... morphology analyses of epicardial development reveal a new role for Wt1 in the control of epicardial cell morphology and maturation through regulation of the Bmp4 signalling pathway. Epicardium Wt1 BMP4 Heart morphogenesis Cell shape Mesothelium Mouse Detailed knowledge...

... of the heart-specific generator of asymmetry, potentially downstream of the node, could cause congenital heart defects such as isolated segmental defects or discordance between cardiac segments. Deciphering the molecular cascade controlling asymmetric heart morphogenesis, beyond the left-right organiser...

.... C. , Price B. M. J. , Smith J. C. , Conlon F. L. ( 2005 ). Tbx5 and Tbx20 act synergistically to control vertebrate heart morphogenesis . Development 132 , 553 - 563 . 10.1242/dev.01596 Chaoui R. , Heling K.-S. , Sarioglu N. , Schwabe M. , Dankof...

... Neural crest Heart morphogenesis Epithelial-mesenchymal transition (EMT) is an evolutionarily conserved developmental process that contributes to the formation of the body plan, histogenesis and organogenesis. In the late 19th century, mesenchymal and epithelial cells were recognized...

... negative modulation of Fn1 levels. * Author for correspondence ( [email protected] ) 16 7 2010 © 2010. 2010 Zebrafish Heart morphogenesis Lateral plate mesoderm Hand2 Fibronectin To create the embryonic heart tube, bilateral groups of cardiomyocytes move towards...

... ) Forelimb ZPA Shh Fgf8 Tbx1 Pharyngeal epithelium Heart morphogenesis Sensory vibrissae © 2007. 2007 14 9 2007 * Authors for correspondence (e-mails: [email protected] ; [email protected] ) Embryos were fixed overnight in 4% paraformaldehyde...

...Satoshi Kitajima; Atsuya Takagi; Tohru Inoue; Yumiko Saga ABSTRACT The transcription factors, MesP1 and MesP2, sharing an almost identical bHLH motif, have an overlapping expression pattern during gastrulation and somitogenesis. Inactivation of the Mesp1 gene results in abnormal heart morphogenesis...

...Yumiko Saga; Sachiko Miyagawa-Tomita; Atsuya Takagi; Satoshi Kitajima; Jun-ichi Miyazaki; Tohru Inoue The Mesp1 gene encodes the basic HLH protein MesP1 which is expressed in the mesodermal cell lineage during early gastrulation. Disruption of the Mesp1 gene leads to aberrant heart morphogenesis...

... of the cardiac defects in Tll1 −/− embryos may be due to the failure to process some, as yet unidentified, nonfibrillar matrix substrate(s) of mTLL-1. If so, mTLL-1 may normally influence heart morphogenesis through coordinated effects on the potentiation of TGFβ-like molecules and the deposition of matrix...

...-mail: [email protected] and [email protected] ) 12 11 1998 02 10 1998 © 1998 by Company of Biologists 1998 Development Turning Heart morphogenesis Endoderm TGFβ Processing Mouse Specific proteolytic modifications are a powerful means by which...