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Keywords: Heart development
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Journal Articles
Journal: Development
Development dev.199628.
Published: 24 May 2021
... reproduction in any medium provided that the original work is properly attributed. Long Non-Coding RNA Polycomb Repressive Complex 2 Cardiac Differentiation Heart Development Pluripotent Stem Cells LncRNA HBL1 is Required for Genome-Wide PRC2 Occupancy and Function in Development Accepted...
Journal Articles
Journal: Development
Development (2021) 148 (8): dev199026.
Published: 16 April 2021
...Mingjie Xu; Jie Yao; Yingchao Shi; Huijuan Yi; Wukui Zhao; Xinhua Lin; Zhongzhou Yang ABSTRACT Mammalian heart development relies on cardiomyocyte mitochondrial maturation and metabolism. Embryonic cardiomyocytes make a metabolic shift from anaerobic glycolysis to oxidative metabolism by mid...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev191320.
Published: 05 March 2021
... Extracellular matrix Heart development Heart regeneration Heart development is a highly complex process requiring tight spatiotemporal coordination of multiple chemical and physical signals to shape heart morphology and support cardiac function. Vertebrate heart morphogenesis is initiated during...
Journal Articles
Journal: Development
Development (2020) 147 (21): dev194233.
Published: 21 October 2020
... the development of the heart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic insights into congenital heart defects. In more recent years, the lessons learned from studying heart development have been applied to interrogating regeneration of the diseased...
Journal Articles
Journal: Development
Development (2020) 147 (20): dev188706.
Published: 15 October 2020
... in the cardiac regeneration response to injury. Cardiac neural crest cells Cardiac specification Myocardium Heart development Cardiac regeneration Neural crest cells (NCCs) are a multipotential population of cells unique to vertebrates that arise after delamination from the dorsal...
Journal Articles
Journal: Development
Development (2020) 147 (12): dev185900.
Published: 17 June 2020
... that drive the essential cellular mechanisms responsible for creating the specific dimensions of the cardiac outflow tract. Zebrafish Outflow tract Endocardium Acvrl1 Cardiac function Heart development Organs are sculpted in a dynamic physical environment, where they are pulled...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (5): dev185652.
Published: 02 March 2020
...Andrew Holowiecki; Kelsey Linstrum; Padmapriyadarshini Ravisankar; Kashish Chetal; Nathan Salomonis; Joshua S. Waxman ABSTRACT Vertebrate heart development requires the integration of temporally distinct differentiating progenitors. However, few signals are understood that restrict the size of the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev174441.
Published: 13 December 2019
... expression in epicardium during human heart development. Our data suggest that it is an upstream regulator of a transcriptional hierarchy regulating cell identity in the developing epicardium. Previous studies on epicardium have suggested cellular heterogeneity based on its multifunctionality (reviewed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev185314.
Published: 09 December 2019
... computationally identified nine murine lincRNAs that have developmentally regulated transcriptional and epigenomic profiles specific to early heart differentiation. Six of the nine lincRNAs had in vivo expression patterns supporting a potential function in heart development, including a transcript downstream of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev176198.
Published: 04 July 2019
... remain challenging. Here, using multiple knockout mouse models and single cell RNA sequencing, we demonstrate that the divergent lncRNA Hand2os1 / Uph has a key complex modulatory effect on the expression of its neighboring gene HAND2 and subsequently on heart development and function. Short deletion of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174961.
Published: 04 July 2019
..., plays key roles in heart development and regeneration. During embryogenesis, the epicardium arises from the proepicardium (PE), a cell cluster that appears in the dorsal pericardium (DP) close to the venous pole of the heart. Little is known about how the PE emerges from the pericardial mesothelium...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev170753.
Published: 01 February 2019
...Noelia Muñoz-Martín; Rocío Sierra; Thomas Schimmang; Cristina Villa del Campo; Miguel Torres ABSTRACT Myc is considered an essential transcription factor for heart development, but cardiac defects have only been studied in global Myc loss-of-function models. Here, we eliminated Myc by recombining a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (22): dev167510.
Published: 21 November 2018
...Natalie Gibb; Savo Lazic; Xuefei Yuan; Ashish R. Deshwar; Meaghan Leslie; Michael D. Wilson; Ian C. Scott ABSTRACT A key event in heart development is the timely addition of cardiac progenitor cells, defects in which can lead to congenital heart defects. However, how the balance and proportion of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev162578.
Published: 17 October 2018
... have enabled the development of analytical tools necessary to identify distinct relationships between hemodynamic parameters and the rapidly morphing pharyngeal arch manifold. Aortic arches Chick embryo Computational modeling Heart development Hemodynamics Mechanical forces...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev164194.
Published: 30 July 2018
... preceded by sarcomere disassembly and changes in cell shape and volume, with distinct signaling pathways controlling proliferation of compact and trabecular cardiomyocytes. Heart development Cardiomyocyte proliferation Trabeculation Sarcomere The heart is the first organ to form and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev159210.
Published: 17 May 2018
... heart development reveals its role in compact wall maturation and trabeculation, as well as in modulation of the cardiomyocyte actomyosin network and cell-cell junctions. Heart development Hippo pathway Yap Taz Wwtr1 Trabeculation Cardiac trabeculation is an important step to cardiac...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3487–3498.
Published: 01 October 2017
... heart development, during which many congenital heart disease malformations likely arise, we conducted an RNA-seq timecourse in zebrafish from 30 hpf to 72 hpf and identified 5861 genes with altered expression. We clustered the genes by temporal expression pattern, identified transcription factor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 3866–3870.
Published: 01 November 2016
... Company of Biologists Ltd 2016 Summary: This Meeting Review summarises the findings presented at the 2016 Weinstein Cardiovascular Development Conference, highlighting the range of research currently being applied to study human cardiac diseases. Congenital heart defects Heart development...
Journal Articles
Journal: Development
Development (2016) 143 (14): 2561–2572.
Published: 15 July 2016
... article: Short-term gestational hypoxia in developing mouse embryos induces common types of heart defects by activating the unfolded protein response. FGF signaling Heart development Hypoxia Unfolded protein response Congenital heart disease (CHD) is an abnormality in the structure or...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2135–2146.
Published: 15 June 2016
... studying co-regulation and regulatory landscape organization during heart development and disease. Here, we analyzed the chromatin conformation, epigenetic status and enhancer potential of sequences of the Nppa-Nppb cluster in vivo . Our data indicate that the regulatory landscape of the cluster is present...
Includes: Supplementary data