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Keywords: Hair cells
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Journal Articles
Journal: Development
Development (2023) 150 (19): dev201865.
Published: 5 October 2023
... and it happens over the course of a few weeks in humans. HC in the vestibular organs develop before HC in the cochlea (∼2 weeks). Cells at the base of the cochlea develop before cells in the apical turn, and inner hair cells (IHC) differentiate before OHC. The whole process spans between weeks 8 and 13 ( Locher...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2023) 150 (12): dev201071.
Published: 29 June 2023
...Yoshitomo Ueda; Takashi Nakamura; Jing Nie; Alexander J. Solivais; John R. Hoffman; Becca J. Daye; Eri Hashino ABSTRACT The inner ear sensory epithelia contain mechanosensitive hair cells and supporting cells. Both cell types arise from SOX2-expressing prosensory cells, but the mechanisms...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (5): dev196899.
Published: 9 March 2021
... F0 mice; these mice not only survived longer than regular Atoh1 / Sox10 knockout mice but also displayed their recognized cochlear phenotypes. Moreover, by using mosaic CRISPR-stop, we uncovered a previously unknown role of another lethal gene, Rbm24 , in the survival of cochlear outer hair cells...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (17): dev177188.
Published: 2 September 2019
... . Recent advances in the field of stem cell biology and organoid culture systems allow the expansion and differentiation of tissue-specific progenitors and pluripotent stem cells in vitro into functional hair cells and otic-like neurons. We discuss how inner ear organoids have been developed and how...
Journal Articles
Journal: Development
Development (2016) 143 (21): 4003–4015.
Published: 1 November 2016
..., or specific hair cells within them, is unclear. To address how the precise timing of Wnt signaling impacts patterning across the radial axis, mouse cochlear cultures were initiated at embryonic day 12.5 and subjected to pharmacological treatments at different stages. Early changes in major patterning genes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 4003–4015.
Published: 1 November 2016
..., or specific hair cells within them, is unclear. To address how the precise timing of Wnt signaling impacts patterning across the radial axis, mouse cochlear cultures were initiated at embryonic day 12.5 and subjected to pharmacological treatments at different stages. Early changes in major patterning genes...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (11): 2313–2324.
Published: 1 June 2014
... in hair cell determination. These mechanisms depend respectively on two different ligands, jagged 1 (Jag1) and delta 1 (Dl1), that rely on a common signaling cascade initiated after Notch activation. In the chicken otocyst, expression of Jag1 and the Notch target Hey1 correlates well with lateral...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (6): 1196–1206.
Published: 15 March 2013
...Taha Adnan Jan; Renjie Chai; Zahra Nabi Sayyid; Renée van Amerongen; Anping Xia; Tian Wang; Saku Tapani Sinkkonen; Yi Arial Zeng; Jared Ruben Levin; Stefan Heller; Roel Nusse; Alan Gi-Lun Cheng Permanent hearing loss is caused by the irreversible damage of cochlear sensory hair cells and nonsensory...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (23): 4395–4404.
Published: 1 December 2012
.... In the inner ear, this pathway has been shown to regulate the size of the otic placode from which the cochlea will arise; however, direct activity of canonical Wnt signaling as well as its function during cochlear mechanosensory hair cell development had yet to be identified. Using TCF/Lef:H2B-GFP reporter...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2011) 138 (6): 1143–1152.
Published: 15 March 2011
...Indra Wibowo; Filipe Pinto-Teixeira; Chie Satou; Shin-ichi Higashijima; Hernán López-Schier Bilateral symmetric tissues must interpret axial references to maintain their global architecture during growth or repair. The regeneration of hair cells in the zebrafish lateral line, for example, forms...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2008) 135 (20): 3425–3434.
Published: 15 October 2008
... with dilated cardiomyopathy, we studied eya4 expression during zebrafish development and characterized eya4 deficiency. eya4 morphant fish embryos had reduced numbers of hair cells in the otic vesicle and lateral line neuromasts with impaired sensory responses. Analyses of candidate genes that are known...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2007) 134 (2): 295–305.
Published: 15 January 2007
...Bonny B. Millimaki; Elly M. Sweet; Mary S. Dhason; Bruce B. Riley Hair cells of the inner ear develop from an equivalence group marked by expression of the proneural gene Atoh1 . In mouse, Atoh1 is necessary for hair cell differentiation, but its role in specifying the equivalence group (proneural...