...Suwei Gao; Yifan Zhang; Feng Liu ABSTRACT For a long time, self-renewing and multipotent hematopoietic stem cells (HSCs) have been thought to make a major contribution to both embryonic and adult hematopoiesis. The canonical hematopoietic hierarchy illustrating HSC self-renewal and multipotency has...

... environment, highlighting their role in the regulation of normal and pathological bone development, homeostasis and repair. Osteoclast Bone development Hematopoietic stem cell Yolk sac National Institute on Aging http://dx.doi.org/10.13039/100000049 R01 AG072058 R01 AG049745...

...Xin Gao; Chunliang Xu; Noboru Asada; Paul S. Frenette ABSTRACT Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally to the bone marrow, where most HSCs reside throughout...

... system is established by hematopoietic stem cells (HSCs), which arise during development from an endothelial-to-hematopoietic transition of cells comprising the floor of the dorsal aorta. Expression of aortic runx1 has served as an early marker of HSC commitment in the zebrafish embryo, but recent...

... intraembryonic hematopoietic stem cells as a tool to define their site of origin. Proc. Natl. Acad. Sci. USA 102 , 134 -139. Bettess, M. D., Dubois, N., Murphy, M. J., Dubey, C., Roger, C.,Robine, S. and Trumpp, A. ( 2005 ). c-Myc is required for the formation of intestinal crypts but dispensable...

... derivation of emerging hematopoietic stem cells from the vessel endothelium, endothelial cells have been sorted by flow cytometry from the yolk sac and aorta and cultured in the presence of stromal cells that support human multilineage hematopoiesis. Embryonic endothelial cells were most accurately selected...

... to embryonic artery walls from a presumptive territory whose blood-forming potential exists from at least 24 days of gestation. * Author for correspondence (e-mail: [email protected] ) 03 12 1998 20 01 1999 © 1999 by Company of Biologists 1999 Hematopoietic stem cell...

... − c-kit + cells and transiently reconstituting Mac-1 lo CD4 − or Mac-1 lo CD4 lo cells. This study shows that the same populations, with similar functional activities, exist in mice whose hematopoietic systems were reconstituted by hematopoietic stem cells after lethal irradiation. We demonstrate...

... of recombinant mast cell growth factor on purified murine hematopoietic stem cells . J. Exp. Med . 173 , 1205 – 1211 . 10.1084/jem.173.5.1205 Dialynas , D. P. , Quan , Z. S. , Wall , K. A. , Pierres , A. , Quintans , J. , Loken , M. R. , Pierres , M. and Fitch , F. W...