... embryos deprived of Sox2 in the olfactory epithelium using CRISPR-Cas9, we show that Sox2 activity is crucial for the induction of the neural progenitor gene Hes5 and for subsequent differentiation of the neuronal lineage. Our results also suggest that Sox2 activity promotes the neurogenic domain...

.... Previously, we found that the Hes genes inhibit neuronal differentiation and maintain NSCs. Here, we generated transgenic mice that overexpress Hes5 in NSCs of the central nervous system, and found that the transition timing from deep to superficial layer neurogenesis was shifted earlier, while gliogenesis...

... in the mouse cochlea depends on integration of developmental signals at highly conserved regions of the Atoh1 promoter. Cochlear development Organ of Corti Hair cell regeneration Transdifferentiation Atoh1 Hes5 Mouse The auditory sensory epithelium in mammals, the organ of Corti...

... forebrain neurogenesis. Here we show that zinc finger genes Fezf1 and Fezf2 , which encode transcriptional repressors, are expressed in the early neural stem (progenitor) cells and control neurogenesis in mouse dorsal telencephalon. Fezf1 - and Fezf2 -deficient forebrains display upregulation of Hes5...

... tissue has not yet been determined. Using mouse embryos and lineage-tracing analysis, we found that the prospective choroid plexus region initially gives rise to Cajal-Retzius cells, specialized neurons that guide neuronal migration. Inactivation of the bHLH repressor genes Hes1,Hes3 and Hes5 upregulated...

... of Notch signaling components, including Jag1, Hes5 and in a manner consistent with reduced Notch signaling,and correlated with increases in hair cell and support cell differentiation. The disruption of Notch signaling by a γ-secretase inhibitor in an in vitro organ culture system of wild-type cochleae...

...Toru Kondo; Martin Raff ABSTRACT An intracellular timer in oligodendrocyte precursor cells is thought to help control the timing of their differentiation. We show here that the expression of the Hes5 and Mash1 genes, which encode neural-specific bHLH proteins, decrease and increase, respectively...

... patterns suggest that, in mammals, gcm homologues are unlikely to regulate gliogenesis. Here, we found that, in mouse retina, the bHLH gene Hes5 was specifically expressed by differentiating Müller glial cells and that misexpression of Hes5 with recombinant retrovirus significantly increased the population...

... of the developing cerebral hemisphere. In the ventricular zone of PS1 −/− mice, expression of the Notch1 downstream effector gene Hes5 is reduced and expression of the Notch1 ligand Dll1 is elevated, whereas expression of Notch1 is unchanged. The level of Dll1 transcripts is also increased in the presomitic...