1-3 of 3
Keywords: Hearing loss
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Cellular diversity of human inner ear organoids revealed by single-cell transcriptomics

Mireia Rumbo, Berta Alsina
Journal: Development
Development (2024) 151 (23): dev202524.
https://doi.org/10.1242/dev.202524
Published: 29 November 2024
... development, mutations causing hearing loss and vertigo, and new therapeutic drugs. However, the extent to which such organoids mimic in vivo human inner ear development and cellular composition remains unclear. Several recent studies have performed single-cell transcriptomics on human inner ear organoids...
View articletitled, Cellular diversity of human inner ear organoids revealed by single-cell transcriptomics
Open the PDF for Cellular diversity of human inner ear organoids revealed by single-cell transcriptomics in another window
Journal Articles

Epithelial dynamics shed light on the mechanisms underlying ear canal defects

Juan M. Fons, Mona Mozaffari, Dean Malik, Abigail R. Marshall, Steve Connor, Nicholas D. E. Greene, Abigail S. Tucker
Journal: Development
Development (2020) 147 (23): dev194654.
https://doi.org/10.1242/dev.194654
Published: 14 December 2020
...Juan M. Fons; Mona Mozaffari; Dean Malik; Abigail R. Marshall; Steve Connor; Nicholas D. E. Greene; Abigail S. Tucker ABSTRACT Defects in ear canal development can cause severe hearing loss as sound waves fail to reach the middle ear. Here, we reveal new mechanisms that control human canal...
View articletitled, Epithelial dynamics shed light on the mechanisms underlying ear canal defects
Open the PDF for Epithelial dynamics shed light on the mechanisms underlying ear canal defects in another window
Includes: Supplementary data
Journal Articles

Lack of Bdnf and TrkB signalling in the postnatal cochlea leads to a spatial reshaping of innervation along the tonotopic axis and hearing loss

Thomas Schimmang, Justin Tan, Marcus Müller, Ulrike Zimmermann, Karin Rohbock, Iris Köpschall, Annette Limberger, Liliana Minichiello, Marlies Knipper
Journal: Development
Development (2003) 130 (19): 4741–4750.
https://doi.org/10.1242/dev.00676
Published: 1 October 2003
... of nerve fibres at the base in adult mutants. Measurements of auditory brain stem responses of these mice revealed a significant hearing loss. The observed innervation patterns correlate with opposing gradients of Bdnf and Nt3 expression in cochlear neurones along the tonotopic axis. Thus, the reshaping...
View articletitled, Lack of Bdnf and TrkB signalling in the postnatal cochlea leads to a spatial reshaping of innervation along the tonotopic axis and hearing loss
Open the PDF for Lack of Bdnf and TrkB signalling in the postnatal cochlea leads to a spatial reshaping of innervation along the tonotopic axis and hearing loss in another window