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Keywords: Hedgehog signaling
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Journal Articles
Journal: Development
Development (2021) 148 (19): dev199867.
Published: 4 October 2021
... in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network . Development 135 , 2489 - 2503 . 10.1242/dev.009324 Dorn , K. V. , Hughes , C. E. and Rohatgi , R. ( 2012 ). A smoothened-Evc2 complex transduces the hedgehog signal at primary cilia . Dev...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev185678.
Published: 2 September 2020
... mesenchymal cells ( Sato et al., 2011 ; Clevers, 2013 ). Intestinal stem cell Wnt signaling Mesenchymal cell Hedgehog signaling MAPK Summary: Erk/MAPK signaling plays a crucial role during intestinal development through modulation of the Wnt signaling pathway by both cell-autonomous...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (10): dev166892.
Published: 15 May 2019
... in development and disease. Cholesterol Hedgehog signaling Morphogen Patched Primary cilium Smoothened Secreted hedgehog (HH) ligands are paracrine signaling factors that mediate communication between cells over distances as large as several hundred microns ( Lewis et al., 2001 ). The first...
Journal Articles
Journal: Development
Development (2018) 145 (24): dev165381.
Published: 18 December 2018
... for the Weizmann Institute of Science-Clalit Program. Deposited in PMC for release after 12 months. References Ahn , S. and Joyner , A. L. ( 2004 ). Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning . Cell   118 , 505 - 516 . 10.1016/j.cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (22): dev165068.
Published: 19 November 2018
.... , Fischer , N. , Rastegar , S. and Strähle , U. ( 2007 ). Cooperation of sonic hedgehog enhancers in midline expression . Dev. Biol.   301 , 578 - 589 . 10.1016/j.ydbio.2006.11.004 Evangelista , M. , Tian , H. and de Sauvage , F. J. ( 2006 ). The hedgehog signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev167221.
Published: 21 September 2018
...-1/ Summary: Hedgehog shedding, the proteolytic cleavage of Hedgehog morphogens, is required for tissue patterning and anterior/posterior compartment boundary maintenance in vivo in Drosophila melanogaster . Drosophila melanogaster Wing patterning Hedgehog signaling Cardin...
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Journal Articles
Journal: Development
Development (2018) 145 (18): dev164830.
Published: 20 September 2018
... interests The authors declare no competing or financial interests. 21 2 2018 12 7 2018 © 2018. Published by The Company of Biologists Ltd 2018 http://www.biologists.com/user-licence-1-1/ Summary: Activation of hedgehog signaling contributes to the joint calcification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev162586.
Published: 6 August 2018
... and regeneration in the hemichordate, Ptychodera flava . Zool. Sci.   32 , 33 - 37 . 10.2108/zs140157 Bain , V. E. , Gordon , J. , O'Neil , J. D. , Ramos , I. , Richie , E. R. and Manley , N. R. ( 2016 ). Tissue-specific roles for sonic hedgehog signaling in establishing thymus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (14): 2584–2594.
Published: 15 July 2017
... . Dev. Biol.   379 , 167 - 181 . 10.1016/j.ydbio.2013.04.015 Zadorozny , E. V. , Little , J. C. and Kalderon , D. ( 2015 ). Contributions of Costal 2-Fused interactions to Hedgehog signaling in Drosophila . Development   142 , 931 - 942 . 10.1242/dev.112904 Zhu , C.-H...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1544–1553.
Published: 15 April 2017
... 2017 http://www.biologists.com/user-licence-1-1/ Summary: IFT56 is key for the integrity and function of intraflagellar transport in cilia, and, consequently, for vertebrate development. IFT56 TTC26 Cilia Intraflagellar transport IFTB Hedgehog signaling Microtubule structure...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1317–1327.
Published: 1 April 2017
... and branching, but did not phenocopy transgenic expression of activated smoothened ( SmoM2 ). The epithelium showed no evidence of canonical hedgehog signaling, and hyperproliferation was not blocked by smoothened (SMO) inhibition, suggesting a non-canonical function of PTCH1. Consistent with this possibility...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1165–1176.
Published: 1 April 2017
... article: In the regenerating zebrafish fin, local Hedgehog signalling between basal epidermal cells and osteoblast progenitors controls ray branching and hence skeletal patterning. Fig. 6. Shha-driven Smoothened signaling directs progenitor osteoblasts to migrate in step with transiently split...
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (5): 856–865.
Published: 1 March 2017
... dysregulates transcription of the Hedgehog-related genes wrt-8 and grl-16 , the overexpression of which is sufficient to induce the axonal defects. Deficiency of either wrt-8 or grl-16 , or reduced expression of homologs of genes promoting Hedgehog signaling, restores correct axon guidance in jmjd-1.2 mutants...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 3944–3955.
Published: 1 November 2016
.... Hedgehog signaling Sufu Rusc Gli Xenopus Mouse Human Rusc2 was identified from a yeast two-hybrid screen using full-length Sufu as bait. To verify the interaction between Sufu and Rusc2, we performed a co-immunoprecipitation (CoIP) in HEK293T cells. We were able to co-immunoprecipitate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (12): 2194–2202.
Published: 15 June 2015
... of E18.5 dorsal skin. A minimum of 100 hair follicles were analyzed. Scale bars: 100 µm. Hedgehog signaling is required for the crosstalk between follicular keratinocytes and dermal papilla cells during hair follicle development. Activation of the Hh signaling pathway requires the primary cilia...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1651–1660.
Published: 1 May 2015
...Jinling Liu; Huiqing Zeng; Aimin Liu Hedgehog signaling is crucial for vertebrate development and physiology. Gli2, the primary effector of Hedgehog signaling, localizes to the tip of the primary cilium, but the importance of its ciliary localization remains unclear. We address the roles of Gli2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (18): 3445–3457.
Published: 15 September 2014
... ( joynera@mskcc.org ) Competing interests The authors declare no competing financial interests. © 2014. Published by The Company of Biologists Ltd 2014 Adult stem cells Hedgehog signaling Homeostasis During vertebrate development, hedgehog (HH) signaling plays an essential role...
Journal Articles
Journal: Development
Development (2014) 141 (15): 3003–3012.
Published: 1 August 2014
... found disruptions in Hedgehog signaling. Post-translational processing of GLI2 and GLI3 was aberrant in the developing facial prominences. Although both GLI2 and GLI3 processing were disrupted in talpid 2 mutants, only GLI3 activator levels were significantly altered in the nucleus. Through additional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (18): 3848–3857.
Published: 15 September 2013
.... , Biesecker L. G. , Griffith A. J. , Kelley M. W. ( 2008 ). Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans . J. Neurosci. 28 , 7350 – 7358 . Hamaguchi K. , Yamamoto N. , Nakagawa T. , Furuyashiki T. , Narumiya S...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2371–2380.
Published: 1 July 2012
.... A. , Vortkamp A. ( 2006 ). Hedgehog signaling in skeletal development . Birth Defects Res. C Embryo Today 78 , 267 – 279 . Flores M. V. , Tsang V. W. , Hu W. , Kalev-Zylinska M. , Postlethwait J. , Crosier P. , Crosier K. , Fisher S. ( 2004 ). Duplicate...
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