...Nanami Goda; Yui Ito; Shun Saito; Miyabi Suzuki; Hanako Bai; Masashi Takahashi; Takuya Wakai; Manabu Kawahara ABSTRACT The Hippo pathway plays a crucial role in cell proliferation and differentiation during tumorigenesis, tissue homeostasis and early embryogenesis. Scaffold proteins from the ezrin...

... transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering . Nat. Biotechnol. 31 , 833 - 838 . 10.1038/nbt.2675 Meng , Z. , Moroishi , T. and Guan , K.-L. ( 2016 ). Mechanisms of hippo pathway regulation . Genes Dev. 30 , 1...

..., but can also control cell fate or tissue morphogenesis. Here, we investigate the function of the Hippo pathway during the development of cartilage, which forms the majority of the skeleton. Previously, YAP was proposed to inhibit skeletal size by repressing chondrocyte proliferation and differentiation...

... ). The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish . Development   145 , dev159210 . 10.1242/dev.159210 Lee , J.-H. , Kim , T.-S. , Yang , T.-H. , Koo , B.-K. , Oh , S.-P. , Lee , K.-P. , Oh , H.-J. , Lee , S.-H. , Kong , Y.-Y...

...Samuel A. Manning; Benjamin Kroeger; Kieran F. Harvey ABSTRACT The Hippo pathway is a highly conserved signalling pathway that regulates multiple biological processes, including organ size control and cell fate. Since its discovery, genetic and biochemical studies have elucidated several key...

... signaling regulates the conversion of simple columnar epithelium into stratified squamous cells in the developing mouse and human esophagus. Esophagus YAP Progenitor cells Human pluripotent stem cells 3D organoids Hippo pathway National Institutes of Health 10.13039/100000002...

...: This Development at a Glance article describes the core Hippo pathway, its regulation and the roles it plays in animal development. Cell fate Differentiation Growth Hippo pathway Morphogenesis YAP The Hippo pathway was identified using Drosophila genetic mosaic screens for genes that regulate...

... in the Drosophila wing epithelium. MicroRNA miR-8 Drosophila Hippo pathway Brinker Cancer How organ growth is controlled is a crucial issue in developmental biology. However, we still have little understanding about the mechanisms regulating tissue size during animal development. The wing...

... been implicated in cardiac development but many questions remain. We have investigated the role of Wwtr1, a nuclear effector of the Hippo pathway, in zebrafish and find that its loss leads to reduced cardiac trabeculation. However, in mosaic animals, wwtr1 −/− cardiomyocytes contribute more frequently...

... have been proposed for how Yki might respond to force. We previously proposed that the canonical upstream components of the Hippo pathway, such as apical Crb-Ex and Mer-Kib, would become diluted upon stretching of the apical domain, reducing their ability to cluster and induce transactivation of Hippo...

... ). The secretion of Igf-1 by macrophages reduces inflammation and promotes regeneration. Finally, Duojia Pan (Johns Hopkins University, Baltimore, USA) discussed recent findings that show that the Hippo pathway is activated by Toll signaling in cells of the Drosophila fat body ( Liu et al., 2016...

...David Jukam; Kayla Viets; Caitlin Anderson; Cyrus Zhou; Peter DeFord; Jenny Yan; Jinshuai Cao; Robert J. Johnston, Jr The Hippo pathway is crucial for not only normal growth and apoptosis but also cell fate specification during development. What controls Hippo pathway activity during cell fate...

... that the original work is properly attributed. Summary: In the squamous epithelium of the mouse skin, the transcription factors YAP and TAZ are regulated by integrin-Src signalling, and are required for proliferation of skin stem/progenitor cells. Hippo pathway Integrin Yes-associated protein TAZ...

... Stroma Hippo pathway Determining how organ size is regulated, and how progenitor cells self-renew, is crucial for understanding normal development. The mammalian kidney derives from three interdependent lineages: the ureteric bud (UB), which forms the collecting ducts; the nephron progenitors...

...Xaralabos Varelas Studies over the past 20 years have defined the Hippo signaling pathway as a major regulator of tissue growth and organ size. Diverse roles for the Hippo pathway have emerged, the majority of which in vertebrates are determined by the transcriptional regulators TAZ and YAP (TAZ...

... 2013. Published by The Company of Biologists Ltd 2013 Hippo pathway Cell identity maintenance Olfactory receptor Opsin Photoreceptor Sensory Multicellular organisms are able to perceive and discriminate a broad range of environmental stimuli within a number of sensory modalities...

... of the neural tube. Loss of function of FatJ promotes an increase in dp4-vp1 progenitors and a concomitant increase in differentiated Lim1 + /Lim2 + neurons. Our studies reveal that FatJ mediates its action via the Hippo pathway mediator Yap1: loss of downstream Hippo components can rescue the defect caused...

...), stimulating their proliferation. In addition, the Hippo pathway has been recently implicated in the regulation of Upd production from the ECs. Here, we show that the Hippo pathway target, Yorkie (Yki), also plays a crucial and cell-autonomous role in ISCs. Activation of Yki in ISCs is sufficient to increase...

... of GFP (green in A′-D″) and are merged with protein expression images in A″-D″. Scale bars: 20 μm. * Author for correspondence ( [email protected] ) Competing interests statement 31 12 2009 © 2010. Drosophila Hippo pathway Organ size control...