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Keywords: Hematopoiesis
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Journal Articles
Journal: Development
Development (2021) 148 (7): dev197319.
Published: 15 April 2021
... The Company of Biologists Ltd 2021 Summary: This study investigates the process of early T cell development, and how adult hematopoiesis is regulated by distinct mechanisms that include crosstalk between gene activation, extrinsic cell signaling and epigenetic landscaping. YY1 Notch1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev194241.
Published: 11 January 2021
... microglial waves, we uncover non-overlapping roles for csf1ra and csf1rb in hematopoiesis, and identified csf1rb as an essential regulator of adult microglia development. Notably, we demonstrate that csf1rb positively regulates HSC-derived myelopoiesis, resulting in macrophage deficiency, including microglia...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (1): dev177022.
Published: 03 January 2020
... taxa. Here, we demonstrate novel PSEDN roles in vivo in Drosophila hematopoiesis and in human erythropoiesis in vitro . Using Drosophila genetics, we show that PSEDN members function with GATA to block lamellocyte differentiation and maintain the prohemocyte pool. Overexpression of human SIX1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev148296.
Published: 05 September 2019
... mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. Bone Development Hematopoiesis RUNX T cell Embryonic The RUNX family of transcription factors orchestrate various developmental and cellular processes, such as cell...
Journal Articles
Journal: Development
Development (2019) 146 (7): dev166819.
Published: 04 April 2019
...Rohan J. Khadilkar; Guy Tanentzapf ABSTRACT Hematopoiesis requires coordinated cell signals to control the proliferation and differentiation of progenitor cells. In Drosophila , blood progenitors, called prohemocytes, which are located in a hematopoietic organ called the lymph gland, are regulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev158162.
Published: 29 January 2018
....   15 , 2185 - 2199 . 10.1016/j.celrep.2016.05.001 Frame , J. M. , Fegan , K. H. , Conway , S. J. , McGrath , K. E. and Palis , J. ( 2015 ). Definitive hematopoiesis in the Yolk Sac emerges from Wnt-responsive hemogenic endothelium independently of circulation and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2415–2427.
Published: 01 July 2017
...Chen U. Zhang; Ken M. Cadigan The lymph gland (LG) is a major source of hematopoiesis during Drosophila development. In this tissue, prohemocytes differentiate into multiple lineages, including macrophage-like plasmatocytes, which comprise the vast majority of mature hemocytes. Previous studies...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1441–1449.
Published: 15 April 2017
... for normal hematopoiesis. * Author for correspondence ( lipsick@stanford.edu ) Competing interests The authors declare no competing or financial interests. 25 7 2016 20 2 2017 © 2017. Published by The Company of Biologists Ltd 2017 http://www.biologists.com/user...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4571–4581.
Published: 15 December 2016
... heterogeneity affects leukemogenesis or treatment options. This Review provides a developmental overview of HSC subtypes during embryonic, fetal and adult stages of hematopoiesis and discusses the possible origins and consequences of HSC heterogeneity. * Author for correspondence ( elaine.dzierzak@ed.ac.uk...
Journal Articles
Journal: Development
Development (2016) 143 (8): 1302–1312.
Published: 15 April 2016
.... Published by The Company of Biologists Ltd 2016 Summary: A new model for understanding the earliest steps of hematopoiesis is based on the in vitro recapitulation of hemogenic endothelium commitment from quail pre-somitic mesoderm. Hemogenic endothelium Hematopoiesis Endothelium Aorta...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3198–3209.
Published: 15 September 2015
... hematopoiesis in human ES cell differentiation cultures . Blood   109 , 2679 - 2687 . Kennedy , M. , Awong , G. , Sturgeon , C. M. , Ditadi , A. , LaMotte-Mohs , R. , Zúñiga-Pflücker , J. C. and Keller , G. ( 2012 ). T lymphocyte potential marks the emergence of definitive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2719–2724.
Published: 01 August 2015
... microscopy (scanning electron microscopy and SOX17/RUNX1 immunofluorescence) reveals morphological changes during human and mouse endothelial to hematopoietic transition at the single-cell level. Endothelium Imaging RUNX1 SOX17 Mice Human Hemogenic Hematopoiesis Endothelial-to-hematopoietic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1728–1732.
Published: 15 May 2015
...Ann C. Zovein; E. Camilla Forsberg In February 2015, over 200 scientists gathered for the Keystone Hematopoiesis meeting, which was held at the scenic Keystone Resort in Keystone, Colorado, USA. The meeting organizers, Patricia Ernst, Hanna Mikkola and Timm Schroeder, put together an exciting...
Journal Articles
Journal: Development
Development (2015) 142 (6): 1023–1027.
Published: 15 March 2015
...Paolo Bianco; Pamela G. Robey Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays. These lineages emerge in a specific sequence during embryonic development and post natal...
Journal Articles
Journal: Development
Development (2014) 141 (24): 4656–4666.
Published: 15 December 2014
... The Company of Biologists Ltd 2014 Hematopoiesis Quiescence Stem cell Somatic cells divide as they progress through the cell cycle, which is chiefly characterized by four phases: G1 (interphase), S (DNA synthesis phase), G2 (interphase) and M (mitosis phase) ( Sisken and Morasca, 1965...
Journal Articles
Journal: Development
Development (2014) 141 (12): 2391–2401.
Published: 15 June 2014
... examined differentiation potential, global gene expression patterns and Sp1 target regions in Sp1 wild-type and Sp1-deficient cells representing different stages of hematopoiesis. Sp1 −/− cells progress through most embryonic stages of blood cell development but cannot complete terminal differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (18): 3765–3776.
Published: 15 September 2013
... declare no competing financial interests. 1 7 2013 © 2013. Published by The Company of Biologists Ltd 2013 Runx1 Embryo Hematopoiesis Hemogenic endothelium Mouse Stem cells Hematopoiesis unfolds over a period of several days during murine embryogenesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (12): 2463–2467.
Published: 15 June 2013
...Madhumita Jagannathan-Bogdan; Leonard I. Zon Hematopoiesis – the process by which blood cells are formed – has been studied intensely for over a century using a variety of model systems. There is conservation of the overall hematopoietic process between vertebrates, although some differences do...
Journal Articles
Journal: Development
Development (2012) 139 (23): 4321–4329.
Published: 01 December 2012
... (VDA), the equivalent of the mammalian aorta-gonad-mesonephros (AGM). The HSPCs subsequently migrate to the caudal hematopoietic tissue (CHT) for transitory expansion and differentiation during the larval stage, and they finally colonize the kidney, where hematopoiesis takes place in adult fish. Here...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (10): 1713–1717.
Published: 15 May 2012
... by acting both within the hematopoietic niche to control its size and its activity, and within the prohemocytes to control their fate. To gain a comprehensive view of IIS/TOR function in Drosophila hematopoiesis and in light of the recent report showing that differentiated hemocytes can feedback on...
Includes: Supplementary data