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Keywords: Hdac
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Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (10): dev173112.
Published: 22 May 2019
... that the evolutionarily conserved BarH-like homeobox-2 (Barhl2) protein stabilizes the Tcf7l1-Gro complex and maintains the repressed expression of Tcf target genes by a mechanism that depends on histone deacetylase 1 (Hdac-1) activity. In this way, Barhl2 switches off the Wnt/β-Catenin-dependent early transcriptional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev163386.
Published: 8 August 2018
... to preserve their developmental potential remain poorly understood. Here, we explore the role of histone deacetylase (HDAC) activity in this process in Xenopus . We show that HDAC activity is essential for the formation of neural crest, as well as for proper patterning of the early ectoderm. The requirement...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (4): 761–772.
Published: 15 February 2014
... cell Epigenetic control CoREST Hdac Mouse Midbrain dopamine (mDA) neurons play important roles in voluntary movement, emotion and reward-based behaviors. Dysfunction or degeneration of this neuronal subtype is related to major neuropsychiatric disorders such as Parkinson’s disease...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (9): 1912–1918.
Published: 1 May 2013
.... 22 2 2013 © 2013. Published by The Company of Biologists Ltd 2013 Ssrp1 Cell cycle Hdac Liver Organogenesis Zebrafish Drosophila Expansion of progenitor pools and their tissue-specific differentiation are central for the formation of functional organs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (15): 3393–3403.
Published: 1 August 2005
... to this differentiation process. As histone deacetylase(HDAC) activity has been linked to HIF-dependent gene expression, we investigated whether ARNT deficiency affects this epigenetic regulator. Interestingly, Arnt -null TS cells had reduced HDAC activity,increased global histone acetylation, and altered class II HDAC...