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Keywords: Hematopoietic niche
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Journal Articles

A dual involvement of Protocadherin 18a in stromal cell development guides the formation of a functional hematopoietic niche

Anne-Lou Touret, Catherine Vivier, Anne Schmidt, Philippe Herbomel, Emi Murayama
Journal: Development
Development (2022) 149 (19): dev200278.
https://doi.org/10.1242/dev.200278
Published: 3 October 2022
.... Thus, Pcdh18a expression in SCPs is essential for the proper development of the hematopoietic niche. Fig. 3. Pcdh18a modulates cell protrusions and connections of migrating SCPs. (Aa-Ah) Time-lapse confocal images of migrating SCP leader cells from control and pcdh18a-ΔCP 106 morphant Tg (cspg4...
View article titled, A dual involvement of Protocadherin 18a in stromal cell development guides the formation of a functional <span class="search-highlight">hematopoietic</span> <span class="search-highlight">niche</span>
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Includes: Supplementary data
Journal Articles

Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche

Harleen Kaur, Shiv Kumar Sharma, Sudip Mandal, Lolitika Mandal
Journal: Development
Development (2019) 146 (24): dev178202.
https://doi.org/10.1242/dev.178202
Published: 23 December 2019
... instar larval stage, a time point that coincides with the appearance of Lar in the hematopoietic niche. We further demonstrate that Lar physically associates with InR and serves as a negative regulator for insulin signaling in the Drosophila larval hematopoietic niche. Whether Lar serves as a localized...
View article titled, Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche
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Includes: Supplementary data
Journal Articles

The many faces of hematopoietic stem cell heterogeneity

Mihaela Crisan, Elaine Dzierzak
Journal: Development
Development (2016) 143 (24): 4571–4581.
https://doi.org/10.1242/dev.114231
Published: 15 December 2016
... may arise. Hematopoiesis HSC Hematopoietic stem cells Heterogeneity Hematopoietic niche FES Netherlands Institute of Regenerative Medicine 101675 National Institutes of Health 10.13039/100000002 RO37 DK54077 European Molecular Biology Organization...
View article titled, The many faces of hematopoietic stem cell heterogeneity
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Journal Articles

Bag of Marbles controls the size and organization of the Drosophila hematopoietic niche through interactions with the Insulin-like growth factor pathway and Retinoblastoma-family protein

Tsuyoshi Tokusumi, Yumiko Tokusumi, Dawn W. Hopkins, Robert A. Schulz
Journal: Development
Development (2015) 142 (13): 2261–2267.
https://doi.org/10.1242/dev.121798
Published: 1 July 2015
... in cells of the lymph gland posterior signaling center (PSC), a cellular domain proven to function as a hematopoietic niche. Bam is expressed in PSC cells, and gene loss-of-function results in PSC overgrowth and disorganization, indicating that Bam plays a crucial role in controlling the proper development...
View article titled, Bag of Marbles controls the size and organization of the Drosophila <span class="search-highlight">hematopoietic</span> <span class="search-highlight">niche</span> through interactions with the Insulin-like growth factor pathway and Retinoblastoma-family protein
Open the PDF for Bag of Marbles controls the size and organization of the Drosophila <span class="search-highlight">hematopoietic</span> <span class="search-highlight">niche</span> through interactions with the Insulin-like growth factor pathway and Retinoblastoma-family protein in another window
Includes: Supplementary data