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Keywords: Holoprosencephaly (HPE)
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Journal Articles
Journal:
Development
Development (2005) 132 (21): 4845–4855.
Published: 1 November 2005
... transcription factor and an activator of Xnr gene transcription. Taken together, our results suggest a role for maternal Zic2 in the suppression of Xnr genes in early development. ZIC2 is mutated in human holoprosencephaly (HPE), a severe defect in brain hemisphere separation,and these results strengthen...
