...Zhe Han; Peng Yi; Xiumin Li; Eric N. Olson The Hand gene family encodes highly conserved basic helix-loop-helix (bHLH)transcription factors that play crucial roles in cardiac and vascular development in vertebrates. In Drosophila , a single Hand gene is expressed in the three major cell types...

... remain unknown. Here, we show that the highly conserved basic helix-loop-helix (bHLH)transcription factor Hand is expressed in cardioblasts, pericardial nephrocytes and hematopoietic progenitors. The homeodomain protein Tinman and the GATA factors Pannier and Serpent directly activate Hand in these cell...

...Laura D. Mathies; Samuel T. Henderson; Judith Kimble The C. elegans genome encodes a single Hand bHLH transcription factor. Either hnd-1(RNAi) or a hnd-1 deletion causes partially penetrant defects in viability and gonadogenesis. Dead embryos and young larvae are often misshapen at the posterior...