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Keywords: Hereditary hemorrhagic telangiectasia
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Journal Articles
Journal: Development
Development (2016) 143 (14): 2593–2602.
Published: 15 July 2016
...Elizabeth R. Rochon; Prahlad G. Menon; Beth L. Roman Heterozygous loss of the arterial-specific TGFβ type I receptor, activin receptor-like kinase 1 ( ALK1 ; ACVRL1 ), causes hereditary hemorrhagic telangiectasia (HHT). HHT is characterized by development of fragile, direct connections between...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (16): 3403–3412.
Published: 15 August 2013
... arterial caliber at the onset of flow. Because mutations in ALK1 cause arteriovenous malformations (AVMs), our findings suggest that an impaired flow response initiates AVM development. Bmp10 Alk1/Acvrl1 Hereditary hemorrhagic telangiectasia Arteriovenous malformation Zebrafish Flow...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (8): 1573–1582.
Published: 15 April 2011
... of blood flow in their development, we analyzed AVM development in zebrafish embryos harboring a mutation in activin receptor-like kinase I ( alk1 ), which encodes a TGFβ family type I receptor implicated in the human vascular disorder hereditary hemorrhagic telangiectasia type 2 (HHT2). Our analyses...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (12): 3009–3019.
Published: 15 June 2002
... dominant disorder, hereditary hemorrhagic telangiectasia type 2, in which disruption of ACVRL1 causes vessel malformations that may result in hemorrhage or stroke. Movies available on-line A tblastn search uncovered a 3′ zebrafish EST, zehn1109 , with homology to human ACVRL1. 5′ SMART RACE (Clontech...
Includes: Multimedia, Supplementary data