.../Hedgehog balance results in a low level of quiescence. Activated RSCs proliferate slowly. (B) Upon NOX inhibition, the activity of Wnt signalling drops, and that of the Hedgehog pathway increases. As a consequence, more RSCs are pushed towards quiescence. This is associated with an apparent increase...

... of the Hedgehog pathway at different stages of retinogenesis, we activated the pathway by injecting a dominant-negative form of PKA or blocking it by treating embryos with cyclopamine. Embryos injected or treated at early stages display clear proximodistal defects in the retina. Interestingly, the main phenotype...