... from ptc1 –/– ; lep –/– otic vesicles. We describe how each structure within the ear was affected in detail below. Several genes encoding inhibitors of the Hh signalling pathway are expressed in and around the developing otic vesicle: these include su ( fu ), dzip1, ptc1, ptc2 and hip...

... ) to target overexpression of the Hedgehog inhibitor Hip (Huntingtin interacting protein) to block Hedgehog signaling, finding that SHH is required for proliferation of the pituitary gland. In addition, we provide evidence that Hedgehog signaling, acting at the Shh boundary within the oral ectoderm, may exert...