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Keywords: Hirschsprung's disease
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Journal Articles
Journal: Development
Development (2009) 136 (18): 3195–3203.
Published: 15 September 2009
... region becomes non-functional and results in a condition in humans known as Hirschsprung's disease (HSCR). One of the genes associated with HSCR is endothelin receptor type B ( Ednrb ). To study the development of colonic aganglionosis we have utilized a novel knockout mouse ( Ednrb flex3/flex3...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (9): 1681–1691.
Published: 1 May 2008
..., such as an increased capacity for proliferation, as demonstrated in vitro and in vivo,appear to underlie the ability of somite 3 NCC to form the entire ENS. 7 3 2008 © 2008. 2008 Neural crest cell Enteric nervous system Gut Hirschsprung's disease Cell migration wave-front Chick embryo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (9): 1725–1734.
Published: 1 May 2006
... system, we removed β1 integrins in the neural crest cells when they emerge from the neural tube. β1-null enteric neural crest cells fail to colonise the gut completely, leading to an aganglionosis of the descending colon, which resembles the human Hirschsprung's disease. Moreover,β1-null enteric neural...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (25): 6387–6400.
Published: 22 December 2003
... progenitors of the enteric nervous system based on their ability to form distinct neurogenic and gliogenic structures in culture. Furthermore, these experiments provide the rationale for the development of novel approaches to the treatment of congenital megacolon (Hirschsprung's disease) based...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4113–4125.
Published: 1 November 2001
...Kirsten A. Dutton; Angela Pauliny; Susana S. Lopes; Stone Elworthy; Tom J. Carney; Jörg Rauch; Robert Geisler; Pascal Haffter; Robert N. Kelsh Waardenburg-Shah syndrome combines the reduced enteric nervous system characteristic of Hirschsprung’s disease with reduced pigment cell number, although...