...Paschalis Kratsios; Oliver Hobert ABSTRACT Homeobox genes are among the most deeply conserved families of transcription factor-encoding genes. Following their discovery in Drosophila , homeobox genes arrived on the Caenorhabditis elegans stage with a vengeance. Between 1988 and 1990, just a few...

...John L. Rubenstein; Alex S. Nord; Marc Ekker ABSTRACT The vertebrate Dlx gene family encode homeobox transcription factors that are related to the Drosophila Distal-less ( Dll ) gene and are crucial for development. Over the last ∼35 years detailed information has accrued about the redundant...

...: The NS1 homeodomain transcription factor regulates lateral organ outgrowth from shoot meristems and leaf primordial margins by repressing the expression of negative growth regulators. Maize Leaf Narrow sheath Homeobox Margin Plant leaves are typically dorsiventrally flattened and broad...

...Eric Van Otterloo; Hong Li; Kenneth L. Jones; Trevor Williams ABSTRACT The evolution of a hinged moveable jaw with variable morphology is considered a major factor behind the successful expansion of the vertebrates. DLX homeobox transcription factors are crucial for establishing the positional code...

... system. Homeodomain and basic helix-loop-helix transcription factors are required for retinogenesis, as well as patterning, differentiation and maintenance of specific retinal cell types. We hypothesized that Dlx1 , Dlx2 and Brn3b homeobox genes function in parallel intrinsic pathways to determine RGC...

... set of collaborating transcription factors. One of the collaborating transcription factors is the POU homeobox gene unc-86 , which collaborates with ttx-3 to determine the identity of the serotonergic NSM neurons. unc-86 in turn operates independently of ttx-3 in the anterior ganglion where...

...Joonsung Hwang; Taraneh Mehrani; Sarah E. Millar; Maria I. Morasso Dlx homeobox transcription factors regulate epidermal, neural and osteogenic cellular differentiation. Here, we demonstrate the central role of Dlx3 as a crucial transcriptional regulator of hair formation and regeneration...

... neuronal progenitors into multiple neuronal cell lineages. In the developing forebrain of mammals, the combined function of the Dlx1, Dlx2, Dlx5 and Dlx6 homeobox genes is necessary for the differentiation of the GABAergic interneurons born in the ventricular and subventricular zones of the ventral...

... tract (OFT)myocardium, revealed unexpected complexity in development of these muscle groups. The Pitx2 homeobox gene functions in both cranial paraxial mesoderm, to regulate eye muscle, and in splanchnic mesoderm to regulate OFT development. Here, we investigated Pitx2 in branchiomeric muscle. Pitx2...

... an unanticipated role for the enteric muscles in regulating this ultradian rhythm. * Author for correspondence (e-mail: [email protected] ) 30 8 2005 ©2005. 2005 Defecation Homeobox Paired-like Enteric muscles dsc-1 clk-1 Homeodomain transcription factors...

... limb amputation, blastema cells interpret the proximal-most positional identity in the stump to reproduce missing parts faithfully. Classical experiments showed the ability of retinoic acid (RA) to proximalize blastema positional values. Meis homeobox genes are involved in RA-dependent specification...

.... Transcriptional cascade to generate commissural neurons downstream of Math1. Fig. 9. Transcriptional cascade to generate commissural neurons downstream of Math1. Many homeobox genes are expressed downstream of proneural bHLH genes. Some homeodomain proteins are directly involved in the specification...

...Jimmy de Melo; Guoyan Du; Mario Fonseca; Leigh-Anne Gillespie; William J. Turk; John L. R. Rubenstein; David D. Eisenstat Dlx homeobox genes, the vertebrate homologs of Distal-less, play important roles in the development of the vertebrate forebrain, craniofacial structures and limbs. Members...

... epithelial regions are restricted to express region-specific subsets of OR genes. We show that progenitors and neurons express the LIM-homeobox gene Lhx2 and that neurons in Lhx2 -null mutant embryos do not diversify into subpopulations expressing different OR genes and other region-restricted genes...

...Haifa Hallaq; Emese Pinter; Josephine Enciso; James McGrath; Caroline Zeiss; Martina Brueckner; Joseph Madri; Harris C. Jacobs; Christine M. Wilson; Hemaxi Vasavada; Xiaobing Jiang; Clifford W. Bogue The homeobox gene Hhex has recently been shown to be essential for normal liver, thyroid...

...Natalia Martynova; Fedor Eroshkin; Galina Ermakova; Andrey Bayramov; Jessica Gray; Robert Grainger; Andrey Zaraisky During early development of the nervous system in vertebrates, expression of the homeobox gene Anf/Hesx1/Rpx is restricted to the anterior neural plate subdomain corresponding...

... Photoreceptor Retinal cell fate Bar Xenopus laevis Homeobox Retinal ganglion cells (RGCs) derive from a pool of virtually identical multipotent retinal progenitor cells (RPCs)( Holt et al., 1988 ; Turner et al., 1990 ; Wetts, 1988 ). RPCs differentiate according to an ordered spatiotemporal...

..., helps close off the foregut. During this time, the endoderm grows adjacent to and beyond the cardiogenic mesoderm, an inducer of the liver program and an inhibitor of the pancreas program. The homeobox gene Hex is expressed in this endoderm cell domain and in the liver and ventral pancreas buds, after...

...Chiharu Kimura-Yoshida; Kuniko Kitajima; Izumi Oda-Ishii; E Tian; Misao Suzuki; Masayuki Yamamoto; Tohru Suzuki; Makoto Kobayashi; Shinichi Aizawa; Isao Matsuo The Otx2 gene, containing a highly conserved paired -type homeobox, plays a pivotal role in the development of the rostral head throughout...

...Wei Liu; Jennifer Selever; Mei-Fang Lu; James F. Martin Pitx2 , a paired -related homeobox gene that encodes multiple isoforms, is the gene mutated in the haploinsufficient Rieger Syndrome type 1 that includes dental, ocular and abdominal wall anomalies as cardinal features. Previous analysis...