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Keywords: Heart development
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Journal Articles
Journal: Development
Development (2022) 149 (6): dev200375.
Published: 25 March 2022
... precursor pool. Sustained Wt1 expression in cardiomyocytes can change their cell fate into epicardial-like cells. wt1a wt1b Heart development Cardiomyocyte Epicardium Zebrafish Cell fate Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung http...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev200458.
Published: 18 March 2022
...Ke Zhao; Xinyi Huang; Wukui Zhao; Bin Lu; Zhongzhou Yang ABSTRACT The mitochondrial matrix AAA + Lon protease (LONP1) degrades misfolded or unassembled proteins, which play a pivotal role in mitochondrial quality control. During heart development, a metabolic shift from anaerobic glycolysis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199691.
Published: 22 October 2021
...Christopher J. Derrick; Eric J. G. Pollitt; Ashley Sanchez Sevilla Uruchurtu; Farah Hussein; Andrew J. Grierson; Emily S. Noël ABSTRACT During early vertebrate heart development, the heart transitions from a linear tube to a complex asymmetric structure, a morphogenetic process that occurs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (13): dev199628.
Published: 28 June 2021
.... and Klose , R. J. ( 2015 ). Targeting Polycomb systems to regulate gene expression: modifications to a complex story . Nat. Rev. Mol. Cell Biol. 16 , 643 - 649 . 10.1038/nrm4067 Bruneau , B. G. ( 2013 ). Signaling and transcriptional networks in heart development and regeneration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev199026.
Published: 16 April 2021
...Mingjie Xu; Jie Yao; Yingchao Shi; Huijuan Yi; Wukui Zhao; Xinhua Lin; Zhongzhou Yang ABSTRACT Mammalian heart development relies on cardiomyocyte mitochondrial maturation and metabolism. Embryonic cardiomyocytes make a metabolic shift from anaerobic glycolysis to oxidative metabolism by mid...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev191320.
Published: 5 March 2021
... Extracellular matrix Heart development Heart regeneration Heart development is a highly complex process requiring tight spatiotemporal coordination of multiple chemical and physical signals to shape heart morphology and support cardiac function. Vertebrate heart morphogenesis is initiated during...
Journal Articles
Journal: Development
Development (2020) 147 (21): dev194233.
Published: 21 October 2020
... into the development of the heart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic insights into congenital heart defects. In more recent years, the lessons learned from studying heart development have been applied to interrogating regeneration of the diseased heart...
Journal Articles
Journal: Development
Development (2020) 147 (20): dev188706.
Published: 15 October 2020
... in the cardiac regeneration response to injury. Cardiac neural crest cells Cardiac specification Myocardium Heart development Cardiac regeneration Neural crest cells (NCCs) are a multipotential population of cells unique to vertebrates that arise after delamination from the dorsal-most aspect...
Journal Articles
Journal: Development
Development (2020) 147 (12): dev185900.
Published: 17 June 2020
..., an ancillary Tgfβ receptor, is required for extraembryonic angiogenesis and plays a key role in heart development . Dev. Biol.   217 , 42 - 53 . 10.1006/dbio.1999.9534 Auman , H. J. , Coleman , H. , Riley , H. E. , Olale , F. , Tsai , H.-J. and Yelon , D. ( 2007...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (5): dev185652.
Published: 2 March 2020
...Andrew Holowiecki; Kelsey Linstrum; Padmapriyadarshini Ravisankar; Kashish Chetal; Nathan Salomonis; Joshua S. Waxman ABSTRACT Vertebrate heart development requires the integration of temporally distinct differentiating progenitors. However, few signals are understood that restrict the size...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev174441.
Published: 13 December 2019
... pluripotent stem cells Heart development Regenerative medicine BNC1 Single cell The epicardium is an epithelium covering the heart, which is essential for normal cardiac development. Epicardial cells originate from the pro-epicardial (PE) organ, an outgrowth of non-cardiac, coelomic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev185314.
Published: 9 December 2019
... computationally identified nine murine lincRNAs that have developmentally regulated transcriptional and epigenomic profiles specific to early heart differentiation. Six of the nine lincRNAs had in vivo expression patterns supporting a potential function in heart development, including a transcript downstream...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev176198.
Published: 4 July 2019
... remain challenging. Here, using multiple knockout mouse models and single cell RNA sequencing, we demonstrate that the divergent lncRNA Hand2os1 / Uph has a key complex modulatory effect on the expression of its neighboring gene HAND2 and subsequently on heart development and function. Short deletion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174961.
Published: 4 July 2019
..., plays key roles in heart development and regeneration. During embryogenesis, the epicardium arises from the proepicardium (PE), a cell cluster that appears in the dorsal pericardium (DP) close to the venous pole of the heart. Little is known about how the PE emerges from the pericardial mesothelium...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev170753.
Published: 1 February 2019
...Noelia Muñoz-Martín; Rocío Sierra; Thomas Schimmang; Cristina Villa del Campo; Miguel Torres ABSTRACT Myc is considered an essential transcription factor for heart development, but cardiac defects have only been studied in global Myc loss-of-function models. Here, we eliminated Myc by recombining...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (22): dev167510.
Published: 21 November 2018
...Natalie Gibb; Savo Lazic; Xuefei Yuan; Ashish R. Deshwar; Meaghan Leslie; Michael D. Wilson; Ian C. Scott ABSTRACT A key event in heart development is the timely addition of cardiac progenitor cells, defects in which can lead to congenital heart defects. However, how the balance and proportion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev162578.
Published: 17 October 2018
.... Aortic arches Chick embryo Computational modeling Heart development Hemodynamics Mechanical forces Congenital heart defects (CHDs) constitute the most severe form of a birth defect, accounting for 24% of deaths from developmental abnormalities ( Mozaffarian et al., 2016 ). Abnormal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev164194.
Published: 30 July 2018
... disassembly and changes in cell shape and volume, with distinct signaling pathways controlling proliferation of compact and trabecular cardiomyocytes. Heart development Cardiomyocyte proliferation Trabeculation Sarcomere The heart is the first organ to form and function, and it faces...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev159210.
Published: 17 May 2018
... the molecular and cellular mechanisms of heart development using the zebrafish . Annu. Rev. Genet.   46 , 397 - 418 . 10.1146/annurev-genet-110711-155646 Staudt , D. W. , Liu , J. , Thorn , K. S. , Stuurman , N. , Liebling , M. and Stainier , D. Y. R. ( 2014 ). High...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3487–3498.
Published: 1 October 2017
... of heart development, during which many congenital heart disease malformations likely arise, we conducted an RNA-seq timecourse in zebrafish from 30 hpf to 72 hpf and identified 5861 genes with altered expression. We clustered the genes by temporal expression pattern, identified transcription factor...
Includes: Supplementary data