... ( Nemec et al., 2017 ; Sheth et al., 2016 ). Hoxa/d13 peaks were isolated from common Hoxa13 and Hoxd13 (maximum summit distance 50 bp) peaks. Genome-wide correlations, heat maps and fill plots were created using EASeq ( Lerdrup et al., 2016 ). Motif searches were performed in 200 bp windows surrounding...

... ensures that patterning events occur only once by grafting GFP-expressing autopod progenitor cells to the earlier host signalling environment of zeugopod progenitor cells. We show by detecting Hoxa13 expression that early and late autopod progenitors fated for the wrist and phalanges, respectively, both...

...Wendy M. Knosp; Virginia Scott; Hans Peter Bächinger; H. Scott Stadler In humans and mice, loss of HOXA13 function causes defects in the growth and patterning of the digits and interdigital tissues. Analysis of Hoxa13 expression reveals a pattern of localization overlapping with sites of reduced...

...Emily A. Morgan; Susan B. Nguyen; Virginia Scott; H. Scott Stadler In humans and mice, mutations in Hoxa13 cause malformation of limb and genitourinary (GU) regions. In males, one of the most common GU malformations associated with loss of Hoxa13 function is hypospadia,a condition defined...

...Pascal de Santa Barbara; Drucilla J. Roberts Hoxa13 is expressed early in the caudal mesoderm and endoderm of the developing hindgut. The tissue-specific roles of Hoxa13 function have not been described. Hand-foot-genital syndrome, a rare dominantly inherited human malformation syndrome...

...Yuanxiang Zhao; S. Steven Potter To better define Abd-B type homeodomain function, to test models that predict functional equivalence of all Hox genes and to initiate a search for the downstream targets of Hoxa13 , we have performed a homeobox swap by replacing the homeobox of the Hoxa11 gene...

... on the expression patterns of two 5′ members of this complex, HoxA13 and HoxA9 . These genes are expressed in cells of developing limb buds and regenerating blastemas. The pattern of expression in developing axolotl limb buds is comparable to that in mouse and chick limb buds; the expression domain of HoxA13...