... and function of the differentiation niche are regulated at the molecular level. Here, this study reveals a new role of COP9 in the differentiation niche to modulate autocrine Hedgehog (Hh) signaling, thereby promoting GSC lineage differentiation. COP9, which is a highly conserved protein complex composed...

.../STAT ligand Unpaired (Upd) and BMPs to maintain CySCs and GSCs, respectively. However, GSCs also require BMPs produced by CySCs, and as such CySCs are part of the niche for GSCs. Here we describe a role for another secreted ligand, Hedgehog (Hh), produced by niche cells, in the self-renewal of CySCs...

... microenvironment that regulates both stem cell pools. Here we show that CySC but not GSC maintenance requires Hedgehog (Hh) signalling in addition to Jak/Stat pathway activation. CySC clones unable to transduce the Hh signal are lost by differentiation, whereas pathway overactivation leads to an increase...

... declare no competing financial interests. 1 7 2011 © 2011. Fgf Hh Axial patterning Otic vesicle Zebrafish Inner ears of jawed vertebrates are highly asymmetrical about all three body axes, particularly the anteroposterior (AP) axis, along which the main vestibular...

...Hongge Jia; Yajuan Liu; Wei Yan; Jianhang Jia The seven-transmembrane protein Smoothened (Smo) and Zn-finger transcription factor Ci/Gli are crucial components in Hedgehog (Hh) signal transduction that mediates a variety of processes in animal development. In Drosophila , multiple kinases have been...

... the inductive signal Hedgehog (Hh). This inductive mechanism helps to establish an orderly arrangement of connections between the R axons and lamina neurons, termed a retinotopic map because it results in positioning the lamina neurons in close vicinity to the corresponding R axons. We found that the bHLH-PAS...

[email protected] ) 12 4 2005 ©2005. 2005 sine oculis so hedgehog hh eyes absent eya eyeless ey Ocelli Drosophila The Drosophila visual system consists of two compound eyes and three ocelli, which are simple eyes located on the adult vertex( Stark et al., 1989...

...Hongliang Hu; Matthew J. Hilton; Xiaolin Tu; Kai Yu; David M. Ornitz; Fanxin Long Signals that govern development of the osteoblast lineage are not well understood. Indian hedgehog (Ihh), a member of the hedgehog (Hh) family of proteins, is essential for osteogenesis in the endochondral skeleton...

...Michèle Crozatier; Bruno Glise; Alain Vincent Hedgehog (Hh) signalling from posterior (P) to anterior (A) cells is the primary determinant of AP polarity in the limb field in insects and vertebrates. Hh acts in part by inducing expression of Decapentaplegic (Dpp), but how Hh and Dpp together...

... polarity Morphogen Compartment Hh omb Wnt Drosophila melanogaster Planar polarity ( Nübler-Jung et al., 1987 ) refers to the orientation of cells in an epithelium with respect to the axis of the organ (e.g. proximodistal) or to the body (e.g. anteroposterior). The mechanisms...

... differently. Unlike other vertebrates, zebrafish express three hh genes in the embryonic midline: shh , echidna hedgehog ( ehh ) and tiggywinkle hedgehog ( twhh ) . Therefore, it is possible that Twhh and Ehh are sufficient for motoneuron formation in the absence of Shh. To test this hypothesis we have...