac.uk ) 6 6 2008 © 2008. 2008 Cdx Overexpression Homeotic transformation Hox Mouse Organization of the developing head-tail axis of the mouse embryo is mediated, at least in part, by the expression patterns of the 39 Hox genes. Each Hox gene...

... Cranial neural crest Pharyngeal arch Anterior-posterior patterning Homeotic transformation Zebrafish Anterior-posterior patterning of the vertebrate head, including segmental identity determination of the seven pharyngeal arches, is governed by differential Hox gene expression (reviewed...

... motif for homeotic transformations in adult Drosophila . By ectopic overexpression, the head structures of the fly can be transformed into structures of the second thoracic segment, such as antenna into second leg, head capsule into thorax (notum) and eye into wing. We found that the YPWM motif...

... cofactors for Distal-less. * Author for correspondence (e-mail: gepangan@facstaff.wisc.edu ) 05 11 1999 © 2000 by Company of Biologists 2000 Distal-less homothorax Antennapedia spalt Antenna Leg Limb Homeotic transformation The similar developmental potentials...

...Allan Peter Davis; Mario R. Capecchi ABSTRACT Using gene targeting, we have created mice with a disruption in the homeobox-containing gene hoxd-11 . Homozygous mutants are viable and the only outwardly apparent abnormality is male infertility. Skeletons of mutant mice show a homeotic transformation...

.... The dens and the superior facets are deleted, and the axis shows ‘atlas-like’ characteristics. An unexpected observation is that different parts of the same vertebra are differentially affected by the loss of Hoxd-3 function. Some parts are deleted, others are homeotically transformed to more anterior...

... ab ) is not part of the zinc-finger domain in the TTK and BR-C proteins, and its function is unknown. 12 08 1993 © 1993 by Company of Biologists 1993 Drosophila bric à brac limb development imaginal discs homeotic transformation BTB domain Drosophila melanogaster...

...Deborah J. Andrew ABSTRACT In specific genetic backgrounds, a mutation in the tuh-3 gene results in the homeotic transformation of head structures to either leg disc derivatives or structures normally found in the extreme posterior end of wild-type animals. The origins of the homeotic structures...

... within the BX-C of a DNA fragment of 17 kb containing pbx + inserted into the Ubx area. In addition to the dominant phenotype, the Cbx 1 mutation produces a set of recessive homeotic transformations that we show are characteristic of the Ubx mutations. We present evidence that the dominant...