... response thresholds, suggesting that this gene is essential for hearing development. ‡ These authors contributed equally to this work * Present address: Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA. § Author for correspondence ( [email protected]...

... in cell morphology in the auditory sensory epithelium. This study reveals a fundamental mechanism regulating cell morphology and frequency-place coding in the developing cochlea. Metabolism Mitofusin Biogenesis Hearing Chick Biotechnology and Biological Sciences Research Council http...

... Slc26a9 as an otic placode-specific target of the FGFR2b ligands FGF3 and FGF10. We show here that Slc26a9 is otic specific through E10.5, but is not required for hearing. We targeted P2ACre to the Slc26a9 stop codon, generating Slc26a9 P2ACre mice, and observed CRE activity throughout the otic epithelium...

... of cochlear formation including cell fate, outgrowth and patterning. Atoh1 Deafness Hearing Notch Organ of Corti Radial intercalation The mammalian inner ear is a remarkable structure, made up of a labyrinth of elaborate ducts and canals ( Fig. 1 ). Together, these facilitate the perception...

...Anshula Samarajeewa; Danielle R. Lenz; Lihong Xie; Hao Chiang; Rory Kirchner; Joanna F. Mulvaney; Albert S. B. Edge; Alain Dabdoub ABSTRACT Lack of sensory hair cell (HC) regeneration in mammalian adults is a major contributor to hearing loss. In contrast, the neonatal mouse cochlea retains...

... radially with an apically directed slant – a feature considered crucial for hearing. To determine how this pattern is generated, collagen-fibril formation was examined in mice lacking a tectorin-based matrix, epithelial cilia or the planar cell polarity genes Vangl2 and Ptk7 . In wild-type mice, collagen...

... epibranchial progenitors. By recapitulating the embryonic programme, the genes and genetic sub-circuits discovered here might be useful for reprogramming naïve cells towards otic identity to restore hearing loss. * These authors contributed equally to this work ‡ These authors contributed equally...

... SGN. We have characterized the spatiotemporal reorganization of the dual afferent innervation pattern as it is established in the developing mouse cochlea. This reorganization occurs during the first postnatal week just before the onset of hearing. Our data reveal three distinct phases...

... shaker-1 Mouse mutant Myosin VIIA Cochlea Hair cell Stereocilia Hearing Usher syndrome Very little is known about the molecular basis of sensory hair cell function or development, partly because the small number of hair cells in each inner ear makes a biochemical approach impractical. We...

... 1996 © 1996 by Company of Biologists 1996 inner ear otic vesicle otolith semicircular canal mechanosensory hair cell lateral line hearing balance zebrafish Danio rerio mutant The vertebrate inner ear is an intricate and self-contained model system for developmental...

... of Virginia Hearing Foundation. REFERENCES Anniko , M. ( 1983 ). Cytodifferentiation of cochlear hair cells . Am. J. Otolaryngol . 4 , 375 – 388 . 10.1016/S0196-0709(83)80043-X Bailey , J. S. and Siu , C.-H. ( 1988 ). Purification and partial characterization of a novel...