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Keywords: Hematopoiesis
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Journal Articles
Journal: Development
Development (2023) 150 (9): dev200500.
Published: 28 April 2023
..., to drive hemato-vascular specification. Arnt Hematopoiesis Hematovascular specification Npas4l Zebrafish National Institutes of Health R01ES026337 T32DK060445 P30ES030285 Endothelial and hematopoietic cells are derived from a common mesodermal progenitor ( Huber et al...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (24): dev200919.
Published: 14 December 2022
...Xue Zhang; Yuxi Yang; Yuxuan Wei; Qingshun Zhao; Xin Lou ABSTRACT Hematopoiesis is a highly coordinated process that generates all the body's blood cells, and perturbations in embryonic hematopoiesis may result in illnesses ranging from fetal anemia to various leukemias. Correct establishment...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (19): dev200881.
Published: 30 September 2022
... in spi2 mutants ( Fig. 4 G), suggesting that Spi2 works together with other Runx1 downstream factor(s) to regulate HSPC expansion in the CHT. In conclusion, our study identified a previously uncharacterized ETS factor Spi2 in zebrafish and revealed its essential role in definitive hematopoiesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (16): dev200534.
Published: 17 August 2022
... liver for expansion and maturation before finally colonizing the bone marrow and sustaining adult hematopoiesis ( Kieusseian et al., 2012 ). To fulfill the intense demand of short-lived mature blood cells to support the normal function of different organs, HSPCs need to be highly active to replenish...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2022) 149 (8): dev200016.
Published: 3 May 2022
... as important determinants of organ homeostasis, tissue repair, remodeling and regeneration. Although the ontogeny and function of tissue-resident macrophages has been identified as distinct from postnatal hematopoiesis, the inability to specify, in vitro , similar populations that recapitulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200200.
Published: 22 April 2022
...Donn A. Van Deren; Shrutokirti De; Ben Xu; Kayla M. Eschenbacher; Shuhua Zhang; Mario R. Capecchi ABSTRACT Previously, we have demonstrated that a subpopulation of microglia, known as Hoxb8 microglia, is derived from the Hoxb8 lineage during the second wave (E8.5) of yolk sac hematopoiesis, whereas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200139.
Published: 24 January 2022
... cells develop via IL7Rα-positive progenitors and are repopulated by transplanted adult hematopoietic stem cells; however, such TLC lymphopoiesis cannot be fully rescued in IL7Rα −/− recipient mice. Hematopoiesis IL7R Lineage tracing Hematopoietic stem cells Transplantation Tissue-resident...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199498.
Published: 18 January 2022
... fate decisions. To further interrogate definitive hematopoiesis in the CHT of vegfc loss-of-function embryos, we examined expression of the cmyb marker using WISH. Interestingly, in contrast to the decrease of cd41:gfp+ cells we observed in the CHT of vegfc crispant ( Fig. 2 A,B...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199779.
Published: 22 December 2021
... to be a crucial and under-appreciated determinant of cell-fate decision-making during hematopoiesis. Cell fate Hematopoiesis Mathematical modeling Gene regulatory network Bistability University of Southern California http://dx.doi.org/10.13039/100006034 National Science Foundation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev200216.
Published: 17 December 2021
... blood cell types in Drosophila and act as signaling centers to neighboring cells. Drosophila Intermediate progenitor Blood cell development Crystal cells Hematopoiesis Split GAL4 National Institutes of Health R01 HL-067395 R01 CA-217608 T32HL863458 K12GM106996 T32HL69766...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev197319.
Published: 15 April 2021
... The authors declare no competing or financial interests. 24 9 2020 12 3 2021 © 2021. Published by The Company of Biologists Ltd 2021 Summary: This study investigates the process of early T cell development, and how adult hematopoiesis is regulated by distinct mechanisms...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2021) 148 (1): dev194241.
Published: 11 January 2021
... microglial waves, we uncover non-overlapping roles for csf1ra and csf1rb in hematopoiesis, and identified csf1rb as an essential regulator of adult microglia development. Notably, we demonstrate that csf1rb positively regulates HSC-derived myelopoiesis, resulting in macrophage deficiency, including microglia...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (17): dev148296.
Published: 5 September 2019
..., Runx2 mice display neonatal lethality, and Runx3 knockouts have mixed survival rates depending on the model and strain used. These models initially revealed that RUNX1 is essential for definitive hematopoiesis ( Okuda et al., 1996 ; Wang et al., 1996 ), RUNX2 is crucial for skeletal development...
Journal Articles
Journal: Development
Development (2019) 146 (7): dev166819.
Published: 4 April 2019
...Rohan J. Khadilkar; Guy Tanentzapf ABSTRACT Hematopoiesis requires coordinated cell signals to control the proliferation and differentiation of progenitor cells. In Drosophila , blood progenitors, called prohemocytes, which are located in a hematopoietic organ called the lymph gland, are regulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev158162.
Published: 29 January 2018
.... , Conway , S. J. , McGrath , K. E. and Palis , J. ( 2015 ). Definitive hematopoiesis in the Yolk Sac emerges from Wnt-responsive hemogenic endothelium independently of circulation and arterial identity . Stem Cells   34 , 431 - 444 . 10.1002/stem.2213 Goldie , L. C. , Lucitti...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2415–2427.
Published: 1 July 2017
...Chen U. Zhang; Ken M. Cadigan The lymph gland (LG) is a major source of hematopoiesis during Drosophila development. In this tissue, prohemocytes differentiate into multiple lineages, including macrophage-like plasmatocytes, which comprise the vast majority of mature hemocytes. Previous studies...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1441–1449.
Published: 15 April 2017
... hematopoiesis. * Author for correspondence ( lipsick@stanford.edu ) Competing interests The authors declare no competing or financial interests. 25 7 2016 20 2 2017 © 2017. Published by The Company of Biologists Ltd 2017 http://www.biologists.com/user-licence-1-1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4571–4581.
Published: 15 December 2016
... heterogeneity affects leukemogenesis or treatment options. This Review provides a developmental overview of HSC subtypes during embryonic, fetal and adult stages of hematopoiesis and discusses the possible origins and consequences of HSC heterogeneity. Summary: This Review takes a close look...
Journal Articles
Journal: Development
Development (2016) 143 (8): 1302–1312.
Published: 15 April 2016
.... Published by The Company of Biologists Ltd 2016 Summary: A new model for understanding the earliest steps of hematopoiesis is based on the in vitro recapitulation of hemogenic endothelium commitment from quail pre-somitic mesoderm. Hemogenic endothelium Hematopoiesis Endothelium Aorta...
Includes: Supplementary data