... in the establishment of the stably silenced state. We propose that the H3K9me3 blocks formed on the Xi facilitate robust heterochromatin formation in combination with H3K27me3, and that the substantial loss of H3K9me3 caused by SmcHD1 deficiency leads to aberrant distribution of H3K27me3 on the Xi and derepression...

...Beste Mutlu; Huei-Mei Chen; Silvia Gutnik; David H. Hall; Sabine Keppler-Ross; Susan E. Mango ABSTRACT During the first hours of embryogenesis, formation of higher-order heterochromatin coincides with the loss of developmental potential. Here, we examine the relationship between these two events...

...Maria Ninova; Katalin Fejes Tóth; Alexei A. Aravin ABSTRACT Histone 3 lysine 9 trimethylation (H3K9me3) is a conserved histone modification that is best known for its role in constitutive heterochromatin formation and the repression of repetitive DNA elements. More recently, it has become evident...

... of the heterochromatin. In a position-effect variegation assay, we found a dominant genetic interaction between sov and HP1a, indicating their functional cooperation in promoting the spread of heterochromatin. An in vivo tethering assay and FRAP analysis revealed that Sov enhances heterochromatin formation by supporting...

... leukemia virus (MLV) elements. This induces the unfolded protein response and apoptosis, blocking B cell development. Setdb1 Heterochromatin Retrotransposon Unfolded protein response Mouse Epigenetic mechanisms regulate developmental transitions by mediating the activation or stable...

... to pericentric heterochromatin during the transition to the first mitosis. This stage is also characterized by a striking kinetochore size asymmetry established by differences in CENP-C protein between the parental genomes. Loss of ATRX results in increased centromeric mitotic recombination, a high frequency...

... somatic niche. Reprogramming is characterized by chromatin decondensation, reduction in heterochromatin, depletion of linker histones, changes in core histone variants and in histone modification landscapes. From the analysis of mutants in which the gametophyte fate is either expressed ectopically...

... and Osbpl5 upon the conditional removal of RNA at E8.5 points towards heritability of heterochromatin states comprising histone modifications. Consistent with the latter notion, it has been shown that the repressive histone modification of H3K27me3, once established over silent genes, is passed on to next...

...Yannis Jaquet; Marion Delattre; Anne Spierer; Pierre Spierer An increase in the dose of the heterochromatin-associated Su(var)3-7 protein of Drosophila augments the genomic silencing of position-effect variegation. We have expressed a number of fragments of the protein in flies to assign functions...

... is initiated at the onset of gastrulation, approximately 1 hour after heterochromatin is first visible cytologically. A high degree of silencing is maintained in the mitotically active imaginal cells from mid-embryogenesis until early third instar larval stage, and extensive relaxation of silencing is tightly...

... with heterochromatic satellite sequences which is observed throughout the cell cycle. * Authors for correspondence 25 01 1996 © 1996 by Company of Biologists 1996 GAGA Trithorax-like chromatin nuclear division heterochromatin Drosophila In addition to the nuclear cleavage...

...Kenneth D. Tartof; Marilyn Bremer ABSTRACT The study of variegating position effects in Drosophila provides a model system to explore the mechanism and material basis for the construction and developmental control of heterochromatin domains and the imprinted genomic structures that they may create...