... cells to carry out functions during tissue repair and homeostasis. Stem cells Regeneration Innate immunity Trained immunity Macrophages Hemocytes Homeostasis National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R01GM132753 University...

...Pooja Flora; Elena Ezhkova ABSTRACT Cell divisions and cell-fate decisions require stringent regulation for proper tissue development and homeostasis. The mammalian epidermis is a highly organized tissue structure that is sustained by epidermal stem cells (ESCs) that balance self-renewal and cell...

.../ Highlighted Article: An optimized approach to developmental arrest of third instar Drosophila larvae offers new insights into the mechanisms of synaptic growth, function, homeostatic plasticity and neurodegeneration at a model glutamatergic synapse. Homeostasis Synapse Neurotransmission...

...Ludmila Gordon; Janna Blechman; Eyal Shimoni; Dvir Gur; Bela Anand-Apte; Gil Levkowitz ABSTRACT To maintain body homeostasis, endocrine systems must detect and integrate blood-borne peripheral signals. This is mediated by fenestrae, specialized permeable pores in the endothelial membrane...

...Marine Theret; Remi Mounier; Fabio Rossi ABSTRACT The discovery of new non-canonical (i.e. non-innate immune) functions of macrophages has been a recurring theme over the past 20 years. Indeed, it has emerged that macrophages can influence the development, homeostasis, maintenance and regeneration...

...Nicholas D. Hastie ABSTRACT The study of genes mutated in human disease often leads to new insights into biology as well as disease mechanisms. One such gene is Wilms’ tumour 1 ( WT1 ), which plays multiple roles in development, tissue homeostasis and disease. In this Primer, I summarise how...

...Joep Beumer; Hans Clevers The intestinal epithelium is the fastest renewing tissue in mammals and has a large flexibility to adapt to different types of damage. Lgr5 + crypt base columnar (CBC) cells act as stem cells during homeostasis and are essential during regeneration. Upon perturbation...

...Yutaka Takada; Akihisa Fukuda; Tsutomu Chiba; Hiroshi Seno Brg1, a core subunit of the SWI/SNF chromatin remodeling complex, is essential for development and homeostasis of various organs. However, the functional role of Brg1 in intestinal development and homeostasis, and the underlying molecular...

..., normal density is restored. Taken together, these results reveal crucial roles for both BMP signaling and cell shedding in homeostasis of the respiratory epithelium. * Present address: Department of Regenerative Medicine, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku...

... quiescent stem cell populations, but the exact roles that HH signaling plays in adult organ homeostasis and regeneration remain poorly understood. Here, we review recently identified functions of HH in modulating the behavior of tissue-specific adult stem and progenitor cells during homeostasis...

... Homeostasis Mouse The adrenal capsule is histologically characterized as arising from cells of the intermediate mesoderm. After separation of the individual adrenal primordia (AP, fetal adrenal gland) and gonadal primordial (GP) from the shared adrenogonadal primordia (AGP), mesenchymal cells...

... statement The authors declare no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Adult neurogenesis Homeostasis Neural stem cell Neurotransmitter Regeneration In the brain, signaling via neurotransmitters, small molecules released by neurons...

... regeneration. † Author for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 16 7 2008 © 2008. 2008 Blastema Fgf Fin Homeostasis Regeneration Zebrafish The capacity for organ regeneration is remarkably elevated...

... and stabilized by CSN-5. We propose the `good cop: bad cop' team of CSN-5 and KGB-1 imposes a balance on GLH-1 levels, resulting in germline homeostasis. In addition, both KGB-1 and CSN-5 bind Vasa, a Drosophila germ granule component; therefore, similar regulatory mechanisms might be conserved from worms...