... then highlight recent studies that reveal how different cells and tissues exhibit variable levels of ribosome production and protein synthesis, and how changes in protein synthesis capacity can influence specific cell fate decisions. We finish by touching upon ribosome heterogeneity in stress responses...

... the region or by knocking out DNA methyltransferases or Zfp57 , is associated with reduced heterogeneity of NANOG, delayed commitment into differentiation and impaired ability to acquire a primitive endoderm fate. Hence, a network axis centred on DNA methylation, ZFP57 and H3K9me3 links Nanog regulation...

... of the brain. Apart from being highly specialized brain phagocytes, microglia modulate the development and functions of neurons and glial cells through both direct and indirect interactions. Thus, recognizing the elements that influence the homeostasis and heterogeneity of microglia in normal brain development...

... Spotlight article summarises some of the main messages that emerged from discussions at The Company of Biologists virtual workshop, ‘Cell State Transitions: Approaches, Experimental Systems and Models’. Cell state transitions Definition of cell states Heterogeneity Modelling The term ‘cell...

... in any medium provided that the original work is properly attributed. Highlighted Article: Asymmetric geometrical confinement guides polarised patterning and ensures positional precision of a primitive streak-like population of cells in mouse pluripotent cultures. Embryonic Heterogeneity...

... development and regeneration: origins, formation, cell fate, signalling activity, interaction with the local environment and therapeutic potential. Epicardium Epicardium-derived cells Heterogeneity Lineage derivatives Migration Recruitment Cardiovascular regeneration The epicardium...

... transplantation. The growing body of evidence that supports heterogeneity within HSCs, which constitute the most robust cell fraction at the foundation of the adult hematopoietic system, is currently of great interest and raises questions as to why HSC subtypes exist, how they are generated and whether HSC...

... dynamics and heterogeneity, and how this regulation responds to triggers of pluripotency. Cell cycles are highly heterogeneous and cycle time increases with Nanog reporter expression, with longer, more variable cycle times as cells approach ground-state pluripotency. Nanog reporter expression is highly...

...Maria-Elena Torres-Padilla; Ian Chambers When pluripotent cells are exposed to a uniform culture environment they routinely display heterogeneous gene expression. Aspects of this heterogeneity, such as Nanog expression, are linked to differences in the propensity of individual cells to either self...

... and enterocyte identity during a defined window of metamorphosis. ISC heterogeneity is established prior to adulthood and then maintained in cooperation with regional signals from surrounding tissue. Our data provide a conceptual framework for how other tissues maintained by regional stem cells might...

... patterning in mouse embryos . Development 116 , 1123 – 1136 . Canham M. A. , Sharov A. A. , Ko M. S. , Brickman J. M. ( 2010 ). Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript . PLoS Biol. 8...

... heterogeneity neurogenic population extracellular matrix fibronectin The neural crest (NC) is derived from the ectoderm at the lateral borders of the neural plate and is first distinct during the later stages of neurulation when prospective NC cells segregate from the surrounding epidermal ectoderm...