... available for focal adhesions and adherens junctions, much less is known about mechanotransduction at hemidesmosomes. Here, we focus on the C. elegans plectin homolog VAB-10A, the only evolutionary conserved hemidesmosome component. In C. elegans , muscle contractions induce a mechanotransduction pathway...

... hemidesmosome formation, loss of cell-cell contacts and increased motility suggestive of epithelial to mesenchymal transition. Taken together, our findings describe a novel function for the ENTH domain protein Clint1 in epidermal development and inflammation and suggest that its deficiency in zebrafish...

... Extracellular matrix Basement membrane Hemidesmosome C. elegans Cell adhesion Fibulins are a family of five extracellular glycoproteins associated with basement membranes and elastic fibers in vertebrates( Argraves et al., 2003 ; Timpl et al., 2003 ). Defects in fibulin family members result...

... at specific sites, where it contracts broad regions of cell contact into oriented linear junctions. Some tracks organize hemidesmosomes in the overlying epidermis. Hemicentin tracks facilitate mechanosensory neuron anchorage to the epidermis, gliding of the developing gonad along epithelial basement membranes...