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Keywords: Heart
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Journal Articles
Journal: Development
Development (2021) 148 (17): dev199307.
Published: 31 August 2021
...) pathway lead to severe brain malformations with variable penetrance due to unknown modifier genes. To identify such modifiers, we established novel congenic mouse models. LRP2-deficient C57BL/6N mice suffer from heart outflow tract defects and holoprosencephaly caused by impaired SHH activity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (16): dev199672.
Published: 23 August 2021
... of new therapies is lagging compared with other fields. One major bottleneck hindering progress is the lack of self-organizing human cardiac models that recapitulate key aspects of human heart development, physiology and disease. Current in vitro cardiac three-dimensional systems are either engineered...
Journal Articles
Journal: Development
Development (2020) 147 (24): dev194019.
Published: 23 December 2020
...Ian J. Begeman; Kwangdeok Shin; Daniel Osorio-Méndez; Andrew Kurth; Nutishia Lee; Trevor J. Chamberlain; Francisco J. Pelegri; Junsu Kang ABSTRACT Heart regeneration in regeneration-competent organisms can be accomplished through the remodeling of gene expression in response to cardiac injury...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev186569.
Published: 27 April 2020
... and differential state of multiple cell types, during both development and adulthood. Here, we report how Runx1 is specifically upregulated at the injury site during zebrafish heart regeneration, and that absence of runx1 results in increased myocardial survival and proliferation, and overall heart regeneration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (6): dev180844.
Published: 19 March 2020
... , 20609 - 20614 . 10.1073/pnas.1118017108 Liao , S. , Dong , W. , Lv , L. , Guo , H. , Yang , J. , Zhao , H. , Huang , R. , Yuan , Z. , Chen , Y. , Feng , S. , et al. ( 2017 ). Heart regeneration in adult Xenopus tropicalis after apical resection . Cell...
Journal Articles
Journal: Development
Development (2019) 146 (14): dev177121.
Published: 29 July 2019
.../ Highlighted Article: Monitor lizards, which have the most-pronounced ventricular septation of lizards, express evolutionarily conserved transcription factors and exhibit a specialized manner of electrical activation. Heart Ventricular septum Evolution Lizard The evolution of land-living...
Journal Articles
Journal: Development
Development (2019) 146 (19): dev174086.
Published: 05 July 2019
..., and BAF170 loss leads to retention of BRG1 at CP-specific sites. Thus, dynamic interdependent BAF complex subunit assembly modulates chromatin states and thereby participates in directing temporal gene expression programs in cardiogenesis. To model early heart development, we differentiated mouse embryonic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174482.
Published: 02 July 2019
...Vanessa Lowe; Laura Wisniewski; Jacob Sayers; Ian Evans; Paul Frankel; Nadia Mercader-Huber; Ian C. Zachary; Caroline Pellet-Many ABSTRACT Unlike adult mammals, zebrafish can regenerate their heart. A key mechanism for regeneration is the activation of the epicardium, leading to the establishment...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev172957.
Published: 20 February 2019
...Julie L. M. Moreau; Scott Kesteven; Ella M. M. A. Martin; Kin S. Lau; Michelle X. Yam; Victoria C. O'Reilly; Gonzalo del Monte-Nieto; Antonio Baldini; Michael P. Feneley; Anne M. Moon; Richard P. Harvey; Duncan B. Sparrow; Gavin Chapman; Sally L. Dunwoodie ABSTRACT Congenital heart disease (CHD...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev158717.
Published: 17 January 2018
...Monika Zmojdzian; Svetlana de Joussineau; Jean Philippe Da Ponte; Krzysztof Jagla ABSTRACT The Drosophila heart, composed of discrete subsets of cardioblasts and pericardial cells, undergoes Hox-triggered anterior-posterior morphogenesis, leading to a functional subdivision into heart proper...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (5): 866–875.
Published: 01 March 2017
...Jun-yi Zhu; Amy Heidersbach; Irfan S. Kathiriya; Bayardo I. Garay; Kathryn N. Ivey; Deepak Srivastava; Zhe Han; Isabelle N. King miR-1 is a small noncoding RNA molecule that modulates gene expression in heart and skeletal muscle. Loss of Drosophila miR-1 produces defects in somatic muscle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (2): 334–344.
Published: 15 January 2017
...Ayano Chiba; Haruko Watanabe-Takano; Kenta Terai; Hajime Fukui; Takahiro Miyazaki; Mami Uemura; Hisashi Hashimoto; Masahiko Hibi; Shigetomo Fukuhara; Naoki Mochizuki ABSTRACT The heart is an endocrine organ, as cardiomyocytes (CMs) secrete natriuretic peptide (NP) hormones. Since the discovery...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (9): 1435–1441.
Published: 01 May 2016
...’. As I review here, participants at the workshop revealed how understanding cardiac growth and lineage decisions at their most fundamental level has transformed the strategies in hand that presently energize the prospects for human heart repair. I am grateful to Brian Black and James Martin...
Journal Articles
Journal: Development
Development (2016) 143 (3): 387–397.
Published: 01 February 2016
... to replace the scar and rebuild normal functioning tissue. Here, we address this problem in the context of heart disease, and discuss the origins and characteristics of cardiac fibroblasts, as well as the crucial role that they play in cardiac development and disease. We discuss the dual nature of cardiac...
Journal Articles
Journal: Development
Development (2016) 143 (3): 473–482.
Published: 01 February 2016
...Michael G. Monaghan; Miriam Linneweh; Simone Liebscher; Ben Van Handel; Shannon L. Layland; Katja Schenke-Layland The elucidation of mechanisms in semilunar valve development might enable the development of new therapies for congenital heart disorders. Here, we found differences in proliferation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (1): 113–122.
Published: 01 January 2016
...Leila Jahangiri; Michka Sharpe; Natasha Novikov; Juan Manuel González-Rosa; Asya Borikova; Kathleen Nevis; Noelle Paffett-Lugassy; Long Zhao; Meghan Adams; Burcu Guner-Ataman; Caroline E. Burns; C. Geoffrey Burns The vertebrate heart forms through successive phases of cardiomyocyte differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (21): 3630–3636.
Published: 01 November 2015
...Catherine A. Risebro; Joaquim Miguel Vieira; Linda Klotz; Paul R. Riley The epicardium is essential for mammalian heart development. At present, our understanding of the timing and morphogenetic events leading to the formation of the human epicardium has essentially been extrapolated from model...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (20): 3456–3467.
Published: 15 October 2015
... is supported in part by the National Institute of Neurological Disorders and Stroke at the National Institutes of Health [R00NS083714 to F.E.P.]. Work in the H.J.Y. laboratory is supported by the National Heart, Lung, and Blood Institute at the National Institutes of Health. Deposited in PMC for release after...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (14): 2452–2463.
Published: 15 July 2015
... examined, including T-cell development, skin differentiation and carcinogenesis, the inner ear, the lung and the retina. We were able to show that phenotypes in the heart, endothelium, and marginal zone B cells are attributed to haploinsufficiency but not to intracellular domain composition. Tissue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (13): 2304–2315.
Published: 01 July 2015
... differentiation. * Present address: Department of Medicine, Division of Cardiology, University of California, San Diego, La Jolla, CA 92093, USA. ‡ Present address: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, Bad Nauheim 61231, Germany...
Includes: Supplementary data