... attributed. Summary: Protein binding and genetic studies identify and characterize structural and functional motifs within the intracellular domain of Drosophila Dachsous. Dachsous DCHS1 Fat Hippo Planar cell polarity Cross-vein National Institutes of Health http://dx.doi.org...

... and found dynamic changes in Hippo-signaling components during alveologenesis. We deleted the Hippo effectors Yap/Taz from Acta2 -expressing cells at the onset of alveologenesis, causing a significant arrest in alveolar development. Using single cell RNA-seq, we identified a distinct cluster of cells...

... Quiescence Neuroblast Delta Tribbles Hippo PI3-kinase Dacapo Asymmetric cell division Cell cycle Drosophila National Institutes of Health http://dx.doi.org/10.13039/100000002 National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R01-GM120421...

... by the Hippo signalling pathway, which plays a central role in regulating organ size during development. Hippo pathway activity is mediated by the transcriptional co-factors Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which interact with TEA domain (TEAD...

.... However, the molecular mechanisms of Drosophila epithelial cell extrusion are not fully understood. Here, we report that activation of the conserved Hippo (Hpo) signaling pathway induces both apical and basal cell extrusion in the Drosophila wing disc epithelia. We show that canonical Yorkie targets Diap1...

.... The Hippo pathway is a well-conserved signaling cascade that regulates organ size and stem/progenitor cell behavior. Here, we show that Hippo signaling promotes lineage commitment of lung epithelial progenitors by curbing Fgf10 and β-catenin signaling. Our findings show that both inactivation of the Hippo...

...Chaitanya Dingare; Alina Niedzwetzki; Petra A. Klemmt; Svenja Godbersen; Ricardo Fuentes; Mary C. Mullins; Virginie Lecaudey ABSTRACT Hippo signaling is a critical pathway that integrates extrinsic and intrinsic mechanical cues to regulate organ size. Despite its essential role in organogenesis...

... is coordinated with the constraint of the chest is poorly understood. Here, we investigate the role of Hippo signaling, a cardinal pathway in organ size control, in mouse lung development. Unexpectedly, we found that epithelial loss of the Hippo kinase genes Lats1 and Lats2 ( Lats1/2 ) leads to a striking...

... of the Hippo signaling transcriptional activator Yorkie gradually decreases in the central region of the developing Drosophila wing disc. Spatial and temporal changes in Yorkie activity can be explained by changes in cytoskeletal tension and biomechanical regulators of Hippo signaling. These changes...

.... Endomitosis Endocycling Polyploid Wound Healing Hippo Huntsman Cancer Foundation Cells are considered polyploid if they possess three or more complete copies of the haploid genome. This condition can arise either through cell-cell fusion or via a process known as endoreplication...

.../user-licence-1-1/ Summary: This Review considers how tissue growth can be influenced by mechanical inputs and feedback, using the Drosophila wing disc as an example and focussing on the Hippo pathway as a key integrator of mechanical and biochemical signals. Stress Growth Mechanics...

...Xianle Shi; Zixi Yin; Bin Ling; Lingling Wang; Chang Liu; Xianhui Ruan; Weiyu Zhang; Lingyi Chen The Hippo pathway modulates the transcriptional activity of Yap to regulate the differentiation of the inner cell mass (ICM) and the trophectoderm (TE) in blastocysts. Yet how Hippo signaling...

...-distal axis in developing epithelia to regulate tissue size via the Hippo pathway and tissue shape via modulating tension at junctions. How Ds and Ft control Dachs polarisation remains unclear. Here, we identify a ubiquitin ligase, FbxL7, as a novel component of the Ds-Ft-Dachs system that is required...

... modulated remains relatively unknown. Here we show that planarians use the downstream effector of the Hippo signaling cascade, yorkie ( yki ; YAP in vertebrates) to control a diverse set of pleiotropic processes in organ homeostasis, stem cell regulation, regeneration and axial patterning. We show that yki...

...Guohui Pan; Yongqiang Feng; Abhijit A. Ambegaonkar; Gongping Sun; Matthew Huff; Cordelia Rauskolb; Kenneth D. Irvine The large atypical cadherin Fat is a receptor for both Hippo and planar cell polarity (PCP) pathways. Here we investigate the molecular basis for signal transduction downstream...

...Hitoshi Matakatsu; Seth S. Blair The giant Drosophila protocadherin Fat (Ft) affects planar cell polarity (PCP). Ft also inhibits the overgrowth of imaginal discs via the Hippo pathway, repressing the activity of the transcription co-factor Yorkie (Yki). Much of Ft activity is likely to be mediated...

...B. V. V. G. Reddy; Kenneth D. Irvine Glia perform diverse and essential roles in the nervous system, but the mechanisms that regulate glial cell numbers are not well understood. Here, we identify and characterize a requirement for the Hippo pathway and its transcriptional co-activator Yorkie...

...B. V. V. G. Reddy; Cordelia Rauskolb; Kenneth D. Irvine The Drosophila optic lobe develops from neuroepithelial cells, which function as symmetrically dividing neural progenitors. We describe here a role for the Fat-Hippo pathway in controlling the growth and differentiation of Drosophila optic...

...Yaopan Mao; Binnaz Kucuk; Kenneth D. Irvine The Fat-Hippo-Warts signaling network regulates both transcription and planar cell polarity. Despite its crucial importance to the normal control of growth and planar polarity, we have only a limited understanding of the mechanisms that regulate Fat. We...

...Hyangyee Oh; Kenneth D. Irvine Yorkie (Yki), a transcription factor of the Fat and Hippo signaling pathways, is negatively regulated by the Warts kinase. Here, we use Phos-tag gels to characterize Warts-dependent phosphorylation of Yki in vivo, and show that Warts promotes phosphorylation of Yki...