.... and Tomlinson , A. ( 2005 ). Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction . Nat. Cell Biol. 7 , 86 - 92 . 10.1038/ncb1210 Aza-Blanc , P. , RamírezWeber , F.-A. , Laget , M.-P. , Schwartz , C. and Kornberg , T. B. ( 1997...

... ). Hedgehog signalling Gpr161 PKA Cilia Zebrafish Summary: Loss of Gpr161 leads to reduced PKA activity and derepression of Hedgehog signalling in zebrafish. Additionally, PKA-mediated phosphorylation of Gpr161 controls its ciliary localisation to fine-tune Hedgehog signalling activity. ©...

... with cellular homeostasis and animal development. This theme was central to Suzanne Eaton's research in the fruit fly, Drosophila . Here, we discuss her work on membrane lipid homeostasis in changing environments and on functions for lipids in the Hedgehog signalling pathway. We further highlight lipoproteins...

... al., 2016 ; Franklin and Ffrench-Constant, 2017 ). Myelin Oligodendrocyte Axon Hedgehog signalling Summary: The Sonic hedgehog receptor Boc is implicated in oligodendrogenesis and axon calibre regulation during development, and participates in microglia and/or macrophage...

... embryonic lung growth and morphogenesis . Development   124 , 53 - 63 . Brennan , D. , Chen , X. , Cheng , L. , Mahoney , M. and Riobo , N. A. ( 2012 ). Noncanonical Hedgehog signaling . Vitam. Horm.   88 , 55 - 72 . 10.1016/B978-0-12-394622-5.00003-1 Briscoe , J...

... talpid3 gene encodes a novel protein essential for Hedgehog signaling . Genes Dev. 20 , 1365 – 1377 . Doyon Y. , McCammon J. M. , Miller J. C. , Faraji F. , Ngo C. , Katibah G. E. , Amora R. , Hocking T. D. , Zhang L. , Rebar E. J. , et al...

... limb mesenchyme results in polydactyly and in brachydactyly and a failure of subperisoteal bone formation, defects that are attributable to abnormal sonic hedgehog and Indian hedgehog signalling, respectively. Like talpid 3 chicken limbs, the mutant mouse limbs are syndactylous with uneven digit...

... 3 mutant cells to gain insights into why ciliogenesis fails. † Author for correspondence (e-mail: cat24@bath.ac.uk ) * These authors contributed equally to this work 11 12 2008 © 2009. 2009 Primary cilia Centrosome Hedgehog signalling Ciliopathies Talpid3...

... 10 2007 © 2008. 2008 Spinal cord Neural development Pattern formation Wnt canonical signalling β-catenin Tcf/Lef1 transcription factors Hedgehog signalling Gli transcription factors Gli3 locus Mouse Chick Distinct types of neuron are generated along the dorsal ventral...

... blot analysis. We conclude that Evc is an intracellular component of the hedgehog signal transduction pathway that is required for normal transcriptional activation of Ihh target genes. Upregulation of Ptch1 and Gli1 expression has previously been observed in cells outlining the cartilage growth...

... product is required for Hedgehog signal transduction and the development of slow muscle identity. Development 127 , 2189 -2199. Barth, K. A. and Wilson, S. W. ( 1995 ). Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal...

... that OLPs in the telencephalon, possibly even some of those in the cortex, develop under the influence of SHH in the ventral forebrain. ‡Author for correspondence (e-mail: w.richardson@ucl.ac.uk ) 10 4 2001 © 2001. 2001 Telencephalon Hedgehog signalling Oligodendrocyte Rat...