... or inactivation of the epidermal growth factor receptor (EGFR) pathway. Thus, Ppn is critical in maintaining lymph gland architecture and regulating haemocyte differentiation, highlighting an intricate interaction between ECMs and signalling pathways in haematopoiesis. Authors for correspondence...

... genetic networks formed by the transcriptional regulators Zeb2a, Id2a and Batf3. Dendritic cells Haematopoiesis Microglia Zebrafish Central nervous system Shenzhen Bay Laboratory S201101002 National Key Research and Development Program of China 2018YFA0800200...

... waves of blood and endothelial development and interpret state-fate transplantation experiments. Cell fate and differentiation Haematopoiesis Mouse development Single-cell transcriptomics Wellcome http://dx.doi.org/10.13039/100010269 220379/B/20/Z PFZH/158 RG92770 203942/Z/16/Z...

... pluripotent stem cells. By identifying stage-specific changes in molecular signalling during HSC development, this resource could aid in the development of more precise in vitro models for studying human haematopoiesis. In the human embryo, the first definitive HSCs, which become transplantable, emerge...

.... HSC Haematopoiesis Stem cells National Centre for the Replacement, Refinement and Reduction of Animals in Research http://dx.doi.org/10.13039/501100000849 NC/V001922/1 Vetenskapsrådet http://dx.doi.org/10.13039/501100004359 2021-00185 Cancer Research Uk http...

... Transcription factors (TFs) act within wider regulatory networks to control cell identity and fate. Numerous TFs, including Scl (Tal1) and PU.1 (Spi1), are known regulators of developmental and adult haematopoiesis, but how they act within wider TF networks is still poorly understood. Transcription activator...

... unknown. Under defined conditions, embryonic stem (ES) cells can be differentiated into haemangioblast-like progenitors that faithfully recapitulate early embryonic haematopoiesis. Here, we made use of mouse ES cells as a model system to understand the role of SOX7, a member of a large family...

... factor Lmo4. MO-mediated knockdowns in zebrafish show these factors to be essential for definitive haematopoiesis. In accordance with the zebrafish results these factors are coexpressed in prehaematopoietic cells of the early mouse embryo,although we originally identified the complex in late erythroid...

... of FLK1 + cells at these later time points (data not shown). These data confirmed that the absence of Mixl1 impaired haematopoiesis in differentiating ES cells. In order to further explore the relationship between Mixl1 expression and haematopoietic differentiation, the blast colony-forming...

...-of-function studies have shown that Lmo2 and Scl/Tal1 are essential for haematopoiesis and angiogenic remodelling of the vasculature, gain-of-function studies have suggested an earlier role for Scl/Tal1 in the specification of haemangioblasts, putative bipotential precursors of blood and endothelium...

.... Bieker (EKLF); H. Stuhlmann (VEZF) and J. Rossant (VEGFR1 and VEGFR2). ¶Author for correspondence (e-mail: [email protected] ) 28 1 2002 © 2002. 2002 VEGFA Vasculogenesis Haematopoiesis Visceral Endoderm Mouse It has been demonstrated that VEGFA plays an important...

.... It directed lacZ expression in transgenic mice to extra-embryonic mesoderm and subsequently to both endothelial cells and to a subset of blood cells at multiple sites of embryonic haematopoiesis including the yolk sac, para-aortic splanchnopleura and AGM region. The 3’ enhancer also targeted expression...

... of haematopoiesis, we conducted a study to identify genes expressed at the earliest stages of both in vivo and in vitro haematopoietic development. Our strategy was to utilize Differential Display by means of the Polymerase Chain Reaction (DD-PCR) to compare patterns of gene expression between mRNA populations...

...Marion C. Dickson; Julie S. Martin; Frances M. Cousins; Ashok B. Kulkarni; Stefan Karlsson; Rosemary J. Akhurst ABSTRACT Transforming growth factor β1 (TGFβ1) is shown here to be required for yolk sac haematopoiesis and endothelial differentiation. Mice with a targeted mutation in the TGFβ1 gene...

...Maggie E. Walmsley; Matthew J. Guille; David Bertwistle; James C. Smith; John A. Pizzey; Roger K. Patient ABSTRACT To increase our understanding of haematopoiesis during early vertebrate development, we have studied the expression pattern of the transcription factor GATA-2 in Xenopus embryos...

.... , Patek , C. E. , Hardy , K. , Handyside , A. H. , Jones , K. W. , Muggleton-Harris , A. L. , Taylor , A. H. and Hooper , M.L. ( 1991 ). Hypoxanthine phosphoribosyltransferase deficiency, haematopoiesis and fertility in the mouse . Development 112 , 489 – 498 . 10.1242...

... consequences of HPRT-deficiency in humans. HPRT-deficient humans show abnormalities in haematopoiesis and, in heterozygotes, there is strong selection in haematopoietic tissues against HPRT-deficient cells arising as a result of X-chromosome inactivation. We have examined two situations in mice in which HPRT...