1-2 of 2
Keywords: Heterotrimeric G protein
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

The Gq/11 family of Gα subunits is necessary and sufficient for lower jaw development

Open Access
Stanley M. Kanai, Chloe R. Garcia, MaCalia R. Augustus, Shujan A. Sharafeldeen, Elliott P. Brooks, Juliana Sucharov, Ezra S. Lencer, James T. Nichols, David E. Clouthier
Journal: Development
Development (2025) 152 (8): dev204396.
https://doi.org/10.1242/dev.204396
Published: 17 April 2025
... additional signaling pathway components that are linked to human craniofacial differences. Ednra signaling is mediated by heterotrimeric G proteins, complexes composed of a Gα subunit and a Gβ/Gγ obligate heterodimer (Gβγ) ( Gilman, 1987 ). Ligand-bound Ednra facilitates the exchange of GDP for GTP...
View articletitled, The Gq/11 family of Gα subunits is necessary and sufficient for lower jaw development
Open the PDF for The Gq/11 family of Gα subunits is necessary and sufficient for lower jaw development in another window
Includes: Supplementary data
Journal Articles

Extensive crosstalk of G protein-coupled receptors with the Hedgehog signalling pathway

Free
Farah Saad, David R. Hipfner
Journal: Development
Development (2021) 148 (7): dev189258.
https://doi.org/10.1242/dev.189258
Published: 15 April 2021
...Farah Saad; David R. Hipfner ABSTRACT Hedgehog (Hh) ligands orchestrate tissue patterning and growth by acting as morphogens, dictating different cellular responses depending on ligand concentration. Cellular sensitivity to Hh ligands is influenced by heterotrimeric G protein activity, which...
View articletitled, Extensive crosstalk of G protein-coupled receptors with the Hedgehog signalling pathway
Open the PDF for Extensive crosstalk of G protein-coupled receptors with the Hedgehog signalling pathway in another window
Includes: Supplementary data