...Otto J. M. Mäkelä; Marja L. Mikkola ABSTRACT Tissue interactions are essential for guiding organ development and regeneration. Hair follicle formation relies on inductive signalling between two tissues, the embryonic surface epithelium and the adjacent mesenchyme. Although previous research has...

...Maureen Cetera; Rishabh Sharan; Gabriela Hayward-Lara; Brooke Phillips; Abhishek Biswas; Madalene Halley; Evalyn Beall; Bridgett vonHoldt; Danelle Devenport ABSTRACT The planar cell polarity (PCP) pathway collectively orients cells with respect to a body axis. Hair follicles of the murine epidermis...

...Bo Dong; Samantha Vold; Cristina Olvera-Jaramillo; Hao Chang ABSTRACT The orientation of mouse hair follicles is controlled by the planar cell polarity (PCP) pathway. Mutations in PCP genes result in two categories of hair mis-orientation phenotype: randomly oriented and vertically oriented...

... of Biologists Ltd 2017 Summary: This Review presents current knowledge of the development of the sensory microdomains in mammalian skin and the mechanosensory neurons that innervate them. Touch Skin Hair follicle Merkel cell Placode Axon guidance Like all senses, the sense of touch...

...Rehan Villani; Samantha Hodgson; Julien Legrand; Jessica Greaney; Ho Yi Wong; Cathy Pichol-Thievend; Christelle Adolphe; Brandon Wainwight; Mathias Francois; Kiarash Khosrotehrani SOX family proteins SOX2 and SOX18 have been reported as being essential in determining hair follicle type; however...

... tongue epithelia. Surprisingly, however, in dorsal tongue LGN is predominantly localized basally, circumferentially or bilaterally and promotes planar divisions. Loss of LGN disrupts the organization and morphogenesis of filiform papillae but appears to be dispensable for embryonic hair follicle...

...Philip Tomann; Ralf Paus; Sarah E. Millar; Claus Scheidereit; Ruth Schmidt-Ullrich ABSTRACT In the epidermis of mice lacking transcription factor nuclear factor-kappa B (NF-κB) activity, primary hair follicle (HF) pre-placode formation is initiated without progression to proper placodes. NF-κB...

...Ning Yang; Li Li; Thibaut Eguether; John P. Sundberg; Gregory J. Pazour; Jiang Chen Hair follicle morphogenesis requires precisely controlled reciprocal communications, including hedgehog (Hh) signaling. Activation of the Hh signaling pathway relies on the primary cilium. Disrupting ciliogenesis...

...Zhong L. Hua; Hao Chang; Yanshu Wang; Philip M. Smallwood; Jeremy Nathans In mammals, a set of anatomically diverse polarity processes – including axon growth and guidance, hair follicle orientation, and stereociliary bundle orientation in inner ear sensory hair cells – appear to be mechanistically...

... by The Company of Biologists Ltd 2014 Exocrine gland Skin appendage Hair follicle Ectodermal dysplasia Heatstroke Hyperhidrosis Mouse The functions of the skin, the largest human organ, are expanded by various appendages. Skin exocrine glands are secretory appendages that include sweat...

...Natalia A. Veniaminova; Alicia N. Vagnozzi; Daniel Kopinke; Thy Thy Do; L. Charles Murtaugh; Ivan Maillard; Andrzej A. Dlugosz; Jeremy F. Reiter; Sunny Y. Wong The formation of epithelial tubes underlies the development of diverse organs. In the skin, hair follicles resemble tube-like structures...

...Erin Leishman; Jeffrey M. Howard; Gloria E. Garcia; Qi Miao; Amy T. Ku; Joseph D. Dekker; Haley Tucker; Hoang Nguyen Hair follicles cyclically degenerate and regenerate throughout adult life and require regular stem cell activation to drive the cycle. In the resting phase of the hair cycle, hair...

...Inês Sequeira; Jean-François Nicolas The hair follicle (HF) is a multi-tissue mini-organ that self-renews periodically. However, the cellular organisation of this much-studied model is not fully understood. The structures of the outer layer and of the bulb, which ensures HF growth, have not been...

...Monica Teta; Yeon Sook Choi; Tishina Okegbe; Gabrielle Wong; Oliver H. Tam; Mark M. W. Chong; John T. Seykora; Andras Nagy; Dan R. Littman; Thomas Andl; Sarah E. Millar MicroRNAs (miRNAs) regulate the expression of many mammalian genes and play key roles in embryonic hair follicle development...

...Demeng Chen; Andrew Jarrell; Canting Guo; Richard Lang; Radhika Atit Dermal fibroblasts are required for structural integrity of the skin and for hair follicle development. Uniform Wnt signaling activity is present in dermal fibroblast precursors preceding hair follicle initiation...

... along the hair follicle (D). Panels C and D represent the same field of view. SG, sebaceous gland. ( E ) Percentage of hair follicles (HFs) exhibiting intact tIISCs in skin from mice treated five times with CGP 39551. Error bars represent s.d. (three mice per treatment group). n , number of hair...

... its established role as a transcriptional repressor. Our findings identify Trps1 as a novel regulator of the Wnt signaling pathway and of early hair follicle progenitors in the developing vibrissa follicle. * Author for correspondence ( [email protected] ) Competing interests statement...

...Mandy J. Croyle; Jonathan M. Lehman; Amber K. O'Connor; Sunny Y. Wong; Erik B. Malarkey; Daniela Iribarne; William E. Dowdle; Trenton R. Schoeb; Zoe M. Verney; Mohammad Athar; Edward J. Michaud; Jeremy F. Reiter; Bradley K. Yoder Skin and hair follicle morphogenesis and homeostasis require...

...Rose-Anne Romano; Kirsten Smalley; Song Liu; Satrajit Sinha The transcription factor p63 plays an essential role in epidermal morphogenesis. Animals lacking p63 fail to form many ectodermal organs, including the skin and hair follicles. Although the indispensable role of p63 in stratified...

...Emilie Legué; Inês Sequeira; Jean-François Nicolas The hair follicle (HF) grows during the anagen phase from precursors in the matrix that give rise to each differentiated HF layer. Little is known about the lineal relationship between these layer-restricted precursors and HF stem cells...