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Keywords: Heterogeneity
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Journal Articles
Journal: Development
Development (2022) 149 (8): dev200425.
Published: 3 May 2022
... of the brain. Apart from being highly specialized brain phagocytes, microglia modulate the development and functions of neurons and glial cells through both direct and indirect interactions. Thus, recognizing the elements that influence the homeostasis and heterogeneity of microglia in normal brain development...
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199950.
Published: 19 October 2021
... discussions at The Company of Biologists virtual workshop, ‘Cell State Transitions: Approaches, Experimental Systems and Models’. Cell state transitions Definition of cell states Heterogeneity Modelling The term ‘cell state transition’ refers to the process by which cells change states over...
Journal Articles
Journal: Development
Development (2018) 145 (18): dev166025.
Published: 21 September 2018
...: Asymmetric geometrical confinement guides polarised patterning and ensures positional precision of a primitive streak-like population of cells in mouse pluripotent cultures. Embryonic Heterogeneity Micropatterning Self-organisation Stem cells Mouse Developmental patterning is the process...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev155994.
Published: 28 March 2018
... development and regeneration: origins, formation, cell fate, signalling activity, interaction with the local environment and therapeutic potential. Epicardium Epicardium-derived cells Heterogeneity Lineage derivatives Migration Recruitment Cardiovascular regeneration The epicardium...
Journal Articles
Journal: Development
Development (2016) 143 (24): 4571–4581.
Published: 15 December 2016
... transplantation. The growing body of evidence that supports heterogeneity within HSCs, which constitute the most robust cell fraction at the foundation of the adult hematopoietic system, is currently of great interest and raises questions as to why HSC subtypes exist, how they are generated and whether HSC...
Journal Articles
Journal: Development
Development (2015) 142 (16): 2840–2849.
Published: 15 August 2015
... dynamics and heterogeneity, and how this regulation responds to triggers of pluripotency. Cell cycles are highly heterogeneous and cycle time increases with Nanog reporter expression, with longer, more variable cycle times as cells approach ground-state pluripotency. Nanog reporter expression is highly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (11): 2173–2181.
Published: 1 June 2014
...Maria-Elena Torres-Padilla; Ian Chambers When pluripotent cells are exposed to a uniform culture environment they routinely display heterogeneous gene expression. Aspects of this heterogeneity, such as Nanog expression, are linked to differences in the propensity of individual cells to either self...
Journal Articles
Journal: Development
Development (2014) 141 (9): 1848–1856.
Published: 1 May 2014
... and enterocyte identity during a defined window of metamorphosis. ISC heterogeneity is established prior to adulthood and then maintained in cooperation with regional signals from surrounding tissue. Our data provide a conceptual framework for how other tissues maintained by regional stem cells might...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (6): 1209–1221.
Published: 15 March 2014
... β-catenin, T(Bra) expression was completely ablated, and other PS markers strongly downregulated, in Ctnnb1 null EpiSCs ( Fig. 3C,F ). By contrast, control fl/fl-β-cat EpiSCs, like Tps/tb-RED EpiSCs, exhibited heterogeneous T(Bra) expression ( Fig. 3C,F ). However, probably because of the more...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (1988) 103 (Supplement): 95–99.
Published: 1 September 1988
... derived from the cephalic NC to the facial skeleton. Copyright © 1988 by Company of Biologists 1988 neural crest heterogeneity neurogenic population extracellular matrix fibronectin Development 103 Supplement, 95-99 (1988) Printed in Great Britain © The Company of Biologists Limited 1988 95...