...Woo Chi; Eleanor Wu; Bruce A. Morgan Although the hair shaft is derived from the progeny of keratinocyte stem cells in the follicular epithelium, the growth and differentiation of follicular keratinocytes is guided by a specialized mesenchymal population, the dermal papilla (DP), that is embedded...

...Katja Närhi; Elina Järvinen; Walter Birchmeier; Makoto M. Taketo; Marja L. Mikkola; Irma Thesleff During embryonic and postnatal development, Wnt/β-catenin signaling is involved in several stages of hair morphogenesis from placode formation to hair shaft differentiation. Using a transgenic...

...Ramanuj DasGupta; Elaine Fuchs LEF/TCF DNA-binding proteins act in concert with activated β-catenin, the product of Wnt signaling, to transactivate downstream target genes. To probe the role of activated LEF/TCF transcription factor complexes in hair follicle morphogenesis and differentiation, we...

... ; Chen et al., 1997). For an appendage to form an elongated P-D axis, it needs a growth zone that can generate new cells continuously, whether new cells are added distally such as found in the progress zone of the limb bud, or proximally such as in the collar of the feather follicle (equivalent to hair...

...Linda Karlsson; Cecilia Bondjers; Christer Betsholtz ABSTRACT Skin appendages, such as hair, develop as a result of complex reciprocal signaling between epithelial and mesenchymal cells. These interactions are not well understood at the molecular level. Platelet-derived growth factor-A (PDGF...

...Boris Risek; F. George Klier; Norton B. Gilula ABSTRACT The expression of four different gap junction gene products ( α 1 , β 1 , β 2 , andβ 3) has been analysed during rat skin development and the hair growth cycle. Both α 1 (C×43) and β 2 (C×26) connexins were coexpressed in the undifferentiated...

...P. Pisansarakit; G. P. M. Moore ABSTRACT Rat vibrissa dermal papillae were transplanted between the epidermis and dermis of isolated embryonic mouse skin and then grafted onto nude mice. The papillae induced the formation of hair follicles which were larger than those of the host skin but smaller...