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Keywords: Heparan sulfate
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Journal Articles
Journal: Development
Development (2014) 141 (22): 4354–4365.
Published: 15 November 2014
...) is required for precise orientation of a mitotic spindle in response to a Wnt cue. We find that SDN-1 is the predominant heparan sulfate (HS) proteoglycan in the early C. elegans embryo, and that loss of HS biosynthesis or of the SDN-1 core protein results in misorientation of the spindle of the ABar...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (15): 2730–2739.
Published: 1 August 2012
... by constitutive Ras activation in the epithelium but not in the mesenchyme. We further show that lacrimal gland development requires the mesenchymal expression of the heparan sulfate N -sulfation genes Ndst1 and Ndst2 but not the 6- O and 2- O -sulfation genes Hs6st1, Hs6st2 and Hs2st . Taken together...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2005) 132 (22): 5055–5068.
Published: 15 November 2005
... that encode glycosyltransferases that synthesize heparan sulfate chains. To study the relationship of the disease to mutations in these genes, we generated Ext2 -null mice by gene targeting. Homozygous mutant embryos developed normally until embryonic day 6.0, when they became growth arrested and failed...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2002) 129 (1): 61–70.
Published: 1 January 2002
...Atsushi Irie; Edwin A. Yates; Jeremy E. Turnbull; Christine E. Holt Heparan sulfate (HS), a structurally diverse molecule comprising distinct sequences of sulfated disaccharide units, is abundant in the developing brain and binds to axon guidance molecules. Addition of HS to the developing Xenopus...
Journal Articles
Journal: Development
Development (1999) 126 (4): 781–791.
Published: 15 February 1999
... through associations with heparan sulfate proteoglycans. Neuregulin accumulation in the synaptic basal lamina of neuromuscular junctions occurred significantly later, coincident with a reorganization of muscle extracellular matrix resulting in a relative concentration of heparan sulfate proteoglycans...
Journal Articles
Journal: Development
Development (1997) 124 (20): 4113–4120.
Published: 15 October 1997
... for correspondence (e-mail: selleck@ccit.arizona.edu ) 06 08 1997 © 1997 by Company of Biologists 1997 dally dpp integral membrane proteoglycans heparan sulfate Drosophila TGF-β The Transforming Growth Factor-β (TGF-β) class of secreted molecules serve as critical regulators...
Journal Articles
Journal: Development
Development (1997) 124 (13): 2623–2632.
Published: 1 July 1997
... to that of wingless .UDP-glucose dehydrogenase is required for the biosynthesis of UDP-glucuronate, which in turn is utilized in the biosynthesis of glycosaminoglycans. By rescuing the kiwi phenotype with both UDP-glucuronate and the glycosaminoglycan heparan sulfate, we show that kiwi function in the embryo...
Journal Articles
Journal: Development
Development (1994) 120 (9): 2703–2711.
Published: 1 September 1994
... differentially affected expression of early general and regionspecific mesodermal markers, suggesting that mesodermal cell fates become specified in the early embryo via at least two signaling pathways which differ in their requirements for heparan sulfate proteoglycans. Addition of soluble heparan sulfate...
Journal Articles
Journal: Development
Development (1993) 119 (Supplement): 205–212.
Published: 1 December 1993
...Merton Bernfield; Michael T. Hinkes; Richard L. Gallo ABSTRACT Recent work has made clear that heparan sulfate at the cell surface is essential for a wide variety of interactions of cells with their microenvironment, including the action of growth factors, extracellular matrix, proteases...