...Fiona M. Bain; James L. C. Che; Maria Jassinskaja; David G. Kent ABSTRACT Haematopoietic stem cell (HSC) self-renewal is a process that is essential for the development and homeostasis of the blood system. Self-renewal expansion divisions, which create two daughter HSCs from a single parent HSC...

...Andrejs Ivanovs; Stanislav Rybtsov; Elizabeth S. Ng; Edouard G. Stanley; Andrew G. Elefanty; Alexander Medvinsky Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult haematopoietic system. Understanding how early haematopoietic development occurs is of fundamental...

...Mihaela Crisan; Elaine Dzierzak Not all hematopoietic stem cells (HSCs) are alike. They differ in their physical characteristics such as cell cycle status and cell surface marker phenotype, they respond to different extrinsic signals, and they have different lineage outputs following...

...Stanislav Rybtsov; Andrejs Ivanovs; Suling Zhao; Alexander Medvinsky One day prior to mass emergence of haematopoietic stem cells (HSCs) in the foetal liver at E12.5, the embryo contains only a few definitive HSCs. It is thought that the burst of HSC activity in the foetal liver is underpinned...

...Anna Liakhovitskaia; Stanislav Rybtsov; Tom Smith; Antoniana Batsivari; Natalia Rybtsova; Christina Rode; Marella de Bruijn; Frank Buchholz; Sabrina Gordon-Keylock; Suling Zhao; Alexander Medvinsky Haematopoiesis in adult animals is maintained by haematopoietic stem cells (HSCs), which self-renew...

...Laurence Petit-Cocault; Cécile Volle-Challier; Maud Fleury; Bruno Péault; Michèle Souyri Cytokine signaling pathways are important in promoting hematopoietic stem cell (HSC) self-renewal, proliferation and differentiation. Mpl receptor and its ligand, TPO, have been shown to play an essential...