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Keywords: Hematopoiesis
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Journal Articles
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Human development
Journal: Development
Development (2022) 149 (8): dev200016.
Published: 3 May 2022
... as important determinants of organ homeostasis, tissue repair, remodeling and regeneration. Although the ontogeny and function of tissue-resident macrophages has been identified as distinct from postnatal hematopoiesis, the inability to specify, in vitro , similar populations that recapitulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200200.
Published: 22 April 2022
...Donn A. Van Deren; Shrutokirti De; Ben Xu; Kayla M. Eschenbacher; Shuhua Zhang; Mario R. Capecchi ABSTRACT Previously, we have demonstrated that a subpopulation of microglia, known as Hoxb8 microglia, is derived from the Hoxb8 lineage during the second wave (E8.5) of yolk sac hematopoiesis, whereas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200139.
Published: 24 January 2022
... on hematopoietic progenitor cells ( Fig. 7 A) ( Mackarehtschian et al., 1995 ; Christensen and Weissman, 2001 ; Schlenner et al., 2010 ; Boyer et al., 2011 ). In addition, we found that HSC competition can greatly influence the perceived ability to reconstitute hematopoiesis: when transplanted alone, adult HSCs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199498.
Published: 18 January 2022
... ). Foxn4 directly regulates tbx2b expression and atrioventricular canal formation . Genes Dev 22 , 734 - 739 . 10.1101/gad.1629408 Ciau-Uitz , A. , Monteiro , R. , Kirmizitas , A. and Patient , R. ( 2014 ). Developmental hematopoiesis: Ontogeny, genetic programming...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199779.
Published: 22 December 2021
... to be a crucial and under-appreciated determinant of cell-fate decision-making during hematopoiesis. Cell fate Hematopoiesis Mathematical modeling Gene regulatory network Bistability University of Southern California http://dx.doi.org/10.13039/100006034 National Science Foundation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev200216.
Published: 17 December 2021
... blood cell types in Drosophila and act as signaling centers to neighboring cells. Drosophila Intermediate progenitor Blood cell development Crystal cells Hematopoiesis Split GAL4 National Institutes of Health R01 HL-067395 R01 CA-217608 T32HL863458 K12GM106996 T32HL69766...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev197319.
Published: 15 April 2021
... The authors declare no competing or financial interests. 24 9 2020 12 3 2021 © 2021. Published by The Company of Biologists Ltd 2021 Summary: This study investigates the process of early T cell development, and how adult hematopoiesis is regulated by distinct mechanisms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev194241.
Published: 11 January 2021
... microglial waves, we uncover non-overlapping roles for csf1ra and csf1rb in hematopoiesis, and identified csf1rb as an essential regulator of adult microglia development. Notably, we demonstrate that csf1rb positively regulates HSC-derived myelopoiesis, resulting in macrophage deficiency, including microglia...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (1): dev177022.
Published: 3 January 2020
... taxa. Here, we demonstrate novel PSEDN roles in vivo in Drosophila hematopoiesis and in human erythropoiesis in vitro . Using Drosophila genetics, we show that PSEDN members function with GATA to block lamellocyte differentiation and maintain the prohemocyte pool. Overexpression of human SIX1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev148296.
Published: 5 September 2019
... mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. Bone Development Hematopoiesis RUNX T cell Embryonic The RUNX family of transcription factors orchestrate various developmental and cellular processes, such as cell...
Journal Articles
Journal: Development
Development (2019) 146 (7): dev166819.
Published: 4 April 2019
...Rohan J. Khadilkar; Guy Tanentzapf ABSTRACT Hematopoiesis requires coordinated cell signals to control the proliferation and differentiation of progenitor cells. In Drosophila , blood progenitors, called prohemocytes, which are located in a hematopoietic organ called the lymph gland, are regulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev158162.
Published: 29 January 2018
.... , Conway , S. J. , McGrath , K. E. and Palis , J. ( 2015 ). Definitive hematopoiesis in the Yolk Sac emerges from Wnt-responsive hemogenic endothelium independently of circulation and arterial identity . Stem Cells   34 , 431 - 444 . 10.1002/stem.2213 Goldie , L. C. , Lucitti...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2415–2427.
Published: 1 July 2017
...Chen U. Zhang; Ken M. Cadigan The lymph gland (LG) is a major source of hematopoiesis during Drosophila development. In this tissue, prohemocytes differentiate into multiple lineages, including macrophage-like plasmatocytes, which comprise the vast majority of mature hemocytes. Previous studies...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1441–1449.
Published: 15 April 2017
... hematopoiesis. In order to test whether H2AV was also required within cells of the PSC for normal prohemocyte differentiation, we drove UAS-His2Av RNAi and UAS-GFP expression with an Antp-GAL4 driver that is expressed in the PSC cells but not in the other cells of the lymph gland ( Mandal et al., 2007...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4571–4581.
Published: 15 December 2016
... heterogeneity affects leukemogenesis or treatment options. This Review provides a developmental overview of HSC subtypes during embryonic, fetal and adult stages of hematopoiesis and discusses the possible origins and consequences of HSC heterogeneity. Adult bone marrow HSCs are also controlled by TGFβ...
Journal Articles
Journal: Development
Development (2016) 143 (8): 1302–1312.
Published: 15 April 2016
.... Published by The Company of Biologists Ltd 2016 Summary: A new model for understanding the earliest steps of hematopoiesis is based on the in vitro recapitulation of hemogenic endothelium commitment from quail pre-somitic mesoderm. Hemogenic endothelium Hematopoiesis Endothelium Aorta...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3198–3209.
Published: 15 September 2015
... Hematopoiesis Endothelium Human embryonic stem cell Differentiation The anterior-posterior axis is the earliest to form in the embryo and is evolutionarily most ancient ( Kimelman and Martin, 2012 ). Anterior primitive streak gives rise to endoderm, whereas the mid- to posterior primitive streak...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2719–2724.
Published: 1 August 2015
...-cell level. Endothelium Imaging RUNX1 SOX17 Mice Human Hemogenic Hematopoiesis Endothelial-to-hematopoietic transition Scanning electron microscopy Endothelial-to-hematopoietic transition (EHT) during embryogenesis provides the first long-term hematopoietic stem and progenitor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1728–1732.
Published: 15 May 2015
...Ann C. Zovein; E. Camilla Forsberg In February 2015, over 200 scientists gathered for the Keystone Hematopoiesis meeting, which was held at the scenic Keystone Resort in Keystone, Colorado, USA. The meeting organizers, Patricia Ernst, Hanna Mikkola and Timm Schroeder, put together an exciting...
Journal Articles
Journal: Development
Development (2015) 142 (6): 1023–1027.
Published: 15 March 2015
...Paolo Bianco; Pamela G. Robey Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays. These lineages emerge in a specific sequence during embryonic development and post natal...