... and their inactivation reveals a role for H3K79 methylation in histone eviction during spermiogenesis. DOT1L MLLT10 Spermiogenesis Histone methylation Histone eviction National Institutes of Health National Institute of Child Health and Human Development http://dx.doi.org/10.13039...

...Brandon S. Carpenter; Teresa W. Lee; Caroline F. Plott; Juan D. Rodriguez; Jovan S. Brockett; Dexter A. Myrick; David J. Katz ABSTRACT Formation of a zygote is coupled with extensive epigenetic reprogramming to enable appropriate inheritance of histone methylation and prevent developmental delays...

.... This study contrasts KMT2D and UTX neural crest differentiation function as sources of variation in facial gestalt for Kabuki syndrome. KMT2D MLL4 Kabuki syndrome Histone methylation Neural crest Craniofacial Epigenetics play a vital role in facial development, as mutations in chromatin...

.... Meiosis Spermatogenesis Oocyte Histone methylation Chromosome Fertility CFP1 National Natural Science Foundation of China 10.13039/501100001809 31528016 31871478 31371449 31671558 National Key Research and Developmental Program of China 2016YFC1000600 2017YFC1001500...

...: Conditional inactivation of the polycomb gene Eed in nephron progenitor cells results in their premature loss and prevents normal nephron differentiation beyond the S-shaped tubule stage. Epigenetics Histone methylation Kidney development Nephron Stem cell March of Dimes Foundation...

..., metabolic processes and zygote morphology, identifying Setd1b as a key regulator of oocyte development. Histone methylation Oogenesis Pre-implantation development Transcriptional regulation Mouse Deutsche Forschungsgemeinschaft 10.13039/501100001659 KR2154/3-1 STE903/4-1...

... , R. J. , Derijck , A. A. H. A. , Perez-Burgos , L. , Kohlmaier , A. , Opravil , S. , Tachibana , M. , Shinkai , Y. , et al. ( 2003 ). Partitioning and plasticity of repressive histone methylation states in mammalian chromatin . Mol. Cell   12 , 1577 - 1589 . 10.1016...

... and autosomal genes in mammalian oocytes . Sci. Rep.   5 , 14101 . 10.1038/srep14101 Greer , E. L. and Shi , Y. ( 2012 ). Histone methylation: a dynamic mark in health, disease and inheritance . Nat. Rev. Genet.   13 , 343 - 357 . 10.1038/nrg3173 Inoue , K. , Kohda , T...

... Histone methylation Vascular development Vascular stability Endothelium Extracellular matrix Mmp9 Mouse Stability of the vasculature is essential for embryonic development and tissue homeostasis. Although the establishment of vascular cell fate, differentiation, and new vessel formation has...

... Histone methylation Bivalent promoters Trithorax group Polycomb group Kmt2 In eukaryotes, transcription is regulated not only by transcription factors that bind specific DNA sequences near the regulated gene, but also by post-translational modifications of the nucleosomes...

... A. , Greene J. , Kremmer E. , Sauer F. ( 2002 ). Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1 . Nature 419 , 857 – 862 . Bell O. , Wirbelauer C. , Hild M. , Scharf A. N. , Schwaiger M. , MacAlpine D. M. , Zilbermann...

... segregation Histone methylation Histone acetylation The fundamental unit of chromatin is the nucleosome, which is composed of two copies each of histones H2A, H2B, H3 and H4. The linker histone H1 lies adjacent to the nucleosomes and facilitates chromosome condensation to establish higher order...

... and differentiation during eye development. * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 7 5 2013 © 2013. Published by The Company of Biologists Ltd 2013 Ezh2 Histone methylation...

... no competing financial interests. 18 9 2012 © 2012. Published by The Company of Biologists Ltd 2012 Epigenetic reprogramming Histone methylation Nuclear transfer Reprogrammed cells Oocyte extract Epigenetic reprogramming is severely deficient in both somatic cell nuclear...

... ( [email protected] ) Competing interests statement 21 6 2010 © 2010. Neural development BMP pathway Epigenetic regulation Histone methylation EZH2 JMJD3 Chick neural tube During embryogenesis, multipotent neuroepithelial precursor cells originate...

... ) * These authors contributed equally to this work Competing interests statement 25 5 2010 © 2010. Bivalent chromatin Early development Histone methylation Mouse Silencing Stem cells Gene expression programmes must be tightly controlled to govern cell identity...

... and demethylation, even though histone methylation is thought to be epigenetically stable. Cumulus cell donor and the recipient oocyte were collected from BDF1 females. Nuclear transfer to MII oocytes, and oocyte activation methods were as described ( Kishigami and Wakayama,2007 ; Wakayama,2007...

[email protected] ; [email protected] ) * These authors contributed equally to this work ‡ Present address: Department of Biostatistics, University of Washington,Seattle, WA 98195, USA 8 8 2006 © 2006. 2006 C. elegans MES proteins Histone methylation Germ line X-chromosome...

... Neuenheimer Feld 280,Heidelberg, Germany 7 2 2006 © 2006. 2006 Epigenetics Histone methylation SET domain Until recently, epigenetic mechanisms have been equated with the inheritance of heterochromatin, exemplified by DNA methylation in mammals( Wolffe and Matzke, 1999...

... effect causing severe growth retardation of neonates despite `rescue' through embryonic transcription from the paternal allele. This phenotypic effect on growth could be attributed to the asymmetric localisation of the Ezh2/Eed complex and the associated histone methylation pattern to the maternal genome...