...: Differentiation of adult myoblasts requires the interaction of β-catenin with MyoD but not with TCF/LEF; future selective targeting of different β-catenin complexes might allow inhibition of TCF/LEF-dependent fibrosis whilst sparing myoblast differentiation. Homeobox genes Muscle stem cells Myogenesis...

... Diencephalon Thalamus Nuclei Homeobox genes Shh Fgf8 Mouse The patterning and growth of a particular tissue is thought to be organized by signaling molecules expressed by specialized boundary regions between tissue compartments ( Tabata,2001 ). The central nervous system (CNS) is a complex tissue...

...Zhaohui Wang; Richard S. Mann The genetic analysis of spermatogenesis in Drosophila melanogaster has led to the identification of several genes that control the onset of meiosis, spermatid differentiation, or both. We described two tightly linked and nearly identical homeobox genes of the TGIF (TG...

... -61. Hébert, J. M., Rosenquist, T., Gotz, J. and Martin, G. R. ( 1994 ). FGF5 as a regulator of the hair growth cycle:evidence from targeted and spontaneous mutations. Cell 78 , 1017 -1025. Hu, G., Lee, H., Price, S. M., Shen, M. M. and Abate-Shen,C. ( 2001 ). Msx homeobox genes...

... to the formation of nuclei. Both differential homeobox gene expression and diagnostic axon tracing studies established that the most medial arc contains primordia for two major midbrain nuclei: the oculomotor complex and the red nucleus. We tested the relationship of the medial arc to oculomotor complex and red...

...Håkan Toresson; Kenneth Campbell We have examined the role of the two closely related homeobox genes Gsh1 and Gsh2 , in the development of the striatum and the olfactory bulb. These two genes are expressed in a partially overlapping pattern by ventricular zone progenitors of the ventral...

...Gezhi Hu; Hansol Lee; Sandy M. Price; Michael M. Shen; Cory Abate-Shen During development, patterning and morphogenesis of tissues are intimately coordinated through control of cellular proliferation and differentiation. We describe a mechanism by which vertebrate Msx homeobox genes inhibit...

...Takuya Tsuji; Atsushi Sato; Ichiro Hiratani; Masanori Taira; Kaoru Saigo; Tetsuya Kojima ABSTRACT During Drosophila leg development, the distal-most compartment (pretarsus) and its immediate neighbour (tarsal segment 5) are specified by a pretarsus-specific homeobox gene, aristaless , and tarsal...

... cell populations within the developing Xenopus embryo. * Author for correspondence (e-mail [email protected] ) 10 09 1998 20 10 1998 © 1998 by Company of Biologists 1998 Homeobox genes Heart development Microinjection Xenopus laevis XNkx2-3 XNkx2-5 Tinman...

... limb development zone of polarizing activity retinoid receptor antagonists homeobox genes Hoxb-8 retinoid bone morphogenetic protein sonic hedgehog gene Vertebrate limb development begins with the specification of limb position and polarity, and the initiation of a limb bud. Tissue...

... to mediate proper closure of the ventral thoracic body wall. Failure in this closure results in severe defects of the sternum. * Author for correspondence 13 09 1996 © 1996 by Company of Biologists 1996 Hox genes homeobox genes hoxb-1 hoxb-2 hoxb-4 gene targeting Moebius...

... 1996 Hox genes homeobox genes hoxb-1 facial nerve Bell’s Palsy Moebius Syndrome mouse development gene targeting Mice and humans contain at least 39 Hox genes distributed on four linkage groups, designated Hox A, B, C and D, on four separate chromosomes. Based on DNA sequence...

...Deborah J. Phippard; Stephen J. Weber-Hall; Paul T. Sharpe; M. Stuart Naylor; H. Jayatalake; Richard Maas; Ian Woo; Desmond Roberts-Clark; Philippa H. Francis-West; Yi-Hsin Liu; Robert Maxson; Robert E. Hill; Trevor C. Dale ABSTRACT Expression of the Msx-1 and Msx-2 homeobox genes have been shown...

... for correspondence at address 1 21 02 1996 © 1996 by Company of Biologists 1996 cardiogenesis morphogenesis homeobox genes transcriptional regulation retinoic acid receptor embryonic patterning Cardiogenesis is one of the earliest and most-critical steps during vertebrate...

...Takeshi Akasaka; Masamoto Kanno; Rudi Balling; Marco Antonio Mieza; Masaru Taniguchi; Haruhiko Koseki ABSTRACT Segment identity in both invertebrates and vertebrates is conferred by spatially restricted distribution of homeotic gene products. In Drosophila , the expression of Homeobox genes during...

... 1995 forebrain prosencephalon pattern formation axis brain development hedgehog homeobox genes There is renewed interest in understanding the organization of the embryonic forebrain. Over the last century, prominent neuroembryologists have attempted to elucidate the primary...

... on the two sides of the same mutant animal. This variability suggests the presence of a compensating gene or genes, whose utilization is stochastic. A reasonable candidate for providing this compensatory function is the paralogous gene Hoxb-3 . Hox genes homeobox genes Hoxa-3 neural crest pax-1...

... , is expressed during gastrulation in a stripe localized to the posterior region of the embryo. These observations suggest that CdxA as a homeobox gene may be part of a regulatory network coupled to axial determination during gastrulation in the early chick embryo. * Present address: Department...

... of Hox genes in vertebrate genomes. We isolated cDNA clones of two newt homeobox genes from homologous positions within two Hox clusters; Hox - 4 . 5 and Hox - 3 . 6 . We used RNase protection on nonamputated (normal) and regenerating newt appendages and tissue to com-pare their transcriptional patterns...

... 1992 by Company of Biologists 1992 Clox homeobox genes DNA binding-proteins transcription factors mouse development. Molecular and genetic analyses have demonstrated that homeobox-containing genes play a key role in the developmental process of segmentation and specification...