... attributed. Highlighted Article: YAP, an intracellular mediator of the Hippo signaling pathway, establishes epiblast competency for germ cell differentiation through activation of the WNT pathway. EpiSCs PGCs Hippo pathway Pluripotent stem cells Mouse European Research Council...

..., but can also control cell fate or tissue morphogenesis. Here, we investigate the function of the Hippo pathway during the development of cartilage, which forms the majority of the skeleton. Previously, YAP was proposed to inhibit skeletal size by repressing chondrocyte proliferation and differentiation...

... in development and maintenance of the hepatopancreatic ductal system, while providing insight into regulation of the signaling pathway. The canonical Hippo pathway is a phosphorylation cascade composed of kinases serine/threonine kinase 3 and 4 (Stk3 in zebrafish, Mst1/2 in mammals) and their scaffolding...

...Samuel A. Manning; Benjamin Kroeger; Kieran F. Harvey ABSTRACT The Hippo pathway is a highly conserved signalling pathway that regulates multiple biological processes, including organ size control and cell fate. Since its discovery, genetic and biochemical studies have elucidated several key...

... , A. , Pai , R. K. , Tun , M. and Lowe , A. W. ( 2011 ). The human adenocarcinoma-associated gene, AGR2, induces expression of amphiregulin through Hippo pathway co-activator YAP1 activation . J. Biol. Chem.   286 , 18301 - 18310 . 10.1074/jbc.M110.215707 Elbediwy , A. , Vincent...

..., presumably to allow homeostatic control of tissue repair in response to injury. In epithelia, the Hippo pathway is proposed to act as a sensor of tissue organisation ( Karaman and Halder, 2018 ). Indeed, the regulation of Yki/YAP/TAZ is intimately coupled to hallmarks of tissue architecture such as cell...

... in the Drosophila wing epithelium. MicroRNA miR-8 Drosophila Hippo pathway Brinker Cancer How organ growth is controlled is a crucial issue in developmental biology. However, we still have little understanding about the mechanisms regulating tissue size during animal development. The wing...

... been implicated in cardiac development but many questions remain. We have investigated the role of Wwtr1, a nuclear effector of the Hippo pathway, in zebrafish and find that its loss leads to reduced cardiac trabeculation. However, in mosaic animals, wwtr1 −/− cardiomyocytes contribute more frequently...

... the canonical Hippo pathway in different epithelial tissues. Cell shape Drosophila Hippo pathway Mechanosensing Yorkie The Hippo signalling pathway was discovered in Drosophila as being essential to restrict cell proliferation in growing tissues (reviewed by Badouel et al., 2009b...

... 2016. Published by The Company of Biologists Ltd 2016 Summary: This Meeting Review summarises the recent RIKEN-CDB Symposium 'Size in Development: Growth, Shape and Allometry', highlighting recent advances and open questions in the field. Hippo pathway Growth control Morphogen...

...David Jukam; Kayla Viets; Caitlin Anderson; Cyrus Zhou; Peter DeFord; Jenny Yan; Jinshuai Cao; Robert J. Johnston, Jr The Hippo pathway is crucial for not only normal growth and apoptosis but also cell fate specification during development. What controls Hippo pathway activity during cell fate...

... and minibrain are regulators of the Hippo pathway downstream of Dachsous . Nat. Cell Biol.   15 , 1176 - 1185 . 10.1038/ncb2829 Doggett , K. , Grusche , F. A. , Richardson , H. E. and Brumby , A. M. ( 2011 ). Loss of the Drosophila cell polarity regulator Scribbled promotes...

... Stroma Hippo pathway Drosophila Ft and Ds regulate PCP in the wing and eye [reviewed by Sharma and McNeill (2013) ]. Atrophin (Grunge – FlyBase) is a nuclear co-repressor that functions with Ft to regulate PCP in the Drosophila eye ( Fanto and McNeill, 2004 ). Two mammalian orthologues...

...Xaralabos Varelas Studies over the past 20 years have defined the Hippo signaling pathway as a major regulator of tissue growth and organ size. Diverse roles for the Hippo pathway have emerged, the majority of which in vertebrates are determined by the transcriptional regulators TAZ and YAP (TAZ...

... 2013. Published by The Company of Biologists Ltd 2013 Hippo pathway Cell identity maintenance Olfactory receptor Opsin Photoreceptor Sensory Multicellular organisms are able to perceive and discriminate a broad range of environmental stimuli within a number of sensory modalities...

... of the neural tube. Loss of function of FatJ promotes an increase in dp4-vp1 progenitors and a concomitant increase in differentiated Lim1 + /Lim2 + neurons. Our studies reveal that FatJ mediates its action via the Hippo pathway mediator Yap1: loss of downstream Hippo components can rescue the defect caused...

...), stimulating their proliferation. In addition, the Hippo pathway has been recently implicated in the regulation of Upd production from the ECs. Here, we show that the Hippo pathway target, Yorkie (Yki), also plays a crucial and cell-autonomous role in ISCs. Activation of Yki in ISCs is sufficient to increase...

... lacking either gene. This study highlights the complexity employed by different SWH pathway proteins to control organ size at different stages of development. © 2010. Drosophila Hippo pathway Organ size control GST-Fat was cloned and purified as described ( Yang et al., 2002...