... and formation of the contractile apparatus that defines functional myofibers. Homeobox genes Muscle stem cells Myogenesis Skeletal muscle Transcription factors Epigenetics Cell signaling Differentiation Summary: Differentiation of adult myoblasts requires the interaction of β-catenin...

... Diencephalon Thalamus Nuclei Homeobox genes Shh Fgf8 Mouse The patterning and growth of a particular tissue is thought to be organized by signaling molecules expressed by specialized boundary regions between tissue compartments ( Tabata,2001 ). The central nervous system (CNS) is a complex tissue...

...Zhaohui Wang; Richard S. Mann The genetic analysis of spermatogenesis in Drosophila melanogaster has led to the identification of several genes that control the onset of meiosis, spermatid differentiation, or both. We described two tightly linked and nearly identical homeobox genes of the TGIF (TG...

..., together with concealed skin domains, account for the cyclic alopecia phenotype. * Authors for correspondence (e-mail: chuong@pathfinder.usc.edu and maas@rascal.med.harvard.edu ) 2 10 2002 © 2003. 2003 Alopecia Hair cycle Hair differentiation Homeobox genes Msx2 Foxn1...

... to the formation of nuclei. Both differential homeobox gene expression and diagnostic axon tracing studies established that the most medial arc contains primordia for two major midbrain nuclei: the oculomotor complex and the red nucleus. We tested the relationship of the medial arc to oculomotor complex and red...

...Håkan Toresson; Kenneth Campbell We have examined the role of the two closely related homeobox genes Gsh1 and Gsh2 , in the development of the striatum and the olfactory bulb. These two genes are expressed in a partially overlapping pattern by ventricular zone progenitors of the ventral...

...Gezhi Hu; Hansol Lee; Sandy M. Price; Michael M. Shen; Cory Abate-Shen During development, patterning and morphogenesis of tissues are intimately coordinated through control of cellular proliferation and differentiation. We describe a mechanism by which vertebrate Msx homeobox genes inhibit...

...Takuya Tsuji; Atsushi Sato; Ichiro Hiratani; Masanori Taira; Kaoru Saigo; Tetsuya Kojima ABSTRACT During Drosophila leg development, the distal-most compartment (pretarsus) and its immediate neighbour (tarsal segment 5) are specified by a pretarsus-specific homeobox gene, aristaless , and tarsal...

... cell populations within the developing Xenopus embryo. * Author for correspondence (e-mail syevans@ucsd.edu ) 10 09 1998 20 10 1998 © 1998 by Company of Biologists 1998 Homeobox genes Heart development Microinjection Xenopus laevis XNkx2-3 XNkx2-5 Tinman...

... formation ( Charité et al., 1994 ). limb pattern formation limb development zone of polarizing activity retinoid receptor antagonists homeobox genes Hoxb-8 retinoid bone morphogenetic protein sonic hedgehog gene Vertebrate limb development begins with the specification of limb position...

... to mediate proper closure of the ventral thoracic body wall. Failure in this closure results in severe defects of the sternum. * Author for correspondence 13 09 1996 © 1996 by Company of Biologists 1996 Hox genes homeobox genes hoxb-1 hoxb-2 hoxb-4 gene targeting Moebius...

... or migration of r4 neural crest cells or defects in tissues derived from the 2nd pharyngeal arch. * Author for correspondence 12 07 1996 © 1996 by Company of Biologists 1996 Hox genes homeobox genes hoxb-1 facial nerve Bell’s Palsy Moebius Syndrome mouse development gene...

...Deborah J. Phippard; Stephen J. Weber-Hall; Paul T. Sharpe; M. Stuart Naylor; H. Jayatalake; Richard Maas; Ian Woo; Desmond Roberts-Clark; Philippa H. Francis-West; Yi-Hsin Liu; Robert Maxson; Robert E. Hill; Trevor C. Dale ABSTRACT Expression of the Msx-1 and Msx-2 homeobox genes have been shown...

... for correspondence at address 1 21 02 1996 © 1996 by Company of Biologists 1996 cardiogenesis morphogenesis homeobox genes transcriptional regulation retinoic acid receptor embryonic patterning Cardiogenesis is one of the earliest and most-critical steps during vertebrate...

...Takeshi Akasaka; Masamoto Kanno; Rudi Balling; Marco Antonio Mieza; Masaru Taniguchi; Haruhiko Koseki ABSTRACT Segment identity in both invertebrates and vertebrates is conferred by spatially restricted distribution of homeotic gene products. In Drosophila , the expression of Homeobox genes during...

.... (1994) showed evidence that anterior and posterior axial mesoderm produce signals that induce or repress Otx-2 expression, respectively. More recent studies also support this finding ( Pannese et al., 1995 ; Blitz and Cho, 1995 ). In addition, mutation of Lim-1 homeobox gene leads to complete...

... by Company of Biologists 1995 Hox genes homeobox genes Hoxa-3 neural crest pax-1 mouse development thymus thyroid DiGeorge syndrome REFERENCES Auerbach , R. ( 1960 ). Morphogenetic interactions in the development of the mouse thymus gland . Dev. Biol . 2 , 271 – 284...

... , is expressed during gastrulation in a stripe localized to the posterior region of the embryo. These observations suggest that CdxA as a homeobox gene may be part of a regulatory network coupled to axial determination during gastrulation in the early chick embryo. * Present address: Department...

... of Hox genes in vertebrate genomes. We isolated cDNA clones of two newt homeobox genes from homologous positions within two Hox clusters; Hox - 4 . 5 and Hox - 3 . 6 . We used RNase protection on nonamputated (normal) and regenerating newt appendages and tissue to com-pare their transcriptional patterns...

... 1992 by Company of Biologists 1992 Clox homeobox genes DNA binding-proteins transcription factors mouse development. Two anti-Clox antibodies were generated to investigate the pattern of expression of Clox during mouse development (see below). Rabbits were immunized with a Clox...