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Keywords: Hemodynamics
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Journal Articles
Journal: Development
Development (2020) 147 (13): dev183020.
Published: 03 July 2020
... is subject to blood flow-driven forces. Recent work has begun to elucidate the important roles of developmental pathways, valve cell heterogeneity and hemodynamics in determining the structure and function of developing valves. Furthermore, this work has revealed that many key genetic pathways...
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180091.
Published: 14 November 2019
... Article: The asymmetric activity of Bmp signaling within the superior atrioventricular canal is essential for normal looping morphogenesis of the zebrafish heart. BMP Wnt Cardiac looping Hemodynamics Zebrafish The term ‘cardiac looping’ defines a morphogenetic process during vertebrate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev162578.
Published: 17 October 2018
... required for normal PAA development, yet specific relationships between hemodynamics and remodeling remain largely unknown. Meeting this challenge is hindered by the common reductionist analysis of morphology to single idealized models, where in fact structural morphology varies substantially. Quantitative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (3): 373–386.
Published: 01 February 2016
.... Endocardium Cardiac development Hemodynamics Bmp Krüppel-like factor 2 Vegf Mechanotransduction Zebrafish Mouse The developmental origins of the endocardium have been intensely investigated, although the molecular control and the timing of endocardial cell fate specification are currently...
Journal Articles
Journal: Development
Development (2015) 142 (23): 4158–4167.
Published: 01 December 2015
... biomicroscopy and optical coherence tomography can concurrently image vascular structure and blood flow velocity, but these techniques lack the resolution to accurately calculate fluid forces such as shear stress. This is important because hemodynamic forces are biologically active and induce changes in the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (23): 4151–4157.
Published: 01 December 2015
... understudied. We recently developed a technique to simultaneously analyse flow dynamics and vascular remodelling by time-lapse microscopy in the capillary plexus of avian embryos and used this to study the hemodynamic environment present during angiogenic sprouting. We found that sprouts always form from a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (21): 4426–4434.
Published: 01 November 2013
... Pharmacie, Illkirch, France Competing interests statement The authors declare no competing financial interests. 12 8 2013 © 2013. Published by The Company of Biologists Ltd 2013 Biomechanics Blood vessels Hemodynamics Low Reynolds number Zebrafish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (9): 1717–1726.
Published: 01 May 2011
... vessels continue to express cxcr4a , whereas connection of these vessels to the arterial circulation leads to rapid downregulation of cxcr4a expression and loss of angiogenic characteristics in endothelial cells, such as filopodia formation. Together, our findings indicate that hemodynamics, in addition...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (14): 2479–2488.
Published: 15 July 2008
... defects generally prohibits the precise assignment of the role of the mutated gene product in the vasculature. In this study, we show how to distinguish between genetic defects caused by targeted inactivation of the neuropilin 1 (Nrp1) receptor and hemodynamic defects occurring in homozygous knockout...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (3): 581–592.
Published: 01 February 2004
... correspondence (e-mail: tmikaw@med.cornell.edu ) * These authors contributed equally to this work 27 10 2003 © 2004. 2004 Cardiac conduction system Optical mapping Hemodynamics Mechanosensor Conotruncal banding Gadolinium Connexin 40 Chick embryo A rhythmic heartbeat is...