... GPCRs may crosstalk with the Hh pathway in mammals. References Apionishev , S. , Katanayeva , N. M. , Marks , S. A. , Kalderon , D. and Tomlinson , A. ( 2005 ). Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction . Nat. Cell Biol. 7...

...: James Briscoe Competing interests The authors declare no competing or financial interests. 4 5 2020 14 1 2021 © 2021. Published by The Company of Biologists Ltd 2021 Summary: Loss of Gpr161 leads to reduced PKA activity and derepression of Hedgehog signalling...

... with cellular homeostasis and animal development. This theme was central to Suzanne Eaton's research in the fruit fly, Drosophila . Here, we discuss her work on membrane lipid homeostasis in changing environments and on functions for lipids in the Hedgehog signalling pathway. We further highlight lipoproteins...

... regulation during development, and participates in microglia and/or macrophage transition from highly to faintly ramified morphology during myelin repair . Myelin Oligodendrocyte Axon Hedgehog signalling Fondation pour l'Aide á la Recherche sur la Sclérose en Plaques 10.13039/100007379...

... 10 2015 15 12 2015 © 2016. Published by The Company of Biologists Ltd 2016 Summary: This poster article reviews our current understanding of Hedgehog signalling mechanisms in metazoan development. Drosophila Hedgehog signalling Vertebrate Hedgehog (Hh) signalling...

.... * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 15 9 2011 © 2011. Talpid3 Zebrafish Primary cilium Cystic kidney Hedgehog signalling Gli2 processing Ciliopathy...

... limb mesenchyme results in polydactyly and in brachydactyly and a failure of subperisoteal bone formation, defects that are attributable to abnormal sonic hedgehog and Indian hedgehog signalling, respectively. Like talpid 3 chicken limbs, the mutant mouse limbs are syndactylous with uneven digit...

... ciliogenesis and Hh signalling. † Author for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 11 12 2008 © 2009. 2009 Primary cilia Centrosome Hedgehog signalling Ciliopathies Talpid3 Chicken Neural tube Embryo...

... formation Wnt canonical signalling β-catenin Tcf/Lef1 transcription factors Hedgehog signalling Gli transcription factors Gli3 locus Mouse Chick Distinct types of neuron are generated along the dorsal ventral (DV) axis of the developing spinal cord. Neurons that process and relay sensory...

... blot analysis. We conclude that Evc is an intracellular component of the hedgehog signal transduction pathway that is required for normal transcriptional activation of Ihh target genes. Evc +/- mice have no discernable defects. Offspring from heterozygous Evc +/- crosses were genotyped at E18.5...

... 2004 ©2005. 2005 Midline development Hedgehog signalling Zebrafish The floorplate is a band of non-neuronal cells in the ventral neural tube that acts as an organising centre to pattern the ventral CNS( Strähle et al., 2004 ). At early stages, the floorplate is a source...

... that OLPs in the telencephalon, possibly even some of those in the cortex, develop under the influence of SHH in the ventral forebrain. ‡Author for correspondence (e-mail: [email protected] ) 10 4 2001 © 2001. 2001 Telencephalon Hedgehog signalling Oligodendrocyte Rat...