...-condensed chromatin state of the Xi in the mutant might give the respective antibodies easier access to their target, contributing to an increase in signal intensity. Fig. 6. Histone modification states revealed by ChIP-seq in wild-type and Smchd1 MD1/MD1 EpiSCs and MEFs. (A) Distribution...

... the major lineage decisions in vivo . By analyzing active and repressive histone modifications, we show that stem cell identity genes are silenced during differentiation by loss of their activating marks and not via repressive histone modifications. Our analysis also uncovers a new set of genes specifically...

... development remain difficult to capture. We applied a Fab-based live endogenous modification labeling technique to monitor the changes in histone modification levels during zygotic genome activation (ZGA) in living zebrafish embryos. Among various histone modifications, H3 Lys27 acetylation (H3K27ac...

.... For example, one can track histone modifications (i), GFP-labeled transcription factors (ii), and phosphorylated serine residues (Ser) in the carboxy-terminal domain (CTD) of RNA pol II that are related to recruitment, initiation and elongation (iii-v). Figure adapted from Stasevich et al. (2014) . (B) Gene...

... methylation and repressive histone modifications. Here we follow the gain of imprinted expression of Igf2r during in vitro ES cell differentiation and show that it coincides with the onset of paternal-specific expression of the Airn ncRNA. Notably, although Airn ncRNA expression leads, as predicted, to gain...

... 2007 © 2007. 2007 Primordial germ cells (PGCs) Histone modifications Reprogramming Cell cycle Epigenetics Mouse In the development of multicellular organisms, the genome of a single fertilized oocyte generates diverse cell types with distinct gene expression profiles...

... by antagonizing Su(var)3-9-mediated heterochromatization. * Author for correspondence (e-mail: kristen@iastate.edu ) 7 11 2005 © 2006. 2006 JIL-1 kinase Chromatin Histone modifications HP1 Drosophila Higher order chromatin structure is important for epigenetic...

... a striking reduction of histone modifications that correlate with transcriptional activation when compared with the genome as a whole. The histone modification spectrum on the X chromosome corresponds with a lack of transcriptional competence, as measured by reporter transgene arrays. The X chromosome in XO...