....202320599 Basson , C. T. , Cowley , G. S. , Solomon , S. D. , Weissman , B. , Poznanski , A. K. , Traill , T. A. , Seidman , J. G. and Seidman , C. E. ( 1994 ). The clinical and genetic spectrum of the Holt-Oram syndrome (heart-hand syndrome) . N. Engl. J. Med...

... microscope. * Author for correspondence (e-mail: [email protected] ) 28 4 2006 © 2006. 2006 Tbx5 Holt-Oram Syndrome Cardiogenesis Cardiac Heart Xenopus Cell cycle S-phase Proliferation T-box Hyperplastic growth of the vertebrate heart...

... in the T-box transcription factor TBX5 cause Holt-Oram syndrome (HOS), which results in forelimb and heart defects. Although mutations in TBX5 result in HOS, it has been predicted that these mutations account for only ∼30% of all individuals with HOS. Individuals with OS and HOS limb defects are very...

...Deborah M. Garrity; Sarah Childs; Mark C. Fishman Holt-Oram syndrome is one of the autosomal dominant human ‘heart-hand’ disorders, with a combination of upper limb malformations and cardiac defects. Holt-Oram syndrome is caused by mutations in the TBX5 gene, a member of a large family of T-box...

...Marko E. Horb; Gerald H. Thomsen Mutations in the Tbx5 transcription factor cause heart septal defects found in human Holt-Oram Syndrome. The complete extent to which Tbx5 functions in heart development, however, has not been established. Here we show that, in Xenopus embryos, Tbx5 is expressed...