...Sami A. Leino; Sean C. J. Constable; Andrea Streit; David G. Wilkinson ABSTRACT Developing tissues are sequentially patterned by extracellular signals that are turned on and off at specific times. In the zebrafish hindbrain, fibroblast growth factor (Fgf) signalling has different roles at different...

... syndrome and other ciliopathies, is expressed in the hindbrain roof plate, from which the IV ventricle ChP arises, and, later, in mesenchymal cells, which give rise to the stroma and leptomeninges. Mouse Zfp423 mutants display a marked reduction of the hindbrain ChP (hChP), which: (1) fails to express...

... and actomyosin cytoskeletal changes. In this study, we demonstrate the role of Yap/Taz-TEAD activity as a sensor of mechanical signals in the regulation of the progenitor behavior of boundary cells during zebrafish hindbrain compartmentalization. Monitoring of in vivo Yap/Taz activity during hindbrain...

...Erick Martinez-Chavez; Claudia Scheerer; Andrea Wizenmann; Sandra Blaess ABSTRACT Hindbrain precerebellar neurons arise from progenitor pools at the dorsal edge of the embryonic hindbrain: the caudal rhombic lip. These neurons follow distinct migratory routes to establish nuclei that provide...

...Laura Lahti; Maarja Haugas; Laura Tikker; Mikko Airavaara; Merja H. Voutilainen; Jenni Anttila; Suman Kumar; Caisa Inkinen; Marjo Salminen; Juha Partanen Local inhibitory GABAergic and excitatory glutamatergic neurons are important for midbrain dopaminergic and hindbrain serotonergic pathways...

... control neuronal identity, but neuron-intrinsic mechanisms are required for topographic mapping in the brain. Whisker-related barrelette map Mandibular brainstem representation Topographic map Hindbrain Trigeminal ganglion Trigeminal somatotopy Edn1 Cdh13 Tbx3 Hmx1 Relay...

...Keun Lee; Isaac Skromne At the head-trunk transition, hindbrain and spinal cord alignment to occipital and vertebral bones is crucial for coherent neural and skeletal system organization. Changes in neural or mesodermal tissue configuration arising from defects in the specification, patterning...

... segment-specific cell fates. It has been unclear, however, whether Hox proteins drive the epithelial cell segregation mechanism that is thought to initiate the segmentation process. Here, we investigate the role of vertebrate Hox proteins during the partitioning of the developing hindbrain into lineage...

... that the original work is properly attributed. NRP1 VEGF Angiogenesis Arteriogenesis Retina Hindbrain NRP1 is a transmembrane receptor for the VEGF 165 isoform (VEGF 164 in mice) and the neuronal guidance cue SEMA3A, with essential roles in both vascular and neuronal development...

...Galya Kayam; Ayelet Kohl; Zohar Magen; Yuval Peretz; Karen Weisinger; Avi Bar; Orna Novikov; Claude Brodski; Dalit Sela-Donenfeld Complex patterns and networks of genes coordinate rhombomeric identities, hindbrain segmentation and neuronal differentiation and are responsible for later brainstem...

... embryos in which endogenous synthesis of all-trans RA is impaired, incubation for as little as 5 minutes in 1 nM all-trans RA (a pulse) or 5 nM 13-cis RA followed by 1-minute UV illumination is sufficient to rescue the development of the hindbrain if performed no later than bud stage. However...

...Anna Q. Cai; Kelly Radtke; Angela Linville; Arthur D. Lander; Qing Nie; Thomas F. Schilling The vitamin A derivative retinoic acid (RA) is a morphogen that patterns the anterior-posterior axis of the vertebrate hindbrain. Cellular retinoic acid-binding proteins (Crabps) transport RA within cells...

... at the core of the hindbrain developmental program. We now identify a hindbrain restricting circuit, surprisingly comprising the hindbrain inducers Wnt3a and Meis3, and Tsh1 protein. Functional and biochemical analyses show that upon Tsh1 induction by strong Wnt3a/Meis3 feedback loop activity, the Meis3-Tsh1...

.... * Authors for correspondence ( [email protected] ; [email protected] ) Competing interests statement The authors declare no competing financial interests. © 2012. Retinoids Retinoic acid Retinol dehydrogenase (RDH) Retinaldehyde dehydrogenase (RALDH) CYP26 Hindbrain Forebrain...

...Petra Stockinger; Jean-Léon Maître; Carl-Philipp Heisenberg Facial branchiomotor neurons (FBMNs) in zebrafish and mouse embryonic hindbrain undergo a characteristic tangential migration from rhombomere (r) 4, where they are born, to r6/7. Cohesion among neuroepithelial cells (NCs) has been...

... and Hamilton stage 14 [embryonic day (E) 2.5] ( Hamburger and Hamilton, 1992 ; Varela-Echavarria et al., 1996 ). Initial unbranched motor axon outgrowth occurs at stages 14-15 in a lateral direction through the neuroepithelium, with the majority of axons exiting the dorsal hindbrain by stage 17 (E3), and axon...

...Jennifer H. Gutzman; Hazel Sive We demonstrate that in the zebrafish hindbrain, cell shape, rhombomere morphogenesis and, unexpectedly, brain ventricle lumen expansion depend on the contractile state of the neuroepithelium. The hindbrain neural tube opens in a specific sequence, with initial...

..., Insm1 , as a crucial mediator of the differentiation of both subtypes, and in particular the acquisition of their neurotransmitter phenotype. Insm1 is expressed in hindbrain progenitors of monoaminergic neurons as they exit the cell cycle, in a pattern that partially overlaps with the expression...

... transcription factors play crucial roles in specifying neuron subtypes in the CN. Pancreatic transcription factor 1a (Ptf1a) and atonal homolog 1 (Atoh1)were found to be expressed in discrete dorsolateral regions of the embryonic neuroepithelia of the middle hindbrain (rhombomeres 2-5). Genetic lineage tracing...

..., and the posterior inner wall of the proctodeum( Fig. 2Q ). In more advanced tailbud embryos, XRDH10 signals were seen in distinct territories of the neural tube (including in the telencephalon, midbrain, midbrain-hindbrain boundary and spinal cord), in the olfactory system, in the eyes and ears...