... detected in embryos from ACKR3-blocker-treated mothers. Mice born to mothers treated with the blocker are lighter and shorter than those born to vehicle-treated mothers and, in addition, display profound anaemia associated with a markedly reduced bone marrow haematopoietic stem cell population. Importantly...

... cells. Based on the change in subcellullar localisation of Eto-2 we postulate that it plays a central role in the transition from the migration and expansion phase of the prehaematopoietic cells to the establishment of definitive haematopoietic stem cells. * Author for correspondence (e...

...Parasakthy Kumaravelu; Lilian Hook; Aline M. Morrison; Jan Ure; Suling Zhao; Sergei Zuyev; John Ansell; Alexander Medvinsky In the developing mouse embryo the first definitive(transplantable-into-the-adult) haematopoietic stem cells/long-term repopulating units (HSC/RUs) emerge in the AGM region...

... for establishing the transcriptional programme responsible for the formation of haematopoietic stem cells and have focused attention on the transcriptional regulation of Scl itself. Previous studies have identified a panel of Scl enhancers each of which directed expression to a subdomain of the normal Scl...

...M. Jorge Guimarães; J. Fernando Bazan; Albert Zlotnik; Michael V. Wiles; J. Christopher Grimaldi; Frank Lee; Terrill McClanahan ABSTRACT To understand the mechanisms that control the differentiation of uncommitted mesoderm precursors into haematopoietic stem cells (HSCs) and the activation...