... of their targets. Supporting this model, elimination of the Groucho interaction domain in Bowl prevents the activation of the Notch and Hedgehog pathways, although not the repression of the Wingless pathway. Similarly, the effects of ectopic Bowl are partially rescued by co-expression of either Hairless or Master...

..., Su(H) acts as a repressor. We also find that the Hairless protein interacts with Notch signalling during wing development and inhibits the activity of Su(H). Our results suggest that, in Drosophila , the activation of Su(H) by Notch involve the release of Su(H) from an inhibitory complex, which...

...François Schweisguth; James W. Posakony ABSTRACT Successive alternative cell fate choices in the imaginal disc epithelium lead to the differentiation of a relatively invariant pattern of multicellular adult sensory organs in Drosophila . We show here that the activity of Suppressor of Hairless...

...Anne G. Bang; Volker Hartenstein; James W. Posakony ABSTRACT Reduction of the wild-type activity of the gene Hairless (H) results in two major phenotypic effects on the mechanosensory bristles of adult Drosophila . Bristles are either ‘lost’ (i.e. the shaft and socket fail to appear...