... the number of Olig2 + motoneuron progenitors and Hb9 + motoneurons without a significant effect on cell survival or proliferation. These effects were a specific and direct consequence of Shh reduction in the mesoderm. In addition, grafting notochords in a basal but not apical location, vis-à-vis the tube...

... progenitor cells. In addition, we show an important influence of the immune system on motor neuron regeneration from these progenitor cells. To assess whether newly generated motor neurons in larvae were derived from the olig2 -expressing cells, we used EdU labelling in Hb9 :GFP; olig2 :DsRed double...

... postembryonic neuronal lineages and 29 of the 34 major neuronal hemilineages. Pilot functional studies reveal that the identified transcription factors direct the development and differentiation of the postembryonic neurons expressing them. We previously determined that Hb9 (also known as Extra-extra...

... the zebrafish to uncover genes that function downstream of RA signaling, and here we identify mnx1 ( hb9 ) as an RA-regulated endoderm transcription factor-encoding gene. By combining manipulation of gene function, cell transplantation approaches and transgenic reporter analysis we establish that Mnx1 functions...

... and show that the single Drosophila ortholog of Dbx1/2 contributes to the development of specific subsets of interneurons via cross-repressive, lineage-specific interactions with the motoneuron-promoting factors eve and hb9 ( exex ). dbx is expressed primarily in interneurons of the embryonic, larval...

... © 2004. 2004 nkx6.1 Danio rerio Drosophila melanogaster Hedgehog Primary motoneurons Secondary motoneurons Interneurons Eve HB9 Islet The growing number of genes expressed in similar patterns during axis formation and early central nervous system (CNS) patterning...

...Soo-Kyung Lee; Linda W. Jurata; Junichi Funahashi; Esmeralda C. Ruiz; Samuel L. Pfaff The underlying transcriptional mechanisms that establish the proper spatial and temporal pattern of gene expression required for specifying neuronal fate are poorly defined. We have characterized how the Hb9 gene...

... and the Engrailed repressor domain. Consistent with the apparent sufficiency of repressor function, a fusion protein between the Gal4 DNA-binding domain and Eve repressor domains was capable of actively repressing UAS target genes in these neurons. A key target of the repressor function of Eve was Drosophila Hb9...