... by cooperative interactions with extradenticle, another homeoprotein. Cell 78 , 603 -615. de Zulueta, P., Alexandre, E., Jacq, B. and Kerridge, S. ( 1994 ). Homeotic complex and teashirt genes co-operate to establish trunk segmental identities in Drosophila. Development 120 , 2287 -2296. DiNardo, S...

...Isabelle Manfroid; Xavier Caubit; Stephen Kerridge; Laurent Fasano Drosophila teashirt ( tsh ) functions as a region-specific homeotic gene that specifies trunk identity during embryogenesis. Based on sequence homology, three tsh -like (Tsh) genes have been identified in the mouse. Their expression...

...Man-Wook Hur; Jeffrey D. Laney; Sang-Hack Jeon; Janann Ali; Mark D. Biggin During late embryogenesis, the expression domains of homeotic genes are maintained by two groups of ubiquitously expressed regulators: the Polycomb repressors and the Trithorax activators. It is not known how the activities...

... in wild-type mouthparts and their role if any in this appendage is not well understood. Here we demonstrate that the homeotic gene products Proboscipedia (Pb) and Sex combs reduced (Scr) regulate the limb genes in the labial disc to give rise to a unique type of appendage, the proboscis. Pb inhibits exd...

.... * Author for correspondence (e-mail: [email protected] ) 22 08 200 28 06 2000 © 2000 by Company of Biologists 2000 Drosophila Cnc Maf Deformed Hox Homeotic Pharynx Target genes that are directly activated by CncB/Maf-S are still unknown...

...-mail: [email protected] ) 05 10 1999 © 1999 by Company of Biologists 1999 Hox specificity Homeotic Exd Deformed Labial Drosophila Hox transcription factors play instructive roles in generating morphological diversity along the anteroposterior body axis during animal...

... vesicles, the pharyngeal endoderm and the first branchial arch. Also, oto embryos have dose-dependent, posterior homeotic transformations throughout the axial skeleton. To further dissect the role of the oto locus in head development, we crossed mice carrying oto and Lim1 mutations. Interactions between...

..., suggesting that the Hox- Serrate pathway to segment-specific morphogenesis can be linked to more than one downstream function. * Author for correspondence (e-mail: [email protected] ) 6 April 1999 19 February 1999 © 1999 by Company of Biologists 1999 Serrate Homeotic Hox...

...Gary Daubresse; Renate Deuring; Lisa Moore; Ophelia Papoulas; Irena Zakrajsek; W. Ross Waldrip; Matthew P. Scott; James A. Kennison; John W. Tamkun ABSTRACT The Drosophila kismet gene was identified in a screen for dominant suppressors of Polycomb , a repressor of homeotic genes. Here we show...

... isoforms, CncB is expressed in a localized pattern in mandibular and labral cells of the head during mid-stages of embryogenesis. When CncB protein is absent or reduced, mandibular cells are homeotically transformed toward maxillary identities. This transformation is associated with persistent Deformed...

...Douglas Bornemann; Ellen Miller; Jeffrey Simon ABSTRACT The Sex comb on midleg (Scm) gene is a member of the Polycomb group (PcG) of genes in Drosophila melanogaster . The PcG genes encode transcriptional repressors required for proper spatial expression of homeotic genes. We report the isolation...

... a screen for mutations that alter embryonic patterning of the beetle, Tribolium castaneum . One of the mutations isolated, godzilla , affects early steps in the segmentation process in the whole animal, like Drosophila pair-rule mutants. Another mutation, jaws , is novel: it causes both a dramatic homeotic...

... of expression and homeotic gene regulation is reproduced by an unusual 2.7 kb cis -regulatory sequence located downstream of the unp transcription unit. Since the unp protein is localized to the nucleus of tracheal precursor cells as they migrate and extend, unp protein appears to play a regulatory role...

...Alison McCormick; Nathalie Coré; Stephen Kerridge; Matthew P. Scott ABSTRACT Along the anterior-posterior axis of animal embryos, the choice of cell fates, and the organization of morphogenesis, is regulated by transcription factors encoded by clustered homeotic or’Hox’ genes. Hox genes function...

...Ann M. Kapoun; Thomas C. Kaufman ABSTRACT In Drosophila , the homeotic gene proboscipedia ( pb ) is required for the formation of the adult mouthparts. To determine the functional significance of putative pb regulatory DNA, we have performed an in vivo analysis of sequences upstream of and within...

...Stanley Y. K. Tiong; David Nash; Welcome Bender ABSTRACT The wing imaginal disc is subdivided into a dorsal and a ventral compartments. A new dominant homeotic mutation, Dorsal wing 1 ( Dlw 1 ), transforms ventral into dorsal compartment in heterozygotes. This phenotype is similar to one...

...J. Robert Manak; Laura D. Mathies; Matthew P. Scott ABSTRACT The clustered homeotic genes encode transcription factors that regulate pattern formation in all animals, conferring cell fates by coordinating the activities of downstream ‘target’ genes. In the Drosophila midgut, the Ultrabithorax ( Ubx...

... of homeotic gene expression and function. It is too soon to say whether the cases of conservation are unique and exceptional, or the beginning of a profoundly unified view of gene regulation in animal development. In any case, new questions are raised by the data: how can the differences between mammals...

...Danesh Moazed; Patrick H. O’Farrell ABSTRACT The stable maintenance of expression patterns of homeotic genes depends on the function of a number of negative trans -regulators, termed the Polycomb ( Pc ) group of genes. We have examined the pattern of expression of the Drosophila segment polarity...

...Deborah W. Cowing; Cynthia Kenyon ABSTRACT mab-5 is a member of a complex of homeobox-containing genes evolutionarily related to the Antennapedia and bithorax complexes of Drosophila melanogaster . Like the homeotic genes in Drosophila, mab-5 is required in a particular region along the anterior...